Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

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Type I Photosensitizer Targeting Glycans: Overcoming Biofilm Resistance by Inhibiting the Two‐Component System, Quorum Sensing, and Multidrug Efflux

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(52)

Published: Nov. 17, 2023

Stubborn biofilm infections pose serious threats to human health due the persistence, recurrence, and dramatically magnified antibiotic resistance. Photodynamic therapy has emerged as a promising approach combat biofilm. Nevertheless, how inhibit bacterial signal transduction system efflux pump conquer recurrence resistance remains challenging unaddressed issue. Herein, boric acid-functionalized lipophilic cationic type I photosensitizer, ACR-DMP, is developed, which efficiently generates •OH overcome hypoxic microenvironment photodynamically eradicates methicillin-resistant Staphylococcus aureus (MRSA) biofilms. Furthermore, it not only alters membrane potential homeostasis osmotic pressure balance its strong binding ability with plasma but also inhibits quorum sensing two-component system, reduces virulence factors, regulates activity of drug attributed glycan-targeting ability, helping prevent In vivo, ACR-DMP successfully obliterates MRSA biofilms attached implanted medical catheters, alleviates inflammation, promotes vascularization, thereby combating accelerating wound healing. This work provides an efficient strategy stubborn multidrug offers systematic guidance for rational design next-generation advanced antimicrobial materials.

Language: Английский

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Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.

Language: Английский

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Advancing Aggregation‐Induced Emission‐Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

ABSTRACT Contagious diseases caused by different types of highly contagious pathogens, such as SARS‐CoV‐2, monkeypox virus, Mycobacterium tuberculosis , and human immunodeficiency could trigger global outbreaks bring a huge public health burden. Advanced diagnostic, therapeutic, preventive strategies are urgently needed to deal with the epidemic diseases. Aggregation‐induced emission (AIE) has emerged one promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, distinguishing aggregation‐enhanced fluorescence. As result, they offer effective for diagnosis, treatment, prevention This review systematically outlined latest research progress AIE‐based biomaterials mechanisms in The versatility AIE molecules, well efficient fluorescence potential innovative combat these challenges. Thanks recent advances materials science better understanding aggregation‐induced luminogens (AIEgens), AIEgens have great provide solutions detection, By reviewing state‐of‐the‐art methods killing, agents highlighting technological developments, this outlook aims promote development new means control emerging, re‐emerging, major further activities critical area research.

Language: Английский

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A mitochondria‐targeted aggregation‐induced emission photosensitizer for eradication Candida biofilms and treating oral ulcer

Smart Molecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract With increasing drug resistance, Candida infections have posed serious threats to public health. Photodynamic therapy harnesses light destroy pathomycete, providing a smart strategy for combating of infections. However, due lack organelle targeting ability and bad extracellular polymeric substances penetrability, current photosensitizers (PSs) are far from desirable clean biofilms fight against resistance. Herein, mitochondrion aggregation‐induced emission PS, LIQ‐TPA‐TZ, was developed the efficient photodynamic treatment oral infection. LIQ‐TPA‐TZ has good singlet oxygen hydroxyl radical generation ability, which can efficiently kill guilliermondii ( C. ) eradicate biofilm. It not only causes mitochondrial damage by disruption respiratory chain oxidative stress‐related gene but also inhibits fungal adhesion filamentous growth prevent colonization, mycelia biofilm formation, is favorable eliminating potential In mouse oropharyngeal infection model, significantly eliminates infection, alleviates inflammation, accelerates mucosal defect healing. This study provides confronting may be Candidate

Language: Английский

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Fungal detection and elimination based on AIEgens

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216548 - 216548

Published: Feb. 26, 2025

Language: Английский

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A Membrane‐Targeted Photosensitizer Prevents Drug Resistance and Induces Immune Response in Treating Candidiasis

Advanced Science, Journal Year: 2023, Volume and Issue: 10(35)

Published: Oct. 24, 2023

Abstract Candida albicans ( C. ), a ubiquitous polymorphic fungus in humans, causes different types of candidiasis, including oral candidiasis (OC) and vulvovaginal (VVC), which are physically mentally concerning financially costly. Thus, developing alternative antifungals that prevent drug resistance induce immunity to eliminate biofilms is crucial. Herein, novel membrane‐targeted aggregation‐induced emission (AIE) photosensitizer (PS), TBTCP‐QY, developed for highly efficient photodynamic therapy (PDT) candidiasis. TBTCP‐QY has high molar absorption coefficient an excellent ability generate 1 O 2 •OH, entering the interior due its permeability. Furthermore, can efficiently inhibit biofilm formation by suppressing expression genes related adhesion ALS3 , EAP1 HWP1 invasion SAP1 SAP2 MDR1 ) also advantageous eliminating potential fungal treat clinical infectious diseases. TBTCP‐QY‐mediated PDT targets OC VVC vivo mouse model, induces immune response, relieves inflammation, accelerates healing mucosal defects combat infections caused clinically isolated fluconazole‐resistant strains. Moreover, demonstrates biocompatibility, suggesting applications treatment VVC.

Language: Английский

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AIE‐Active Antibacterial Photosensitizer Disrupting Bacterial Structure: Multicenter Validation against Drug‐Resistant Pathogens

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Antimicrobial resistance (AMR) has emerged as a global challenge in treating bacterial infections, creating an urgent need for broad-spectrum antimicrobial agents that can effectively combat multidrug-resistant (MDR) bacteria. Despite advancements novel agents, many fail to comprehensively cover common resistant strains or undergo rigorous multi-center validation. Herein, cationic AIE-active photosensitizers are developed, ITPM, derived from triphenylamine-pyridine backbone address the MDR challenge. Rigorous validation demonstrates ITPM possesses superior fluorescence imaging capabilities and exceptional antibacterial efficacy. And its activity is verified through study involving six clinically relevant strains. Additionally, development studies comparisons with advanced clinical antibiotics reveal exhibits potent, minimal development. This efficacy attributed unique mechanism disrupting internal structures. These findings establish promising candidate therapy, offering potential solution growing crisis of AMR settings.

Language: Английский

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Near-infrared organic photosensitizers with aggregation-induced emission and switchable fluorescence for fungal infection therapy

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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Advancements in photodynamic inactivation: A comprehensive review of photosensitizers, mechanisms, and applications in food area

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 3, 2025

Food microbial contamination results in serious food safety issues and numerous loss waste, presenting one of the most significant challenges facing global system. Photodynamic inactivation (PDI) technology, which combines light photosensitizers (PS) to provide antimicrobial effects, is an ideal nonthermal technique for industry. This review provides a comprehensive overview PDI beginning with fundamental photoactivation principles PS pathways photoinduced reactive oxygen species (ROS) generation. critical factor affecting efficiency, categorized into three types: organic, metal oxide-, carbon-based. systemically summarizes photophysical properties, vitro performances, potential enhancement strategies, advantages limitations each type PS. Furthermore, mechanisms technologies are analyzed at both microscopic molecular levels. Finally, current applications various systems discussed, along associated opportunities. Overall, this offers crucial insights optimizing advancing highlighting key suggesting future research directions enhance effectiveness scalability diverse applications.

Language: Английский

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