Strategy to Efficient Photodynamic Therapy for Antibacterium: Donor‐Acceptor Structure in Hydrogen‐Bonded Organic Framework

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 24, 2024

While the construction of a donor-acceptor (D-A) structure has gained great attention across various scientific disciplines, such structures are seldomly reported within field hydrogen-bonded organic frameworks (HOFs). Herein, D-A based HOF is synthesized, where adjacent pairs connected by hydrogen bonds instead conventionally employed covalent bonds. This structural feature imparts material with reduced energy gap between excited state and triplet state, thereby facilitating intersystem crossing (ISC) boosting generation rate single oxygen (quantum yield = 0.98). Consequently, resulting shows high performance for antimicrobial photodynamic therapy (PDT). The impact moiety evident when comparing this finding to parallel study conducted on an isoreticular without structure. presented here provides in-depth insights into photophysical properties pair in network, opening new avenue design innovative materials efficient PDT.

Language: Английский

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Optimizing corrosion resistance of the Mg-4Zn-0.5Y-0.5Nd alloy by regulation of secondary phase and grain structure

Journal of Materials Research and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Reinforcing the photocatalytic removal of ibuprofen antibiotic over S-scheme 2D/1D Bi12O17Cl2/V2O5 heterojunction under solar light illumination

Solar Energy, Journal Year: 2024, Volume and Issue: 277, P. 112751 - 112751

Published: July 1, 2024

Language: Английский

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Cu₂O Nanocubes Embedded in Polycaprolactone Nanofibers for Photo–chemotherapeutic Wound Disinfection and Regeneration

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(15), P. 17707 - 17718

Published: July 25, 2024

Wound-associated infections represent an arduous global healthcare challenge, especially in the "post-antibiotic" era, necessitating development of advanced antimicrobial dressing materials that simultaneously dictate use rapid yet effective disinfection, low drug resistance and side effects, potency to foster tissue healing. Nanoantimicrobial-armored nanostructured functional systems have piqued extensive interest satisfy these criteria. Herein, fusing electrospinning nanotechnology emerging photo–chemo synergistic sterilization paradigm, a smart "all-in-one" multifunctional wound-managing platform was constructed, through incorporating photochemically active nanocrystalline cuprous oxide (Cu2O) into modified polycaprolactone (mPCL) electrospun fibrous mats. The resulting were systematically characterized pertaining physiochemical analysis, photoabsorption photocurrent measurements, photocatalytic reactive oxygen species (ROS) generation. capability this nanoplatform elicit rapid, photoactivated, catalytically augmented bacterial disinfection corroborated, displaying ∼99–100% broad-spectrum antibacterial efficacies against Staphylococcus aureus Escherichia coli 25 min. Benefiting from release Cu2+, mPCL-Cu2O impairs contamination even under dark conditions. Furthermore, also exhibited favorable vitro/-ovo biocompatibility toward NIH3T3 fibroblasts, red blood cells, chick chorioallantoic membrane, alongside appreciable pro-healing capacity bridging scratch-based wounds, which could be attributed nanofiber-afforded biomimetic topography controllable liberation micronutrient Cu ions. This study provides insights design fabrication simple nanoplatforms for biomedical applications.

Language: Английский

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Macro/Microgel‐Encapsulated, Biofilm‐Armored Living Probiotic Platform for Regenerating Bacteria‐Infected Diabetic Wounds

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Infectious diabetic wounds pose an arduous threat to contemporary healthcare. The combination of refractory biofilms, persistent inflammation, and retarded angiogenesis can procure non‐unions life‐threatening complications, calling for advanced therapeutics potent orchestrate anti‐infective effectiveness, benign biocompatibility, pro‐reparative immunomodulation, angiogenic regeneration. Herein, embracing the emergent “living bacterial therapy” paradigm, a designer probiotic‐in‐hydrogel wound dressing platform is demonstrated. constructed employing “macrogel/microgel/biofilm” hierarchical encapsulation strategy, with Lactobacillus casei as model probiotic. Alginate gels, in both macro micro forms, along self‐produced probiotic served encapsulating agents. Specifically, live probiotics are enclosed within alginate microspheres, embedded into bulk matrix, cultivated facilitate biofilm self‐encasing. This multiscale confinement protected averted their inadvertent escape, while enabling sustained secretion, proper reservation, localized delivery therapeutically active metabolites, such lactic acid. resulting biosystem, validated vitro/ovo/vivo, elicited well‐balanced antibacterial activities biological compatibility, alongside prominent pro‐healing, vasculogenic anti‐inflammatory potencies, thus accelerating regeneration infected full‐thickness excisional mice. Such multiple encapsulation‐engineered “all‐in‐one” tactic may shed new light on safe efficient adoption bacteria treating chronic infectious diseases.

Language: Английский

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Dopant‐Regulated Piezocatalysts Evoke Sonopiezoelectric and Enzymatic PANoptosis for Synergistic Cancer Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Piezocatalyst-enabled sonopiezoelectric therapy offers noninvasive treatment with high spatiotemporal selectivity, yet existing piezocatalysts are limited by suboptimal efficacy, cancer cell resistance to oxidative stress, and biosafety concerns. Here, hafnia (HfO2), one of the only few FDA-approved inorganic nanomaterials for clinical trials, is identified as a promising piezocatalyst translational potential enzymatic PANoptosis-boosted nanocatalytic therapy. Specifically, engineered transition metal-substituted HfO2 nanocatalysts synthesized optimize piezoelectric enzyme-mimicking activities. Among these, Mn-substituted 20% Mn ratio (HMO) demonstrates superior performance in sono-triggered reactive oxygen species generation, attributed its reduced bandgap increased vacancies. HMO also exhibits multiple activities, including peroxidase (POD), catalase (CAT), glutathione (GPx), amplifying stress through tumor-specific catalytic reactions. These dual effects enable activation PANoptosis elicit robust antitumor immune response. Biological evaluations show significant tumor suppression responses HMO-mediated Unlike utilizing radiosensitization ability clinic, this work unveils distinctive effect multienzymatic activities HfO2-based biomedical applications, holding overcome challenges radiation damage associated radiotherapy.

Language: Английский

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Influence of Cu2O doped into calcium aluminate: structural, biocompatibility and antibacterial assessment

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Recent advances in carbon nanomaterials: Removal, photodegradation and electrochemical detection of tetracycline, a review

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: 174, P. 113897 - 113897

Published: Jan. 5, 2025

Language: Английский

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A Comparative Study on Centella Asiatica‐Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Implications for Wound Healing

Particle & Particle Systems Characterization, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Conventional wound dressings often lack efficient antimicrobial properties and may exhibit limited bio‐compatibility, necessitating the development of advanced solutions for effective healing. Green synthesis nanoparticles opens door to a strategy that is in terms pharmaceutical biotechnology, besides being nontoxic eco‐friendly. In present study, Centella asiatica leaf extract conjugated with silver copper oxide are synthesized their bioactivity compared. Gas chromatography mass spectrometry (GC‐MS) results show 4‐butoxy‐1‐Butanol, Phthalic acid, 2‐propyldecan‐1‐ol as major phytochemicals . The green‐synthesized (Ag‐NPs) (CuO‐NPs) characterized using transmission electron microscopy (TEM), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). TEM confirm circular morphology Ag‐NPs elliptical structures CuO‐NPs, whereas energy dispersive x‐ray (EDX) spectrum confirms presence Cu Ag respective samples. XRD both high crystallinity. Both demonstrate satisfactory radical scavenging activity confirmed by 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) assay. CuO‐NPs greater antibacterial against Escherichia coli ( E. ) Methicillin‐resistant Staphylococcus aureus MRSA comparison evident from clear zone inhibition obtained. conclusion, green prove have enhanced healing NIH3T3 fibroblast cells than Ag‐NPs.

Language: Английский

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Synthesis of viral-like lignin/Ag nanoparticles with spiky surfaces for antibacterial and antioxidant applications

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141034 - 141034

Published: Feb. 13, 2025

Language: Английский

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