Advances of Metal‐Based Nanomaterials in the Prevention and Treatment of Oral Infections DOI
Junnan Qi,

Chao Si,

Haofeng Liu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

The complicated environment of the oral cavity presents significant challenges to traditional antibacterial approaches, which has driven exploration novel therapeutic strategies. Metal-based nanomaterials (MNMs), with diverse mechanisms (e.g., membrane disruption, oxidative stress) and evolution from empirical theory-guided design, exhibit immense potential. This review introduces pioneering Hierarchical Response Strategy Framework, systematically classifying MNM systems into three progressive levels: Primary category, comprising MNMs that exert spontaneous effects based on inherent physicochemical properties ion release); Secondary including precisely controlled actions by microenvironmental or stimulus-responsive light-induced ROS); Tertiary encompassing integrate regenerative functions for multidimensional therapy remineralization). Through this framework, authors elucidate MNMs' transition single-function precision-controlled, multifunctional synergy, analyze impact metal elements structural design efficacy, summarize their applications in dental caries, endodontic infections, periodontal disease, etc. framework offers a perspective existing research theoretical foundation rational next-generation precise, smart, comprehensive anti-infective materials.

Language: Английский

Interaction Regularity of Biomolecules on Mg and Mg-Based Alloy Surfaces: A First-Principles Study DOI Open Access
Zhe Fang, Baiwei Ma, Erjun Liang

et al.

Coatings, Journal Year: 2023, Volume and Issue: 14(1), P. 25 - 25

Published: Dec. 25, 2023

Adsorbed molecules can modulate the behavior of magnesium (Mg) and Mg alloy in biomedical applications. The interaction regularity mechanism biomolecules (such as amino acids, dipeptides, tripeptide) on a Mg(0001) surface, influence dipole correction, effects alloying elements electronic structure were investigated this study using first-principles calculations. Specifically, adsorption energy (Eads) functional groups (-NH2, -COOH -CN3H4), acids (arginine (Arg), glycine (Gly), aspartic acid (Asp)), dipeptides (arginine–glycine (Arg-Gly), glycine–aspartic (Gly-Asp), arginine–aspartic (Arg-Asp)), arginine–glycine–aspartic (RGD) tripeptide systematically calculated. Dipole correction slightly enhanced between surfaces, but Eads trend remained unchanged. addition improved Mg-based surfaces. This will be fundamental importance understanding surfaces provide possibilities for surface modification design materials.

Language: Английский

Citations

47

Magnesium Hydroxide as a Versatile Nanofiller for 3D-Printed PLA Bone Scaffolds DOI Open Access
Wang Guo,

Wenlang Bu,

Yufeng Mao

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(2), P. 198 - 198

Published: Jan. 9, 2024

Polylactic acid (PLA) has attracted much attention in bone tissue engineering due to its good biocompatibility and processability, but it still faces problems such as a slow degradation rate, acidic product, weak biomineralization ability, poor cell response, which limits wider application developing scaffolds. In this study, Mg(OH)2 nanoparticles were employed versatile nanofiller for PLA/Mg(OH)2 composite scaffolds using fused deposition modeling (FDM) 3D printing technology, mechanical, degradation, biological properties evaluated. The mechanical tests revealed that 5 wt% addition of improved the tensile compressive strengths PLA scaffold by 20.50% 63.97%, respectively. soaking experiment phosphate buffered solution (PBS) alkaline products neutralized PLA, thus accelerating PLA. weight loss rate PLA/20Mg(OH)2 (15.40%) was significantly higher than (0.15%) on day 28. Meanwhile, showed long-term Mg2+ release more 28 days. simulated body fluid (SBF) immersion indicated promoted apatite culture marrow mesenchymal stem cells (BMSCs) adding effectively responses, including adhesion, proliferation, osteogenic differentiation, Mg2+. This study suggests can simultaneously address various issues related polymer scaffolds, properties, interaction, having promising applications engineering.

Language: Английский

Citations

20

Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies DOI Creative Commons
Dan Li, Danni Dai,

Gege Xiong

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 25, 2023

The rapid degradation of magnesium (Mg) alloy implants erodes mechanical performance and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among the solutions to improve corrosion resistance bioefficacy Mg alloys. Novel composite coatings that incorporate nanostructures create new opportunities for expanded use. Particle size dominance impermeability may increase prolong implant service time. Nanoparticles with specific biological effects be released into peri-implant microenvironment during promote healing. Composite nanocoatings provide nanoscale surfaces cell adhesion proliferation. activate cellular signaling pathways, while those porous or core-shell structures carry antibacterial immunomodulatory drugs. vascular reendothelialization osteogenesis, attenuate inflammation, inhibit bacterial growth, thus increasing applicability in complex microenvironments such as atherosclerosis open fractures. This review combines physicochemical properties efficiency Mg-based biomedical summarize advantages nanocoatings, analyzes mechanisms action, proposes design construction strategies, purpose providing a reference promoting application further nanocoatings.

Language: Английский

Citations

43

Smart self-healing coatings on biomedical magnesium alloys: A review DOI Creative Commons
Yanbin Zhao, Jing Bai, Feng Xue

et al.

Smart Materials in Manufacturing, Journal Year: 2023, Volume and Issue: 1, P. 100022 - 100022

Published: Jan. 1, 2023

With promising mechanical property and biodegradability, magnesium (Mg) alloys are considered as the potential candidates in biomedical application. Rapid degradation of Mg compromises performance interfacial bioactivity, hindering clinical adoption. Deposition a surface coating is an effective technique to improve corrosion protection bio-efficacy implants. Because natural degradability corrosion, inevitably damaged complex physiological environment. Therefore, it essential form self-healing that can repair damage restore stable structure functions alloys. This paper reviews recent advances technology related properties including biodegradation behavior, self-repairing activity, biocompatibility, other biological effects, healing mechanism discussed. Self-healing coatings suitable for include conversion coatings, encapsulation multilayered their vitro vivo reviewed by focusing on drug-controlled prolonged release, sterilization, cytocompatibility, osteogenesis, hemocompatibility, angiogenesis. review aims at providing guidance future research development practical

Language: Английский

Citations

25

Efficient dual defense: PDA-Cu coating for simultaneous corrosion resistance and antibacterial protection of Mg alloys DOI
Hao Huang, Lifeng Hou,

Huayun Du

et al.

Corrosion Science, Journal Year: 2024, Volume and Issue: 233, P. 112103 - 112103

Published: May 3, 2024

Language: Английский

Citations

12

Properties and Characteristics of Nanocoatings for Medicinal Applications DOI
John Tsado Mathew, Abel Inobeme, Abdullahi Abdulkadir

et al.

Advances in chemical and materials engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 206 - 230

Published: Feb. 27, 2024

Nanotechnology has emerged as a revolutionary field with diverse applications, including nanocoatings for medicinal purposes. Nanocoatings, their unique properties and capabilities, have opened new avenues drug delivery, medical devices, antimicrobial treatments. Nanocoatings can be engineered to encapsulate therapeutic agents, protecting them from degradation facilitating targeted delivery specific tissues or cells. The use of on surfaces also shown promising results in preventing infections combating antibiotic-resistant pathogens. While offer tremendous potential, concerns about potential toxicity, biocompatibility, long-term effects require rigorous evaluation testing. Furthermore, the study highlights ongoing research future prospects nanocoatings. development multifunctional that combine sensing tissue regeneration holds promise personalized medicine advanced therapeutics.

Language: Английский

Citations

10

A review on the surface topography and corrosion behavior of Mg-alloy coatings for biomedical implants DOI Creative Commons
Praveen Kumar Verma, Sukhpreet Singh,

Monit Kapoor

et al.

Results in Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: 15, P. 100227 - 100227

Published: May 1, 2024

Osteoconductive, biocompatible, and biodegradable magnesium alloys hold great promise as novel materials for orthopaedic vascular implants due to their bone-like mechanical properties. Furthermore, limited utility in therapeutic environments is compounded by inadequate resistance corrosion. Because the impulsive occurrence of corrosion governed loss properties, including materials' fundamental properties various corrosive conditions, mechanism extremely complex. Due incidence numerous factors, inherent presence environments, complexity-ridden.

Language: Английский

Citations

10

Recent development and applications of electrodeposition biocoatings on medical titanium for bone repair DOI

Jialong Yi,

Ming Li, Jixiang Zhu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(39), P. 9863 - 9893

Published: Jan. 1, 2024

Schematic diagram of the device, mechanism and biomedical application electrodeposition for preparation bioactive coatings on surface titanium implants bone repair.

Language: Английский

Citations

10

Piezoelectric materials for bone implants: opportunities and challenges DOI

Xionggang Chen,

Shiping Zhang, Shun Peng

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110841 - 110841

Published: March 1, 2025

Language: Английский

Citations

2

From Layered Perovskites Oxide to Multifunctional Devices: Recent Progress in 2D Niobate Perovskites for Photonics, Catalysis, and Beyond DOI
Ziliang Li, Jigong Hao, Hongbing Wang

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110719 - 110719

Published: Jan. 1, 2025

Language: Английский

Citations

1