TNF-α mediates activation of neuronal necroptotic signaling in rat with syringomyelia

Experimental Neurology, Journal Year: 2025, Volume and Issue: 388, P. 115214 - 115214

Published: March 9, 2025

Language: Английский

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Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Objective Utah arrays are widely used in both humans and non-human primates (NHPs) for intracortical brain-computer interfaces (BCIs), primarily detecting electrical signals from cortical tissue to decode motor commands. Recently, these have also been applied deliver stimulation aimed at restoring sensory functions. A key challenge limiting their longevity is the micromotion between array tissue, which may induce mechanical strain surrounding contribute performance decline. This strain, due mismatch, can exacerbate glial scarring around implant, reducing efficacy of recording neuronal activity delivering stimulation. Approach To investigate this, we employed a finite element model (FEM) predict strains resulting micromotion. Main Results Our findings indicated that profiles edge corner electrodes were greater than those interior shanks, affecting maximum average within 50 µm electrode tip. We then correlated predicted with in-vivo metrics. found negative correlations 1 kHz impedance human NHP area V4 1-mo, 1-yr, 2-yrs post-implantation. In arrays, peak-to-peak waveform voltage (PTPV) signal-to-noise ratio (SNR) spontaneous negatively strain. Conversely, observed positive correlation evoked SNR multi-unit arrays. Significance study establishes spatial dependence correlates

Language: Английский

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Astrocyte regulation of extracellular space parameters across the sleep-wake cycle

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: June 26, 2024

Multiple subfields of neuroscience research are beginning to incorporate astrocytes into current frameworks understanding overall brain physiology, neuronal circuitry, and disease etiology that underlie sleep sleep-related disorders. Astrocytes have emerged as a dynamic regulator activity through control extracellular space (ECS) volume composition, both which can vary dramatically during different levels arousal. also an attractive target due their prominent role in the glymphatic system, method by toxic metabolites generated wakefulness cleared away. In this review we assess literature surrounding glial influences on fluctuations ECS composition across sleep-wake cycle. We examine mechanisms astrocyte regulation solute clearance wake states. Overall, findings highlight importance research.

Language: Английский

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Micromotion Derived Fluid Shear Stress Mediates Peri‐Electrode Gliosis through Mechanosensitive Ion Channels

Advanced Science, Journal Year: 2023, Volume and Issue: 10(27)

Published: July 30, 2023

The development of bioelectronic neural implant technologies has advanced significantly over the past 5 years, particularly in brain-machine interfaces and electronic medicine. However, neuroelectrode-based therapies require invasive neurosurgery can subject tissues to micromotion-induced mechanical shear, leading chronic inflammation, formation a peri-electrode void deposition reactive glial scar tissue. These structures act as physical barriers, hindering electrical signal propagation reducing functionality. Although well documented, mechanisms behind initiation progression these processes are poorly understood. Herein, silico analysis gliosis is described. Subsequently, ventral mesencephalic cells exposed milliscale fluid shear stress vitro exhibited increased expression gliosis-associated proteins overexpression mechanosensitive ion channels PIEZO1 (piezo-type channel component 1) TRPA1 (transient receptor potential ankyrin 1), effects further confirmed vivo rat model gliosis. Furthermore, indicates that chemical inhibition/activation affects mediated astrocyte reactivity mitochondrial-dependent manner. Together, results suggest play major role scarring at region.

Language: Английский

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Brain–Computer Interfaces with Intracortical Implants for Motor and Communication Functions Compensation: Review of Recent Developments

Sovremennye tehnologii v medicine, Journal Year: 2024, Volume and Issue: 16(1), P. 78 - 78

Published: Feb. 28, 2024

Brain-computer interfaces allow the exchange of data between brain and an external device, bypassing muscular system. Clinical studies invasive brain-computer interface technologies have been conducted for over 20 years. During this time, there has a continuous improvement approaches to neuronal signal processing in order improve quality control devices. Currently, with intracortical implants completely paralyzed patients robotic limbs self-service, use computer or tablet, type text, reproduce speech at optimal speed. Studies regularly provide new fundamental on functioning central nervous In recent years, breakthrough discoveries achievements annually made sphere. This review analyzes results clinical experiments implants, provides information stages technology development, its main achievements.

Language: Английский

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Manipulating immune activity of macrophages: a materials and mechanics perspective

Trends in biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

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