Development and Validation of a High-Performance Liquid Chromatography Method to Quantify Marker Compounds in Lysimachia vulgaris var. davurica and Its Effects in Diarrhea-Predominant Irritable Bowel Syndrome DOI Creative Commons
Hye-Youn Kim, Cho-Een Kim, Dool-Ri Oh

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1489 - 1489

Published: March 27, 2024

Irritable bowel syndrome (IBS), a common gastrointestinal disorder worldwide, is characterized by chronic abdominal pain, bloating, and disordered defecation. IBS associated with several factors, including visceral hypersensitivity, gut motility, gut–brain interaction disorders. Because currently available pharmacological treatments cannot adequately improve symptoms may cause adverse effects, the use of herbal therapies for managing increasing. Lysimachia vulgaris var. davurica (LV) medicinal plant used in traditional medicine to treat diarrhea. However, information on whether LV can effectively diarrhea-predominant (IBS-D) remains limited. In this study, using an experimental mouse model IBS-D, we elucidated effects extract. The methanol extract decreased fecal pellet output restraint stress- or 5-hydroxytryptamine (5-HT)-induced inhibited 5-HT-mediated [Ca2+]i increase dose-dependent manner. Furthermore, developed validated high-performance liquid chromatography method two marker compounds, namely, chlorogenic acid rutin, quality control analysis. Our study results suggest feasibility developing therapeutic agents IBS-D acting as 5-HT3 receptor antagonist.

Language: Английский

Chlorogenic acid alleviates the development of severe acute pancreatitis by inhibiting NLPR3 Inflammasome activation via Nrf2/HO-1 signaling DOI Creative Commons
Zhen Ye, Lin Cheng,

Yuanhu Xuan

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114335 - 114335

Published: Feb. 22, 2025

Severe acute pancreatitis (SAP), marked by profound tissue inflammation within the pancreatic tissue, is an abrupt and intense of pancreas. Chlorogenic acid (CGA) one effective pharmacological ingredients components in JinHong Tablet (JHT). The role CGA protecting pancreas from severe injury needs to be studied. intervention with led a significant decline serum amylase lipase levels rats SAP, concurrently mitigating pathological impairment tissue. effectively diminishes pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) SAP inhibiting activation NF-κB NLRP3 inflammasome. Additionally, AR42J cells, application was found reduce inflammatory response induced caerulein. Mechanically, alleviates models activating Nrf2/HO-1 pathway. Together, reduces pathway, thus alleviating development SAP. Our results provide basis for treatment

Language: Английский

Citations

0
Improved effect of antibiotic treatments on the hippocampal spatial memory dysfunction of mice induced by high fluoride exposure: Insight from assembly processes and co-occurrence networks of gut microbial community DOI
Ning Sun,

Jinge Xin,

Zhifang Zhao

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118048 - 118048

Published: March 20, 2025

Language: Английский

Citations

0
The emerging role of honeysuckle flower in inflammatory bowel disease DOI Creative Commons

P. De Muro,

Caihong Jing,

Zhihan Zhao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 28, 2025

Crohn's disease (CD) and ulcerative colitis (UC), referred to as inflammatory bowel (IBD), pose considerable challenges in treatment because they are chronic conditions that easily relapse. The occurrence of IBD continues rise developing countries. Nonetheless, the existing therapies for have limitations fail address needs patients thoroughly. There is an increasing need new, safe, highly effective alternative medications patients. Traditional Chinese Medicine (TCM) employed drug development management due its wide-range biological activities, minimal toxicity, limited side effects. Extensive research has shown certain TCM exhibits significant therapeutic benefits treatments. Honeysuckle (Lonicera japonica) was used clinical settings IBD. Bioactive metabolites L. japonica, such luteolin, quercetin, cyanidin, chlorogenic acid (CGA), caffeic (CA), saponin, exhibit managing honeysuckle flower a potential candidate anti-inflammatory, immune system-regulating, antioxidant qualities. This paper reviews It discusses fundamental mechanism japonica bioactive prevention

Language: Английский

Citations

0
Effect of Artemisia selengensis Turcz extract on lipid metabolism and gut microbiota in high‐fat diet‐induced C57BL/6J obese mice DOI
Lu Zhang,

Mei Deng,

Qing‐Hui Wen

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(4)

Published: April 1, 2025

Abstract Nowadays, obesity is a global health risk factor, and its development closely related to the absorption metabolism of lipids. In this study, main chemical constituents antiobesity effect Artemisia selengensis Turcz extract (ASTE) were investigated by HPLC‐QTOF‐MS 2 obese mice models. Twenty‐three compounds identified from ASTE, caffeoylquinic acid dicaffeoylquinic are dominant bioactive compounds. ASTE administration reduced body weight (9.8%), improved glucose tolerance (14.2%), corrected dyslipidemia (the levels total cholesterol, triglyceride, low‐density lipoprotein cholesterol dropped 19.8%, 24.4%, 27.2%, respectively, high‐density level rose 27.6%), alleviated hepatic lipid accumulation. gut microbiota dysbiosis caused High‐Fat Diet (HFD), mainly increasing relative abundance Odoribacter , Candidatus_Saccharimonas Bacteroides unclassified_f__Lachnospiraceae reducing Faecalibaculum . Gene expression heatmaps pathway enrichment analyses based on transcriptomics indicated that significantly HFD‐induced increases in fatty uptake, triglyceride synthesis, synthesis. Our findings holds significant potential as candidate for modulating preventing or treating obesity, meriting further investigation.

Language: Английский

Citations

0
Chlorogenic acid and intestinal health: mechanistic insights and therapeutic applications DOI
Jinzhao Xu, Xiao Zhao, Shuo Yang

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Chlorogenic acid (CGA), a polyphenolic compound found in various plant species, has shown considerable potential the treatment and management of several diseases due to its potent bioactive properties.

Language: Английский

Citations

0
Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS/STING pathway DOI
Zhichao Jia, Shengjing Liu, Tengfei Chen

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107571 - 107571

Published: June 17, 2024

Language: Английский

Citations

3
Coffee and Alzheimer's disease DOI
Foad Mirzaei,

Lila Agbaria,

Khushbu Bhatnagar

et al.

Progress in brain research, Journal Year: 2024, Volume and Issue: unknown, P. 21 - 55

Published: Jan. 1, 2024

Language: Английский

Citations

2
Traditional Chinese medicine for functional gastrointestinal disorders and inflammatory bowel disease: narrative review of the evidence and potential mechanisms involving the brain-gut axis DOI Creative Commons

RuiXuan Liu,

YunTian Luo,

JinYing Ma

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 17, 2024

Functional gastrointestinal disorders (FGIDs) and inflammatory bowel disease (IBD) are common clinical characterized by recurrent diarrhea abdominal pain. Although their pathogenesis has not been fully clarified, disruptions in intestinal motility immune function widely accepted as contributing factors to both conditions, the brain–gut axis plays a key role these processes. Traditional Chinese Medicine (TCM) employs holistic approach treatment, considers spleen stomach impairments liver abnormality main of two diseases, offers unique therapeutic strategy that targets interconnected pathways. Clinical evidence shows great potential TCM treating FGIDs IBD. This study presents systematic description pathological mechanisms IBD context axis, discusses preclinical studies on acupuncture for treatment summarizes pathways IBD, integrating ancient wisdom with contemporary biomedical insights. The alleviating effects FGID symptoms mainly mediated through modulation immunity inflammation, sensory transmission, neuroendocrine–immune network, microbiota metabolism mechanisms. may be promising option controlling IBD; however, further high-quality research is required. review provides reference an in-depth exploration interventional underscoring TCM’s recalibrate dysregulated

Language: Английский

Citations

2
Chlorogenic acid improves the development of porcine parthenogenetic embryos by regulating oxidative stress and ameliorating mitochondrial function DOI

He‐Xuan Qu,

Yan‐Qiu Wang,

Yan‐Wei Dong

et al.

Reproduction in Domestic Animals, Journal Year: 2024, Volume and Issue: 59(5)

Published: May 1, 2024

Abstract Chlorogenic acid (CGA) is an effective phenolic antioxidant that can scavenge hydroxyl radicals and superoxide anions. Herein, the protective effects mechanisms leading to CGA‐induced porcine parthenogenetic activation (PA) in early‐stage embryos were investigated. Our results showed 50 μM CGA treatment during vitro culture (IVC) period significantly increased cleavage blastocyst formation rates improved quality of derived from PAs. Then, genes related zygotic genome (ZGA) identified investigated, revealing promote ZGA PA embryos. Further analysis revealed IVC decreased abundance reactive oxygen species (ROS), glutathione enhanced activity catalase dismutase Mitochondrial function mitochondrial membrane potential ATP levels upregulated homeostasis‐related gene NRF‐1 In summary, our suggest helps by regulating oxidative stress improving function.

Language: Английский

Citations

1
Dihydromyricetin improves growth performance, immunity, and intestinal functions in weaned pigs challenged by enterotoxigenic Escherichia coli DOI Creative Commons

Kunhong Xie,

Jiawen Qi,

Lili Deng

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: July 26, 2024

Enteric infection is a major cause of enteric disorder in neonatal pigs during the weaning transition. Dihydromyricetin (DMY) natural flavanonol compound extracted from Ampelopsis grossedentata with numerous biological activities such as antioxidative and immunomodulatory functions. The objective this study was to investigate effects dietary dihydromyricetin supplementation on growth performance, immunity, intestinal functions weaned challenged by enterotoxigenic Escherichia coli (ETEC). In total, 24 DLY (Duroc × Landrace Yorkshire) were allotted 3 treatments. Pigs fed basal diet or containing 300 mg/kg DMY orally infused sterilized culture ETEC (2.5 10 11 colony-forming units). Dietary significantly elevated final weight average daily gain (ADG) but reduced diarrhea incidence EDMY group compared ECON ( p < 0.05). Compared group, also improved digestibility dry matter (DM), ether extract (EE), gross energy (GE), ash Moreover, not only decreased ratio albumin/globulin serum concentrations immunoglobulins (e.g., IgA IgG) Interestingly, villus height, height crypt depth (V:C), mucosal alkaline phosphatase, sucrase, maltase duodenum jejunum higher than those Importantly, expression levels jejunal zonula occludens-1 (ZO-1), claudin-1, cationic amino acid transporter-1 (CAT-1), fatty transport protein-1 (FATP-1) Additionally, increased microbial SCFA metabolites acetic propanoic acid), abundance cecum can attenuate ETEC–induced retardation injury, which attributed amelioration nutrient digestion well microbiota.

Language: Английский

Citations

1