Ceramics International, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101773 - 101773
Published: April 1, 2025
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 240, P. 113966 - 113966
Published: May 14, 2024
Language: Английский
Citations
3
Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 273 - 291
Published: Sept. 25, 2024
Language: Английский
Citations
3
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(18)
Published: Jan. 18, 2024
Abstract Compared with water‐soluble osteogenic drugs, fat‐soluble drugs exhibit higher bioavailability and drug stability, making them valuable for enhancing the osseointegration of implants. However, existing drug‐loading coatings are primarily designed limiting their effectiveness in loading delivering drugs. This study employed alkali treatment, silanization, oleic acid acylation to sequentially modify surface Ti alloy, aiming fabricate surfaces capable efficiently Results show that hydrophilicity capacity strongly depended on duration treatment. Furthermore, release mechanism involved direct diffusion from coating cells contact, resulting improved bioavailability, as opposed into surrounding medium subsequent cellular uptake. In vitro experiments using vitamine D3 (VD 3 ) a model confirmed effectively promoted bone formation through highly efficient delivery VD . vivo demonstrated ‐loaded lipophilic significantly enhanced capability titanium provides promising strategy onto implants experimental evidence demonstrating significant value promoting implant osseointegration.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 349 - 349
Published: Dec. 26, 2023
In a previous study, we successfully coated hydroxyapatite (HAp) onto titanium (Ti) plates using the erbium-doped yttrium aluminum garnet pulsed-laser deposition (Er:YAG-PLD) method. this performed further experiments to validate in vitro osteogenic properties, macrophage polarization, and vivo osseointegration activity of HAp-coated Ti (HAp-Ti) screws. Briefly, HAp film surfaces screws via Er:YAG-PLD. The surface morphological, elemental, crystallographic analyses confirmed successful coating. polarization induction were evaluated macrophages rat bone marrow mesenchymal stem cells, properties studied. results showed that needle-shaped nano-HAp promoted early expression immunogenic genes induced excellent M2 properties. calcium osteocalcin production significantly higher HAp-Ti than uncoated Ti. implantation into femurs revealed materials had superior osteoinductive activities compared with Ti, as assessed by microcomputed tomography histology. Thus, on sandblasted Er:YAG-PLD enhances hard-tissue differentiation, new formation tissues surrounding implants both vivo.
Language: Английский
Citations
6
Surface and Coatings Technology, Journal Year: 2024, Volume and Issue: 479, P. 130497 - 130497
Published: Jan. 30, 2024
Language: Английский
Citations
1
Advanced Materials Interfaces, Journal Year: 2024, Volume and Issue: 11(24)
Published: May 9, 2024
Abstract Tissue‐engineered extraction products, such as apoptotic extracellular vesicles (ApoEVs), significantly promote tissue regeneration, endowing them with the potential to improve osseointegration. However, there is an urgent need determine how effectively load these materials onto a material surface maximize their function. Considering that all products have phospholipid bilayer, phospholipid‐modified implant coating designed can tissue‐engineered bilayer structure. ApoEVs are loaded and osteogenic effect improved, achieving good In vitro experiments show this improves angiogenesis by promoting macrophage M1 polarization NO secretion in early stages. vivo after implantation, it peri‐implant vascularization of implant, thereby improving new bone formation ability This study provides universal solution for loading vesicular validates its fusion using example while exploring mechanism.
Language: Английский
Citations
1
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(6), P. 3984 - 3993
Published: May 10, 2024
Guided bone regeneration (GBR) membranes that reside at the interface between and soft tissues for repair attract increasing attention, but currently developed GBR suffer from relatively poor osteogenic antibacterial effects as well limited mechanical property biodegradability. We present here design fabrication of a bifunctional Janus membrane based on shear flow-driven layer by self-assembly approach. The comprises calcium phosphate-collagen/polyethylene glycol (CaP@COL/PEG) chitosan/poly(acrylic acid) (CHI/PAA) different sides collagen to form sandwich structure. exhibits good stability tailored It is found CaP@COL/PEG CHI/PAA contribute differentiation function, respectively. In comparison with control group, displays 2.52-time 1.84-time enhancement in respective volume density newly generated bone. greatly improved ability further confirmed through histological analysis, it has great potential practical applications tissue engineering.
Language: Английский
Citations
1
New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(25), P. 11465 - 11475
Published: Jan. 1, 2024
A good biocompatible multifunctional Ti implant was constructed, which exhibits synergistic antibacterial activity through photothermal and NO effects, promotes osseointegration.
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(34), P. 44451 - 44466
Published: Aug. 14, 2024
Bone and tooth defects can considerably affect the quality of life health patients, orthopedic implants remain primary method addressing such defects. However, implant materials cannot coordinate with immune microenvironment because their biological inertness, which may lead to loosening or failure. Motivated by microstructure nacre, we engineered a biomimetic micro/nanoscale topography on tantalum surface using straightforward method. This comprised an organized array nanotubes arranged in brick wall structure, epigallocatechin gallate acting as "mortar." The coating improved corrosion resistance, biocompatibility, antioxidant properties. In vitro vivo evaluations further confirmed that coatings create favorable bone through synergistic effects mechanochemistry enhance integration. research offers new viewpoint creation sophisticated functional implants, possessing vast potential for use regeneration repair tissue.
Language: Английский
Citations
1