Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 31, 2024
Cancer
stem
cells,
characterized
by
high
tumorigenicity
and
drug-resistance,
are
often
responsible
for
tumor
progression
metastasis.
Aldehyde
dehydrogenases,
overexpressed
in
cancer
cells
enriched
tumors,
present
a
potential
target
specific
anti-cancer
treatment.
In
this
study,
we
report
self-assembled
nano-prodrug
composed
of
aldehyde
dehydrogenases
activatable
photosensitizer
disulfide-linked
all-trans
retinoic
acid
diagnosis
targeted
treatment
tumors.
The
can
load
with
self-assemble
into
stable
nano-prodrug,
which
be
disassembled
level
glutathione.
As
the
released
photosensitizer,
dehydrogenase
catalyzes
oxidation
aldehydes
to
carboxyl
under
microenvironment,
activating
generation
reactive
oxygen
species
fluorescence
emission.
This
leads
direct
killing
is
accompanied
noticeable
enhancement
real-time
monitoring
microenvironment.
Moreover,
acid,
as
differentiation
agent,
reduce
stemness
improve
offering
synergistic
effect
enhanced
inhibition
vivo
growth
Luminescence,
Journal Year:
2023,
Volume and Issue:
39(1)
Published: Dec. 3, 2023
Near-infrared
(NIR)
fluorescence
imaging-guided
photodynamic
therapy
(PDT)
technology
plays
an
important
role
in
treating
various
diseases
and
still
attracts
increasing
research
interests
for
developing
novel
photosensitizers
(PSs)
with
outstanding
performances.
Conventional
PSs
such
as
porphyrin
rhodamine
derivatives
have
easy
self-aggregation
properties
the
physiological
environment
due
to
their
inherent
hydrophobic
nature
caused
by
rigid
molecular
structure
that
induces
strong
intermolecular
stacking
π-π
interaction,
leading
serious
quenching
cytotoxic
reactive
oxygen
species
(ROS)
reduction.
Meanwhile,
hypoxia
is
barrier
microenvironment
of
solid
tumors,
seriously
restricting
therapeutic
outcome
conventional
PDT.
Aforementioned
disadvantages
should
be
overcome
urgently
enhance
effect
PSs.
Novel
NIR
fluorescence-guided
type
I
aggregation-induced
emission
(AIE),
which
features
advantages
improving
fluorescent
intensity
ROS
generation
efficiency
at
aggregation
well
tolerance,
bring
hope
resolving
aforementioned
problems
simultaneously.
At
present,
plenty
works
fully
demonstrates
advancement
AIE-active
PDT
based
on
In
this
review,
cutting-edge
advances
focusing
include
aspects
photochemical
mechanism
generation,
structures
reported
design
strategies,
typical
anticancer
applications
are
summarized.
Finally,
a
brief
conclusion
obtained,
underlying
challenges
prospects
proposed.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1699 - 1707
Published: Feb. 1, 2024
Introduction:
The
presence
of
cancer
stem
cells
(CSCs)
significantly
limits
the
therapeutic
efficacy
radiotherapy
(RT).
Efficient
elimination
potential
CSCs
is
crucial
for
enhancing
effectiveness
RT.
Methods:
In
this
study,
we
developed
a
biomimetic
hybrid
nano-system
(PMC)
composed
MnCO
3
as
inner
core
and
platelet
membrane
(PM)
outer
shell.
By
exploiting
specific
recognition
properties
surface
proteins,
PMC
enables
precise
targeting
CSCs.
Sonodynamic
therapy
(SDT)
was
employed
using
manganese
carbonate
nanoparticles
(MnCO
NPs),
which
generate
abundant
reactive
oxygen
species
(ROS)
upon
ultrasound
(US)
irradiation,
thereby
impairing
CSC
self-renewal
capacity
eradicating
Subsequent
RT
effectively
eliminates
common
tumor
cells.
Results:
Both
in
vitro
cell
experiments
vivo
animal
studies
demonstrate
that
SDT
mediated
by
synergistically
enhances
to
selectively
combat
while
inhibiting
growth
without
noticeable
side
effects.
Discussion:
Our
findings
offer
novel
insights
safety
profiles
Keywords:
clearance,
radiosensitization,
membrane,
sonodynamic
therapy,
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101119 - 101119
Published: June 11, 2024
Cancer
represents
a
significant
threat
to
human
health,
with
the
use
of
traditional
chemotherapy
drugs
being
limited
by
their
harsh
side
effects.
Tumor-targeted
nanocarriers
have
emerged
as
promising
solution
this
problem,
they
can
deliver
directly
tumor
site,
improving
drug
effectiveness
and
reducing
adverse
However,
efficacy
most
nanomedicines
is
hindered
poor
penetration
into
solid
tumors.
Nanomotors,
capable
converting
various
forms
energy
mechanical
for
self-propelled
movement,
offer
potential
enhancing
delivery
deep
regions.
External
force-driven
nanomotors,
such
those
powered
magnetic
fields
or
ultrasound,
provide
precise
control
but
often
necessitate
bulky
costly
external
equipment.
Bio-driven
propelled
sperm,
macrophages,
bacteria,
utilize
biological
molecules
self-propulsion
are
well-suited
physiological
environment.
constrained
lifespan,
inadequate
speed,
immune
responses.
To
address
these
issues,
nanomotors
been
engineered
propel
themselves
forward
catalyzing
intrinsic
"fuel"
in
microenvironment.
This
mechanism
facilitates
through
barriers,
allowing
them
reach
regions
targeted
delivery.
In
regard,
article
provides
review
microenvironment-activatable
(fueled
hydrogen
peroxide,
urea,
arginine),
discusses
prospects
challenges
clinical
translation,
aiming
new
insights
safe,
efficient,
treatment
cancer
therapy.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 31, 2024
Cancer
stem
cells,
characterized
by
high
tumorigenicity
and
drug-resistance,
are
often
responsible
for
tumor
progression
metastasis.
Aldehyde
dehydrogenases,
overexpressed
in
cancer
cells
enriched
tumors,
present
a
potential
target
specific
anti-cancer
treatment.
In
this
study,
we
report
self-assembled
nano-prodrug
composed
of
aldehyde
dehydrogenases
activatable
photosensitizer
disulfide-linked
all-trans
retinoic
acid
diagnosis
targeted
treatment
tumors.
The
can
load
with
self-assemble
into
stable
nano-prodrug,
which
be
disassembled
level
glutathione.
As
the
released
photosensitizer,
dehydrogenase
catalyzes
oxidation
aldehydes
to
carboxyl
under
microenvironment,
activating
generation
reactive
oxygen
species
fluorescence
emission.
This
leads
direct
killing
is
accompanied
noticeable
enhancement
real-time
monitoring
microenvironment.
Moreover,
acid,
as
differentiation
agent,
reduce
stemness
improve
offering
synergistic
effect
enhanced
inhibition
vivo
growth
