Nanotherapeutics to cure inflammation-induced cancer DOI Open Access
Rajiv Kumar

Current Cancer Reports, Journal Year: 2024, Volume and Issue: 6(1), P. 193 - 204

Published: July 2, 2024

Aims: Nanotherapeutics are being explored as a potential solution to treat inflammation-induced cancer. enhance innate immune cells' immunity, enabling them fight tumors effectively. These cells secrete specific chemicals like cytokines, allowing replicate quickly and respond future threats, making suitable for immunotherapy.Methods: Nanotechnology can significantly improve human health by enhancing infection detection, prevention, treatment. Nanomedicines, composed of restorative imaging compounds in submicrometer-sized materials, aim deliver effective treatments limit inflammation healthy body areas. Combining nanotechnology clinical sciences, nanoparticles gene therapy have been developed treating various diseases, including cancer, cardiovascular, diabetes, pulmonary, inflammatory diseases.Results: Neutrophils their offspring, films extracellular vehicles, crucial drug transporters enhanced growth therapy. Tumor microenvironment inputs modify tumor-associated neutrophils (TANs), which essential tumor healing. Human intratumor heterogeneity is Nanomedicines shown targeted delivery, toxicity reduction, therapeutic effectiveness enhancement. However, relevance efficacy remain inadequate due lack understanding the interaction between nanomaterials, nanomedicine, biology. The diverse biological milieu impacts dynamic bioidentity nanoformulations, interactions function or cellular absorption.Conclusion: holds great promise improving detecting, preventing, infections. fusion sciences nanotechnology, use transporter materials delivery reducing contamination. Nanoparticles' small size high surface-to-volume ratio benefit Research has led wide range nanomedicine products globally.

Language: Английский

3D Multispheroid Assembly Strategies towards Tissue Engineering and Disease Modeling DOI

Tong Zhu,

Yan Hu, Haitao Cui

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Cell spheroids (esp. organoids) as 3D culture platforms are popular models for representing cell–cell and cell–extracellular matrix (ECM) interactions, bridging the gap between 2D cell cultures natural tissues. with spatially organized multiple types preferred gaining comprehensive insights into tissue pathophysiology constructing in vitro tissues disease because of complexities In recent years, an assembly strategy using (or living building blocks has been developed to construct complex spatial organization. Here, a overview advances multispheroid studies is provided. The different mechanisms techniques, i.e., automated directed assembly, noncontact remote programmed self‐assembly, introduced. processing steps, advantages, technical limitations existing methodologies summarized. Applications strategies modeling, drug screening, engineering, organogenesis reviewed. Finally, this review concludes by emphasizing persistent issues future perspectives, encouraging researchers adopt techniques generating advanced that better resemble real

Language: Английский

Citations

8
Detachable DNA Assembly Module to Dissect Tumor Cells Heterogeneity via RNA Pinpoint Screening DOI Creative Commons
Wei Liu,

Ni Liao,

Yan‐Mei Lei

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Differential RNA expression is becoming increasingly valuable in evaluating tumor heterogeneity for a better understanding of malignant tumors and guiding personalized therapy. However, traditional techniques analyzing cellular are mainly focused on determining the absolute level RNA, which may lead to inaccuracies heterogeneity, primarily due i) subtle differences certain types that have similar total concentrations ii) existence variations across different samples. Herein, detachable DNA assembly module proposed capable not only quantifying target but also innovatively its proportion within family population through sequential disassembly route. Using let‐7 as an experimental model, significant difference discovered let‐7a between normal mammary epithelial cells breast cancer cells, characteristic often missed bulk analysis techniques. By combining concentration information, demonstrates markedly higher efficiency discerning among various compared This innovative expected offer new perspective highlight guide

Language: Английский

Citations

8
Developing 3D bioprinting for organs-on-chips DOI
Zhuhao Wu, Rui Liu, Ning Shao

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Organs-on-chips (OoCs) can be directly fabricated by 3D bioprinting techniques, which enhance the structural and functional fidelity of organ models broaden applications OoCs.

Language: Английский

Citations

0
An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models DOI

Pratibha Parihar,

Naina Sunildutt,

Chethikkattuveli Salih Abdul Rahim

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(6)

Published: Feb. 22, 2024

Abstract Vascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer faithful representation of cancer vitro, exploration biology, evaluation drug efficacy, and anticipation patient responses therapies. Compared conventional ones, VToC systems hold advantages by creating milieu where physiological conditions for investigating tumor–host interactions pivotal advancement/therapy resilience. Nevertheless, models confront limitations encompassing vascular network replication, biological fidelity, mechanical/chemical integrity, intricacies architectural design. Thus, drawbacks inherent prevailing models’ intricacies, attributes, establishment imperative. This systematic review focuses the recent advancements, technologies explored incorporating models, vascularization approaches investigation, factors/parameters affecting complex microenvironments along with futuristic approach design strategies, fabrication techniques, understanding network, also spheroid. A comprehensive analysis based their practical highlights promising strategies possible applications. will be essential regarding complete overview future direction toward developing efficient compared state‐of‐the‐art VToC.

Language: Английский

Citations

3
Engineering Heterogeneous Tumor Models for Biomedical Applications DOI Creative Commons
Zhuhao Wu, Danqing Huang, Jinglin Wang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 9, 2023

Abstract Tumor tissue engineering holds great promise for replicating the physiological and behavioral characteristics of tumors in vitro. Advances this field have led to new opportunities studying tumor microenvironment exploring potential anti‐cancer therapeutics. However, main obstacle widespread adoption models is poor understanding insufficient reconstruction heterogeneity. In review, current progress heterogeneous discussed. First, major components heterogeneity are summarized, which encompasses various signaling pathways, cell proliferations, spatial configurations. Then, contemporary approaches elucidated that guided by fundamental principles biology, a bottom‐up approach highlighted. Additionally, characterization biomedical applications discussed, emphasizing significant role engineered scientific research clinical trials. Lastly, challenges promoting oncology therapy described key directions future provided.

Language: Английский

Citations

7
The use of microphysiological systems to model metastatic cancer DOI Creative Commons
Caitlin E. Jackson, Nicola Green, William English

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 16(3), P. 032002 - 032002

Published: April 5, 2024

Abstract Cancer is one of the leading causes death in 21st century, with metastasis cancer attributing to 90% cancer-related deaths. Therefore, improve patient outcomes there a need for better preclinical models increase success translating oncological therapies into clinic. Current traditional static vitro lack perfusable network which critical overcome diffusional mass transfer limit provide mechanism exchange essential nutrients and waste removal, their physiological relevance. Furthermore, these typically cellular heterogeneity key components immune system tumour microenvironment. This review explores rapidly developing strategies utilising microphysiological systems (MPS) investigating cell metastasis. In this we initially outline mechanisms metastasis, highlighting steps identifying current gaps our understanding metastatic cascade, exploring MPS focused on individual cascade before detailing latest can investigate multiple cascade. then focuses factors affect performance an designed applications final discussion summarising challenges future directions use models.

Language: Английский

Citations

1
Nanotherapeutics to cure inflammation-induced cancer DOI Open Access
Rajiv Kumar

Current Cancer Reports, Journal Year: 2024, Volume and Issue: 6(1), P. 193 - 204

Published: July 2, 2024

Aims: Nanotherapeutics are being explored as a potential solution to treat inflammation-induced cancer. enhance innate immune cells' immunity, enabling them fight tumors effectively. These cells secrete specific chemicals like cytokines, allowing replicate quickly and respond future threats, making suitable for immunotherapy.Methods: Nanotechnology can significantly improve human health by enhancing infection detection, prevention, treatment. Nanomedicines, composed of restorative imaging compounds in submicrometer-sized materials, aim deliver effective treatments limit inflammation healthy body areas. Combining nanotechnology clinical sciences, nanoparticles gene therapy have been developed treating various diseases, including cancer, cardiovascular, diabetes, pulmonary, inflammatory diseases.Results: Neutrophils their offspring, films extracellular vehicles, crucial drug transporters enhanced growth therapy. Tumor microenvironment inputs modify tumor-associated neutrophils (TANs), which essential tumor healing. Human intratumor heterogeneity is Nanomedicines shown targeted delivery, toxicity reduction, therapeutic effectiveness enhancement. However, relevance efficacy remain inadequate due lack understanding the interaction between nanomaterials, nanomedicine, biology. The diverse biological milieu impacts dynamic bioidentity nanoformulations, interactions function or cellular absorption.Conclusion: holds great promise improving detecting, preventing, infections. fusion sciences nanotechnology, use transporter materials delivery reducing contamination. Nanoparticles' small size high surface-to-volume ratio benefit Research has led wide range nanomedicine products globally.

Language: Английский

Citations

0