ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine DOI

Zhengyang Quan,

Sa Wang,

Huanhuan Xie

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.

Language: Английский

Nanomedicine for Diagnosis and Treatment of Atherosclerosis DOI Creative Commons
Jingyun Cheng, Hui Huang, Yu Chen

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)

Published: Oct. 28, 2023

Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.

Language: Английский

Citations

40
Curcumin and nanodelivery systems: New directions for targeted therapy and diagnosis of breast cancer DOI Open Access
Ruhong Zhou,

Jie Gong,

Xianguang Deng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117404 - 117404

Published: Sept. 21, 2024

Language: Английский

Citations

14
Ultrasound Tissue Engineering Technology for Regulating Immune Microenvironment DOI

Xinhe Li,

Xiaoqian Ding,

Yi He

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: March 3, 2024

Abstract The immune microenvironment is critical for the occurrence, progression, and treatment of diseases. Ultrasound tissue engineering technology utilizes ultrasound principles to repair, regenerate, functionally reconstruct biological tissues. therapy a non‐invasive modality that regulates maintains homeostasis through various characteristic effects. Ultrasound‐responsive biomaterials utilize properties or drug/gene delivery regulate under stimulation targeted purposeful treatment. This article comprehensively systematically reviews advancements in regulating microenvironment. First, changes at different stages disease briefly illustrated. It then reviewed regulation by ultrasound‐responsive five types diseases: tumor, cardiovascular system diseases, nervous musculoskeletal wound. Finally, prospects summarized.

Language: Английский

Citations

7
Equisetin protects from atherosclerosis in vivo by binding to STAT3 and inhibiting its activity DOI Creative Commons
Yuting Yang, Jingzhu Wang, Yang Tian

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107289 - 107289

Published: July 1, 2024

Atherosclerosis is a chronic inflammatory vascular disease characterized by lipid metabolism disorder and accumulation. Equisetin (EQST) hemiterpene compound isolated from fungus of marine sponge origin, which has antibacterial, anti-inflammatory, lipid-lowering, weight loss effects. Whether EQST anti-atherosclerotic activity not been reported. In this study, we revealed that displayed anti- atherosclerosis effects through inhibiting macrophage response, uptake foam cell formation in vitro, finally ameliorated high-fat diet (HFD)-induced AopE

Language: Английский

Citations

6
Multipathway Regulation for Targeted Atherosclerosis Therapy Using Anti-miR-33-Loaded DNA Origami DOI
Yuxuan Ma, Qi Wang,

Shiyu Du

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 6, 2024

Given the multifactorial pathogenesis of atherosclerosis (AS), a chronic inflammatory disease, combination therapy arises as compelling approach to effectively address complex interplay pathogenic mechanisms for more desired treatment outcome. Here, we present

Language: Английский

Citations

5
Biomarkers That Seem to Have the Greatest Impact on Promoting the Formation of Atherosclerotic Plaque in Current Scientific Research DOI Creative Commons

Maksymilian Kłosowicz,

Dawid Leksa,

Dorota Bartusik‐Aebisher

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 9503 - 9522

Published: Aug. 29, 2024

Atherosclerosis is a chronic inflammatory disease that causes degenerative and productive changes in the arteries. The resulting atherosclerotic plaques restrict vessel lumen, causing blood flow disturbances. Plaques are formed mainly large- medium-sized arteries, usually at bends forks where there turbulence flow. Depending on their location, they can lead to various states such as myocardial infarction, stroke, renal failure, peripheral vascular diseases, or sudden cardiac death. In this work, we reviewed literature early detection of atherosclerosis markers application photodynamic therapy atherosclerosis-related diseases. Herein, described roles C-reactive protein, insulin, osteopontin, osteoprotegerin, copeptin, TGF-β cytokine family, amino acid homocysteine. Also, discuss role microelements iron, copper, zinc, Vitamin D promoting formation plaque. Dysregulation administered compounds associated with an increased risk atherosclerosis. Additionally, taking into account pathophysiology plaque formation, believe maintaining homeostasis range biomarkers mentioned article crucial for slowing down process development stability already formed.

Language: Английский

Citations

5
Endothelium-Targeted NF-κB siRNA Nanogel for Magnetic Resonance Imaging and Visualized-Anti-inflammation Treatment of Atherosclerosis DOI Creative Commons
Yuanyuan Guo, Fujun Wang,

Sunli Wan

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122897 - 122897

Published: Oct. 17, 2024

Language: Английский

Citations

4
Advanced Applications of Nanomaterials in Atherosclerosis Diagnosis and Treatment: Challenges and Future Prospects DOI

Junran Tong,

Zhiwen Wang, Jiahui Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58072 - 58099

Published: Oct. 21, 2024

Atherosclerosis-induced coronary artery disease is a major cause of cardiovascular mortality. Clinically, conservative treatment strategies for atherosclerosis still focus on lifestyle interventions and the use lipid-lowering anticoagulant medications. Despite achieving some therapeutic effects, these approaches are limited by low bioavailability, long intervention periods, significant side effects. With advancement nanotechnology, nanomaterials have demonstrated extraordinary potential in biomedical field. Their excellent biocompatibility, surface modifiability, high targeting capability not only enable efficient diagnosis plaque progression but also allow precise drug delivery within atherosclerotic plaques, significantly enhancing bioavailability reducing systemic Here, we systematically review current research progress field to summarize types their applications both atherosclerosis. Notably, context therapy, provide comprehensive overview nanomaterial based targeted systems different cell plaques. Additionally, address persistent challenge clinical translation summarizing issues providing directions innovation improvement design. Overall, believe that this summarizes challenges thereby offering insights references development materials

Language: Английский

Citations

4
UCST Polymeric H2S‐Donor Fabricated Nanomedicine Managing Atherosclerosis by Gas‐Photothermal Therapy Involving a “Turning Waste into Treasure” Strategy DOI Open Access

Xuechun Ren,

Di Gao, Xinyang Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Atherosclerosis (AS) stands as a primary cause of vascular diseases worldwide, with its occurrence and progression being attributed to the interplay multiple risk factors. Therefore, it is imperative develop comprehensive strategy aimed at effectively mitigating reversing AS. Herein, hydrogen sulfide (H 2 S) donor incorporated into thermal‐sensitive polymer possessing an upper critical solution temperature (UCST), which not only serves novel macromolecular H S but also forms targeted nanocarrier for delivering near infrared II photothermal agent, achieving gas‐photothermal therapy against AS notable advantages. For one aspect, multifunctional UCST nanomedicine could target atherosclerotic plaque perform photoacoustic imaging‐guided S‐photothermal reduce ratio en‐face aortic lesion areas from 17.2% 6.5% alleviate inflammatory microenvironment. another inevitable hepatic accumulation would activate 5'‐adenosine monophosphate (AMP)‐activated protein kinase/mammalian rapamycin signaling pathway, thereby enhancing lipid metabolism reducing plasma triglyceride levels. This transformation waste valuable asset further aids in inhibiting Consequently, here mediate effective attenuate

Language: Английский

Citations

0
The molecular mechanisms of cuproptosis and its relevance to atherosclerosis DOI Creative Commons
Jiankang Wang, Zhian Chen,

Hang Shang

et al.

Biomolecules and Biomedicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Atherosclerosis is a chronic inflammatory disease associated with lipid deposition in the vascular intima. Copper vital trace element implicated onset and progression of atherosclerosis. Excessive intracellular copper accumulation induces unique form cell death termed “cuproptosis.” The emergence concept cuproptosis has highlighted potential role This review explores regulatory mechanisms metabolism cuproptosis, summarizes recent findings on link between excess atherosclerosis, examines how may influence atherosclerosis progression. goal to propose novel diagnostic therapeutic strategies for through lens cuproptosis.

Language: Английский

Citations

0