Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(12), P. 372 - 372
Published: Dec. 9, 2024
CY1-4,
9-nitropyridine
[2',3':4,5]
pyrimido
[1,2-α]
indole
-5,11-
dione,
is
an
indoleamine
2,3-dioxygenase
(IDO)
inhibitor
and
a
poorly
water-soluble
substance.
It
very
important
to
increase
the
solubility
of
CY1-4
improve
its
bioavailability
therapeutic
effect.
In
this
study,
mesoporous
silica
nano-skeleton
carrier
material
Sylysia
was
selected
as
load
then
drug
delivery
system
(MSNM@CY1-4)
prepared
by
coating
hydrophilic
polymer
Hydroxypropyl
methylcellulose
(HPMC)
lipid
Distearoylphosphatidyl-ethanolamine-poly(ethylene
glycol)
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Abstract
There
is
a
desperate
need
for
precise
nanomedications
to
treat
ischemic
cerebral
injury.
Yet,
the
drawbacks
of
poor
delivery
efficiency
and
off‐target
toxicity
in
pathologic
parenchyma
traditional
antioxidants
against
stroke
result
inadequate
brain
accumulation.
M13
bacteriophages
are
highly
phagocytosed
by
M1‐polarized
microglia
can
be
carried
toward
neuroinflammatory
sites.
Here,
bio‐active,
inhalable,
Ce
0.9
Zr
0.1
O
2
‐backpacked‐M13
phage
(abbreviated
as
CZM)
developed
demonstrates
how
taken
up
different
phenotypes’
microglia.
With
M1
microglia's
proliferating
migrating,
CZM
extensively
specifically
delivered
site
core
penumbra,
where
surviving
nerve
cells
shielded
from
secondary
oxidative
stress
inflammatory
cascade
initiated
reactive
oxygen
species
(ROS).
non‐invasive
administration,
effectively
alleviates
damage
apoptosis
neurons
eliminating
ROS
generated
hyperactive
secure
effective
strategy
targeted
therapy
maladies
offered
this
research.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 10, 2024
Cancer
immunotherapy
has
emerged
as
a
pivotal
approach
for
treating
various
types
of
cancer,
incorporating
strategies
such
chimeric
antigen
receptor
T-cell
(CAR-T)
therapy,
immune
checkpoint
blockade
neoantigen
peptides,
mRNA
vaccines,
and
small
molecule
modulators.
However,
the
clinical
efficacy
these
therapies
is
frequently
constrained
by
significant
adverse
effects
limited
therapeutic
outcomes.
In
recent
years,
integration
nanotechnology
into
cancer
gained
considerable
attention,
showcasing
notable
advantages
in
drug
delivery,
targeted
accumulation,
controlled
release,
localized
administration.
This
review
focuses
on
nanomaterial-based
immunotherapeutic
strategies,
particularly
development
application
nanocarriers
liposomes,
lipid
nanoparticles,
polymeric
self-assembling
scaffolds.
We
examine
how
can
enhance
while
minimizing
analyze
their
potential
translation.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Abstract
Pyroptosis
provides
a
novel
perspective
for
the
design
of
anti‐tumor
strategies.
However,
when
pyroptosis
reaches
plateau,
its
negative
role
becomes
“defense”
signaling
to
evade
immune
surveillance.
Herein,
triblock
polymeric
micelles
TPT@PIO
NPs
are
reported,
including
hydrophobic
block
backbone
poly
(propylene
sulfide)
(PPS),
side
chain
disulfide
bond‐bearing
indomethacin
(MABHD‐IND),
hydrophilic
poly(ethylene
glycol)
methyl
ether
methacrylate
(OEGMA),
and
an
encapsulated
drug
topotecan
(TPT)
through
forces,
exhibit
excellent
stability
responsiveness
oxidation‐reduction
microenvironment.
This
dual
treatment
mode
utilizes
TPT
trigger
activation
process
uses
IND
eliminate
escape
by
inhibiting
COX‐2/PGE
2
pathway,
ultimately
making
growth
tumors
being
inhibited
via
synergy
chemotherapy
immunotherapy.
Furthermore,
failure
immunosuppressive
network
accelerates
infiltration
CD8
+
T
cells
into
lungs
impedes
generation
tumor
nodules.
The
changes
in
levels
cytokines
caused
memory
effect
enhance
defense
transfer
as
well.
In
general,
ability
regulate
Janus‐faced
nature
acts
indispensable
suppressing
proliferation
metastasis.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 25, 2024
Abstract
Cancer
immunotherapy
has
emerged
as
one
of
the
most
promising
modalities
for
cancer
treatment
providing
hopes
patients
with
significant
advantages
over
traditional
antitumor
therapy
methods.
Supramolecular
assemblies
based
on
host‐guest
interactions
have
been
widely
explored
in
field
delivery
systems.
A
variety
supramolecular
materials
show
unique
features
efficient
drug
encapsulation,
targeting
and
release,
which
are
favorable
to
activate
immune
responses
especially
through
combination
different
strategies.
In
this
review
article,
we
summarize
research
progresses
via
tumor
immunotherapy.
The
construction
various
systems
including
hydrogels,
liposomes,
polymeric
nanoparticles,
encapsulation
delivery,
well
disadvantages
discussed.
perspectives
related
future
developments
also
described.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 11, 2024
In
recent
years,
the
incidence
of
cancer
has
been
increasing
year
by
year,
and
burden
disease
economic
caused
it
worsening.
Although
chemotherapy,
immunotherapy,
targeted
therapy
other
therapeutic
means
continue
to
progress,
they
still
inevitably
have
problems
such
as
high
toxicity
side
effects,
susceptibility
drug
resistance,
price.
Photothermal
photodynamic
demonstrated
considerable
advantages
in
imaging
treatment
due
their
minimally
invasive
selective
nature.
However,
development
constrained
challenges
related
delivery.
times,
delivery
systems
constructed
based
on
supramolecular
chemistry
subject
interest,
particularly
view
compatibility
with
permeability
long
retention
effect
tumors.
Furthermore,
advantage
dissociating
active
ingredient
under
pH,
light
stimuli
makes
them
unique
therapy.
This
paper
reviews
current
status
nanomedicines
therapy,
elucidating
faced
providing
a
theoretical
basis
for
efficient
precise
malignant
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Hypertrophic
scar
(HS)
remains
a
major
challenge
for
clinicians
due
to
unsatisfactory
therapeutic
performance.
Although
inducing
apoptosis
of
HS
fibroblasts
(HSFs)
has
proved
be
an
effective
nonsurgical
treatment
strategy,
potential
chemotherapy
resistance
HSFs
makes
the
development
new
and
efficient
strategies
highly
demanding.
Herein,
ferroptosis‐apoptosis
combined
strategy
is
developed
through
supramolecular
self‐assembly
between
cucurbit[7]uril
(CB[7])
two
bioactive
agents,
dihydroartemisinin
(DHA)
gold
nanoclusters
(AuNCs).
The
resulting
self‐assembled
nanoparticles,
named
CAD
NPs,
showed
high
guest
loading
efficiency
prominent
pH‐responsive
degradability
in
acidic
lysosomes
HSFs.
Importantly,
both
DHA
AuNCs
act
synergistically
generate
excessive
reactive
oxygen
species
lipid
peroxidation,
leading
mitochondrial
damage,
ultimately
concurrent
ferroptosis
on
Upon
further
into
hydrogel
microneedles
facilitate
their
transdermal
delivery,
these
NPs
superior
antiscar
effects
shortening
span
3
weeks
improving
appearance,
as
demonstrated
at
rabbit
ear
model
HS.
present
assembly‐based
provides
innovative
guideline
efficiently
treating
well
other
diseases.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(48), P. 35697 - 35703
Published: Jan. 1, 2024
Two
categories
of
supramolecular
polymer
monomers
were
produced
by
introducing
the
ureidopyrimidone
quadruple-hydrogen
bonding
assemblies
on
calix[4]arene
and
β-cyclodextrin
host
units.
The
adsorption
capacity
these
polymers
for
different
metal
ions
was
investigated
static
adsorption.
results
showed
that
at
pH
=
6
when
equilibrium
reached,
with
calixarene
as
main
body
adsorbed
up
to
99%
Pb
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(12), P. 372 - 372
Published: Dec. 9, 2024
CY1-4,
9-nitropyridine
[2',3':4,5]
pyrimido
[1,2-α]
indole
-5,11-
dione,
is
an
indoleamine
2,3-dioxygenase
(IDO)
inhibitor
and
a
poorly
water-soluble
substance.
It
very
important
to
increase
the
solubility
of
CY1-4
improve
its
bioavailability
therapeutic
effect.
In
this
study,
mesoporous
silica
nano-skeleton
carrier
material
Sylysia
was
selected
as
load
then
drug
delivery
system
(MSNM@CY1-4)
prepared
by
coating
hydrophilic
polymer
Hydroxypropyl
methylcellulose
(HPMC)
lipid
Distearoylphosphatidyl-ethanolamine-poly(ethylene
glycol)
