Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123068 - 123068
Published: Dec. 29, 2024
Language: Английский
Advanced Science, Journal Year: 2023, Volume and Issue: 11(9)
Published: Dec. 25, 2023
Abstract Hepatocellular carcinoma (HCC) is acknowledged as an immunosuppressive neoplasm, whereby the inactive microenvironment facilitates immune tolerance and evasion of HCC. Post‐surgical resected liver cancer exhibits a proclivity for relapse, rendering prevention recurrence challenging it may transpire at any point subsequent to surgery. Among various anti‐recurrence interventions, primary clinical approach involving administration regimens atezolizumab bevacizumab (A+T) deemed most efficacious in reversing tumor microenvironment, albeit still lacking complete satisfaction. Therefore, objective utilize recently developed block copolymer protective carrier two specific monoclonal antibody drugs. Subsequently, modified hemostatic hydrogel will be synthesized application during hepatic The immunotherapy impact this significantly prolonged intensified due combined hemostasis properties controlled release constituents within nanocomposite hydrogel. Furthermore, these hydrogels exhibit remarkable efficacy preventing postoperative wound bleeding substantially enhancing safety resection. This research on system presents novel therapeutic addressing local cancer, potentially offering substantial contribution field surgical treatment future.
Language: Английский
Citations
12
Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)
Published: Sept. 10, 2024
The unavoidable residual tumor tissue from surgery and the strong aggressiveness of cells pose challenges to postoperative treatment patients, accompanied by in situ recurrence decreased quality life. Therefore, there is an urgent need explore appropriate therapeutic strategies remove after inhibit metastasis surgery. In recent years, with rapid development biomedical materials, study local delivery systems as agents has gradually attracted attention researchers. Injectable situ-forming hydrogel a locally administered agent injected solution that can be loaded various rapidly gels form semi-solid gel at site. This type tightly fills surgical site covers irregular excision surfaces. this paper, we review advances application injectable hydrogels therapy, focusing on matrix materials its different types tumors, well discussing prospects clinical application.
Language: Английский
Citations
4
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 27, 2024
Gastrointestinal tumors are the main causes of death among patients. These mainly diagnosed in advanced stages and their response to therapy is unfavorable. In spite development conventional therapeutics including surgery, chemotherapy, radiotherapy immunotherapy, treatment these still challenging. As a result, new based on (nano)biotechnology have been introduced. Hydrogels polymeric 3D networks capable absorbing water swell with favorable biocompatibility. application hydrogels different human diseases, wide cancer has improved because potential drug gene delivery, boosting chemotherapy immunotherapy as well vaccines. The current review focuses role gastrointestinal tumors. provide delivery drugs (both natural or synthetic compounds co-delivery) along delivery. Along stimulate phototherapy (photothermal photodynamic therapy) suppression Besides, ability for induction immune-related cells such dendritic can boost immunotherapy. For more specific therapy, stimuli-responsive types thermo- pH-sensitive self-healing site Moreover, promising diagnosis, circulating tumor cell isolation detection biomarkers tumors, highlighting importance clinic. Hence, diagnostic therapeutic tools gastrointestimal
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140442 - 140442
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
Impaired chronic wounds are a common complication of diabetes. Inhibited angiogenesis and dysfunctional inflammation render diabetic wound healing critical challenge. Herein, sustainable therapeutic composite hydrogel is presented for healing, consisting cocktail formulation anti-inflammatory local anesthetic nanoparticles incorporated into hydrogel. The surface-modified drug loaded the biocompatible hydrogels cross-linked with gel precursor to enhance structure. delivery system achieves more than 90% release, total therapy duration tunable from 4 72 h. Through long-lasting analgesic effects hydrogel, swiftly transitioned proliferation phase, augmenting survival migration keratinocytes facilitating neovascularization collagen alignment in wounds. These significantly improve rate skin regeneration process, achieving that 17 times untreated This study demonstrates platform promising rapid
Language: Английский
Citations
0
World Journal of Gastrointestinal Surgery, Journal Year: 2025, Volume and Issue: 17(3)
Published: Feb. 24, 2025
The high postoperative recurrence rate remains a major challenge in the treatment of hepatocellular carcinoma (HCC) following resection. Increasing research has been delved into investigating role neoadjuvant therapy on prognosis resectable HCC. Recent trends combination with molecularly targeted agents and immune checkpoint inhibitors have significantly improved efficacy systemic antitumor treatments, yielding survival benefits exceeding 40%. Neoadjuvant for HCC, whether based locoregional therapies, or their combination, emerged as promising direction. However, there matter debate therapy. In this review, we summarize discuss progress challenges HCC over past five years from perspective Chinese guidelines to provide new insights future directions field.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 23, 2025
Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation insufficient endogenous H O release ROS weakly acidic conditions. To realize their synergistic effects, nanozymes, along photothermal agent IR820, are co‐assembled into low‐melting point agarose solution, forming a thermosensitive nanozyme‐based hydrogel (CuMnOx@CuO @IR820 hydrogel, CMCI Gel), which facilitates controlled drug delivery exerts enhanced efficiency under low‐temperature therapy (LTPTT, <48 °C). In vitro vivo studies demonstrated that Gel effectively ablated cells range bacteria, including drug‐resistant bacteria like MRSA . Furthermore, it reduces inflammation, promotes vascular regeneration collagen deposition, accelerates healing. injectability thermosensitivity allow localized treatment, minimizing systemic side effects. Overall, benefits highlight as promising adjunctive prevent postsurgery infection.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: May 10, 2025
Radiotherapy, as an important means of treating hepatocellular carcinoma (HCC), has shown unique therapeutic advantages, especially in patients who are unable to undergo surgery or transplantation. It mainly includes external radiotherapy, transarterial radioembolization and intratumoral radioactive particle implantation. However, under the influence factors such hypoxic characteristics liver tumor microenvironment radioresistance cells, effect radiotherapy may be unstable cause side effects, affecting quality life patients. In recent years, with development nanotechnology, drug delivery systems based on micro-nanomaterials have provided new solutions for improving HCC. Despite this, application micro-nano treatment HCC still faces some challenges, including vivo safety metabolism materials. This article reviews latest progress materials HCC, their radiosensitization clinical translation potential. systematically analyzes role internal sensitization radioimmunotherapy explores advantages
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 16, 2025
Adoptive natural killer cell therapy (ANKCT) harbors great potential for combating postsurgical hepatocellular carcinoma (HCC) recurrence, but its efficacy is limited by tumor microenvironment (TME)-meditated repression on NK function and insufficient homing to sites. Therefore, herein we develop a nanocomposite sprayable self-gelling powder enabling liver-localized codelivery of three FDA-approved drugs including calcitriol (Cal), gemcitabine (Gem), tazemetostat (Taz) address these challenges. This can be laparoscopically spread liver wound sites, where it rapidly absorbs interfacial liquid form bulk adhesive pressure-resistant hydrogel in situ, implying application minimally surgery. Moreover, resection bed significantly sensitizes allogenic EpCAM chimeric antigen receptor modified-NK-92 (EpCAM-CAR-NK) infusion prevent HCC recurrence orthotopic Heap1-6 tumor-bearing patient-derived xenograft (PDX) murine models. Additionally, this allow an effective hemostatic effect rat porcine models due powerful tissue adhesion-seal erythrocyte-aggregating effects. Altogether, our newly developed sensitize ANKCT combat manner compatible with surgical treatment HCC.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 13, 2024
Background Cancer immunotherapy has made significant progress in recent years, with numerous studies worldwide. Immunotherapy had a transformative impact on oncology and autoimmune diseases. In the biomedical arena, hydrogels good properties are widely used cancer immunotherapy. Our study bibliometrics to analyze changing trends using for Methods From 2013 2023, systematic search was conducted Web of Science Core Collection database identify reviews articles discussing applications The software CiteSpace visually perform bibliometric analysis terms research trends, countries, institutions, authors, journals, keywords. Individual authors’ productivity assessed Lotka’s law. most relevant publication sources were identified by Bradford’s Results A total 422 English-language publications related collected. number annual increased rapidly after 2021 remained constant past two years. China published this field. institution maximum Chinese Academy Sciences China. Chen. Q prolific author, Liu. Z second author. journal contributions, “Biomaterials” highest (n = 30). Biomaterials, Advanced Functional Materials Journal Controlled Release influential journals. Keyword revealed that immunotherapy, drug delivery, immunogenic cell death, tumor microenvironment, injectable hydrogels, immune checkpoint blockade primary hotspots. 3 adoptive T-cell therapy, black phosphorus, capture, adaptive photodynamic sustained release hotspots summarizes objective providing reference potential researchers Conclusion This shows trend provides avenue future investigation into current concerns within
Language: Английский
Citations
2