Metabolism: a potential regulator of neutrophil fate DOI Creative Commons

Zhou Yipeng,

Chao Cao, Ranran Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Neutrophils are essential components of the innate immune system that defend against invading pathogens, such as bacteria, viruses, and fungi, well having regulatory roles in various conditions, including tissue repair, cancer immunity, inflammation modulation. The function neutrophils is strongly related to their mode cell death, different types death involve cellular molecular alterations. Apoptosis, a non-inflammatory programmed type most common neutrophils, while other modes NETOsis, necrosis, necroptosis, autophagy, pyroptosis, ferroptosis, have specific neutrophil regulation. Immunometabolism refers energy substance metabolism cells, profoundly influences fate function. Intercellular intracellular signal transduction modulate metabolism, which can, turn, alter activities by influencing signaling pathways. In this review, we compile an extensive body evidence demonstrating role forms death. review highlights intricate metabolic characteristics interplay with

Language: Английский

Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages DOI Creative Commons

Shian Hu,

Zehua Yang, Ling Li

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(1), P. 236 - 236

Published: Jan. 1, 2024

Salvianolic acid B (Sal B) is the primary water-soluble bioactive constituent derived from roots of Salvia miltiorrhiza Bunge. This research was designed to reveal potential mechanism Sal anti-liver injury perspective macrophages. In our lipopolysaccharide-induced M1 macrophage model, showed a clear dose-dependent gradient inhibition trend type. Moreover, downregulated expression lactate dehydrogenase A (LDHA), while overexpression LDHA impaired B’s effect inhibiting polarization. Additionally, this study revealed that exhibited inhibitory effects on lactylation process histone H3 lysine 18 (H3K18la). ChIP-qPCR analysis, observed drive reduction in H3K18la levels promoter region LDHA, NLRP3, and IL-1β genes. Furthermore, vivo experiments has good alleviating CCl4-induced liver injury. An examination tissues Kupffer cells isolated those proved affects polarization macrophages level lactylation. Together, data by downregulating treatment

Language: Английский

Citations

9
New insights into constitutive neutrophil death DOI Creative Commons
Tong Chen, Qian Ren, Fengxia Ma

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 12, 2025

Neutrophils undergo rapid aging and death known as constitutive or spontaneous death. Constitutive neutrophil (CND) contributes to homeostasis inflammation resolution. CND has long been considered be apoptotic until our findings reveal that it was a heterogeneous combination of diverse Furthermore, dead neutrophils retain functional roles via multiple manners. This review provides an overview current research on the mechanism modulation CND. More noteworthy, we also summarize after-death events neutrophils. The fate can changed under pathological conditions, so involvement in diseases CND-related therapeutic strategies are addressed.

Language: Английский

Citations

1
Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity DOI Creative Commons

Hai‐Yue Tu,

Haoyu Ren, Junjie Jiang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(8)

Published: Dec. 3, 2023

Abstract Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, eventual death. Neutrophils undergo different death pathways depending on their interactions with microbes external environmental cues. has significant physiological implications leads to distinct immunological outcomes. This review discusses the multifarious neutrophil pathways, including apoptosis, NETosis, pyroptosis, necroptosis, ferroptosis, outlines effects immune responses disease progression. Understanding multifaceted aspects death, intersections among signaling ramifications immunity will help facilitate development novel therapeutic methods.

Language: Английский

Citations

20
In situ neutrophil apoptosis and macrophage efferocytosis mediated by Glycyrrhiza protein nanoparticles for acute inflammation therapy DOI
Xiong Liu,

Xiangjun Ou,

Tiantian Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 215 - 230

Published: March 28, 2024

Language: Английский

Citations

7
The diverse roles of neutrophils from protection to pathogenesis DOI
Rana Herro, H. Leighton Grimes

Nature Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

Citations

7
Neutrophil diversity and function in health and disease DOI Creative Commons

F Zhang,

Yidan Xia,

Jiayang Su

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 5, 2024

Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.

Language: Английский

Citations

6
Current perspectives and trends of neutrophil extracellular traps in organ fibrosis: a bibliometric and visualization study DOI Creative Commons
Yanbo Li,

Zheng-Min Cao,

Jing Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

New insights into the role of immune responses in fibrosis process provide valuable considerations for treatment organ fibrotic diseases. Neutrophil extracellular traps (NETs) represent a novel understanding neutrophil functions, and their involvement diseases has garnered widespread attention recent years. This study aims to conduct bibliometric analysis literature review focusing on mechanisms by which NETs participate Specifically, we utilized dataset that includes 220 papers published 139 journals, originating from 425 organizations across 39 countries, with total citation count 12,301. Keyword co-occurrence indicates research focus is likely center NETosis, responses, thrombosis, inflammation, tissue damage associated NET formation. In conclusion, our findings underscore current status emerging trends related fibrosis, offering contribute pathogenesis diseases, as well potential therapeutic strategies.

Language: Английский

Citations

0
The roles of neutrophils in cardiovascular diseases DOI Creative Commons
Yanjie Lian, Xiaolei Lai, Cong Wu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

The immune response plays a vital role in the development of cardiovascular diseases (CVDs). As crucial component innate system, neutrophils are involved initial inflammatory following injury, thereby inducing subsequent damage and promoting recovery. Neutrophils exert their functional effects tissues through various mechanisms, including activation formation neutrophil extracellular traps (NETs). Once activated, recruited to site where they release mediators cytokines. This study discusses main mechanisms associated with activity proposes potential new therapeutic targets. In this review, we systematically summarize diverse phenotypes disease regulatory different modes cell death, focus on relevance CVDs, atherosclerosis, acute coronary syndrome, myocardial ischemia/reperfusion hypertension, atrial fibrillation, heart failure, viral myocarditis. Finally, also emphasize preclinical/clinical translational significance neutrophil-targeted strategies.

Language: Английский

Citations

0
Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis DOI
Zhaoran Wang, Yi Jiao,

Wenya Diao

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: March 28, 2025

Language: Английский

Citations

0
Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases DOI
Hirotsugu Oda, Alessandro Annibaldi, Daniel L. Kastner

et al.

Annual Review of Immunology, Journal Year: 2025, Volume and Issue: 43(1), P. 313 - 342

Published: April 25, 2025

Metazoans have evolved innate antimicrobial defenses that promote cellular survival and proliferation. Countering the inevitable molecular mechanisms by which microbes sabotage these pathways, multicellular organisms rely on an alternative, perhaps more ancient, strategy is immune equivalent of suicide bombing: Infection triggers cell death programs summon localized or even systemic inflammation. The study human genetics has now unveiled a level complexity refutes naive view merely blunt instrument evolutionary afterthought. To contrary, findings from patients with rare diseases teach us death–induced inflammation sophisticated, tightly choreographed process. We herein review emerging body evidence describing group illnesses—inborn errors death, define many building blocks regulatory elements controlling in humans—and provide possible road map to countering this process across spectrum common illnesses.

Language: Английский

Citations

0