EBioMedicine, Journal Year: 2024, Volume and Issue: 111, P. 105502 - 105502
Published: Dec. 10, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 16, 2024
Abstract Histone post-translational modifications (HPTMs), as one of the core mechanisms epigenetic regulation, are garnering increasing attention due to their close association with onset and progression diseases potential targeted therapeutic agents. Advances in high-throughput molecular tools abundance bioinformatics data have led discovery novel HPTMs which similarly affect gene expression, metabolism, chromatin structure. Furthermore, a growing body research has demonstrated that histone also play crucial roles development various diseases, including cancers, cardiovascular infectious psychiatric disorders, reproductive system diseases. This review defines nine modifications: lactylation, citrullination, crotonylation, succinylation, SUMOylation, propionylation, butyrylation, 2-hydroxyisobutyrylation, 2-hydroxybutyrylation. It comprehensively introduces modification processes these HPTMs, transcription, replication, DNA repair recombination, structure, well involvement promoting occurrence clinical applications targets biomarkers. Moreover, this provides detailed overview HPTM inhibitors targeting emerging strategies treatment multiple while offering insights into future prospects challenges. Additionally, we briefly introduce techniques field research.
Language: Английский
Citations
18
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(3), P. 167659 - 167659
Published: Jan. 7, 2025
Language: Английский
Citations
1
Clinical Science, Journal Year: 2025, Volume and Issue: 139(02), P. 151 - 169
Published: Jan. 1, 2025
Lactylation, a post-translational modification, has been linked to gene transcription regulation through epigenetic modulation in various pathophysiological processes. The lactylation regulatory proteins, known as writers, erasers, and readers, govern their dynamics by adding, removing, recognizing lactyl groups on proteins. Macrophages, cells of the immune system, maintain homeostasis, responding dynamically diverse internal external stimuli. Emerging researches unveil that lactylation, inducing macrophage activation polarization, affects functionality pathological conditions such inflammation, tumor microenvironment, fibrosis. Evidence progressively indicates lactate-driven alterations levels within macrophages can influence pathogenesis numerous diseases. This review aims systematically summarize research progress macrophages, explore its functions mechanisms which contributes pathology different disease phenotypes, propose future directions along with potential diagnostic therapeutic strategies.
Language: Английский
Citations
1
Experimental Cell Research, Journal Year: 2024, Volume and Issue: 440(2), P. 114135 - 114135
Published: June 18, 2024
Language: Английский
Citations
6
Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107579 - 107579
Published: Jan. 5, 2025
The incidence of metabolic diseases-hypertension, diabetes, obesity, dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis-is increasing annually, imposing a significant burden on both human health the social economy. occurrence development these diseases are closely related to disruption ion homeostasis, which is crucial for maintaining cellular functions equilibrium. However, specific mechanism homeostasis in still unclear. This article reviews role pathogenesis assesses its potential as therapeutic target. Furthermore, explores pharmacological strategies that target channels transporters, including existing drugs emerging under development. Lastly, discusses direction future strategies, possibility gene therapy targeting personalized using novel biomarkers. In summary, provides new perspective approach treatment diseases.
Language: Английский
Citations
0
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 15, 2025
Myocardial fibrosis (MF) is a common pathological manifestation of many cardiovascular diseases, such as myocardial infarction, ischemia, and sudden cardiac death. It characterized by excessive proliferation activation fibroblasts, transformation into myofibroblasts, and, eventually, deposition the extracellular matrix, resulting in heart damage. Currently, modern drugs angiotensin-converting enzyme inhibitors, diuretics, β-blockers can improve clinical treatment, but their therapeutic effect on this disease limited, with obvious side effects high cost. Traditional Chinese medicine (TCM) has advantages multiple targets, low cost, few effects. medicines, Salvia miltiorrhiza, Astragalus, Angelica extracts, patent Qiliqiangxin capsules, Shenqi Yiqi dropping pills, Tongxinluo fibrosis. In review, current Western methods for treating are discussed. The signaling pathways targets involved treatment This review aimed to provide valuable insights ideas both basic research
Language: Английский
Citations
0
Life Sciences, Journal Year: 2025, Volume and Issue: 364, P. 123443 - 123443
Published: Feb. 4, 2025
Language: Английский
Citations
0
Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116879 - 116879
Published: March 1, 2025
Language: Английский
Citations
0
EBioMedicine, Journal Year: 2024, Volume and Issue: 111, P. 105502 - 105502
Published: Dec. 10, 2024
Language: Английский
Citations
3