Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: April 21, 2025
The
deposition
of
drug-loaded
nanoparticles
within
the
skin
structure
has
been
a
challenge
due
to
inexorable
barrier
function.
Unless
specific
like
liposomes
and
lipid-based
related
vesicles,
most
cannot
penetrate
epidermal
layers
by
themselves.
This
is
reason
why
microneedle-based
systems
are
nowadays
straightforward
in
research.
They
can
greatly
bypass
stratum
corneum
deposit
supramolecular
cargo
entities
dermal
layers,
which
perform
features
such
as
drug-controlled
release,
targeting
or
stimuli-responsive
behaviors.
At
this
point,
after
more
than
20
years
research
using
nanoparticle-microneedle
combination
all
positive
results,
clinical
experience
still
so
limited.
Therefore,
how
it
possible
that
everlasting
promise
translation
these
not
reached
real
practice?
In
piece
work,
based
on
authors'
review,
series
limiting
factors
regulatory
framework
guidelines
identified
discussed,
while
highlighted
revolutionary
advances
biomedical
field
3D-printing
technology
microfluidics
will
contribute
accelerate
nanoparticle-microneedle-based
devices
make
their
use
entrance
market.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(12)
Published: Jan. 15, 2024
Abstract
Point‐of‐care
(POC)
has
the
capacity
to
support
low‐cost,
accurate
and
real‐time
actionable
diagnostic
data.
Microneedle
sensors
have
received
considerable
attention
as
an
emerging
technique
evolve
blood‐based
diagnostics
owing
their
direct
painless
access
a
rich
source
of
biomarkers
from
interstitial
fluid.
This
review
systematically
summarizes
recent
innovations
in
microneedle
with
particular
focus
on
utility
POC
personalized
medicine.
The
integration
various
sensing
techniques,
mostly
electrochemical
optical
sensing,
been
established
diverse
architectures
“lab‐on‐a‐microneedle”
platforms.
tailored
geometries,
mechanical
flexibility,
biocompatibility
are
constructed
variety
materials
fabrication
methods.
Microneedles
categorized
into
four
types:
metals,
inorganics,
polymers,
hydrogels,
elaborated
state‐of‐the‐art
bioengineering
strategies
for
minimally
invasive,
continuous,
multiplexed
sensing.
employed
detect
wide
range
electrolytes,
metabolites,
polysaccharides,
nucleic
acids,
proteins
drugs.
Insightful
perspectives
outlined
biofluid,
microneedles,
biosensors,
devices,
theragnostic
instruments,
which
depict
bright
future
upcoming
intelligent
health
management.
ECS Sensors Plus,
Journal Year:
2024,
Volume and Issue:
3(1), P. 017001 - 017001
Published: March 1, 2024
The
rapid
growth
of
urbanisation
has
brought
about
various
health
concerns
for
citizens
living
in
urban
environments.
Sedentary
lifestyles,
increased
pollution
levels,
and
high
levels
stress
have
become
prevalent
issues
affecting
the
overall
well-being
populations.
In
recent
years,
emergence
smart
wearable
devices
offered
a
promising
avenue
to
address
these
promote
healthier
lifestyles.
This
review
evaluatse
effectiveness
wearables
mitigating
improving
lifestyles
citizens.
involves
50
relevant
peer-reviewed
studies
supporting
literature
from
electronic
databases
PubMed,
Ovid,
Web
Science,
Scopus.
Results
indicate
that
potential
positively
impact
by
promoting
physical
activity,
tracking
vital
signs,
monitoring
sleep
patterns,
providing
personalised
feedback
recommendations
activity
levels.
Furthermore,
can
help
individuals
manage
enhance
self-awareness,
foster
behaviours.
However,
also
identifies
several
challenges,
including
accuracy
reliability
data,
user
engagement
adherence,
ethical
considerations
regarding
data
privacy
security.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(4), P. 358 - 358
Published: April 6, 2024
In
recent
years,
the
proliferation
of
wearable
healthcare
devices
has
marked
a
revolutionary
shift
in
personal
health
monitoring
and
management
paradigm.
These
devices,
ranging
from
fitness
trackers
to
advanced
biosensors,
have
not
only
made
more
accessible,
but
also
transformed
way
individuals
engage
with
their
data.
By
continuously
signs,
physical-based
biochemical-based
such
as
heart
rate
blood
glucose
levels,
technology
offers
insights
into
human
health,
enabling
proactive
rather
than
reactive
approach
healthcare.
This
towards
personalized
empowers
knowledge
tools
make
informed
decisions
about
lifestyle
medical
care,
potentially
leading
earlier
detection
issues
tailored
treatment
plans.
review
presents
fabrication
methods
flexible
applications
care.
The
potential
challenges
future
prospectives
are
discussed.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Microneedle
(MN)
sensors
have
great
promise
for
food
safety
detection,
but
the
rapid
preparation
of
MNs
surface-enhanced
Raman
scattering
(SERS)
with
tunable
and
homogeneous
nanoparticles
remains
a
challenge.
To
address
this,
SERS
sensor
gold
nanoparticles@polydopamine@poly(methyl
methacrylate)
MN
(AuNPs@PDA@PMMA-MN)
was
developed.
The
extended-Derjaguin−Landau−Verwey−Overbeek
theory
applied
to
calculate
interaction
energy
between
AuNPs
PDA.
It
confirmed
that
an
appropriate
centrifugal
force
could
be
utilized
overcome
electrostatic
repulsion
Together
adhesion
PDA,
can
therefore
uniformly
densely
deposited
on
substrate.
AuNPs@PDA@PMMA-MN
had
enhancement
factor
up
1.74
×
106
R6G.
Furthermore,
selective
detection
putrescine
cadaverine
successfully
constructed
by
modifying
4-mercaptobenzaldehyde
(4-MBA)
substrates.
This
quantitatively
detect
in
meat.
has
been
situ
real
meat
samples.
advantages
facile
fabrication,
high
sensitivity,
specificity,
online,
capability.
is
expected
applications
quality
testing,
environmental
monitoring,
disease
diagnosis.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
Chemosensors,
Journal Year:
2025,
Volume and Issue:
13(2), P. 68 - 68
Published: Feb. 15, 2025
Microneedles
(MNs)
are
miniature
medical
devices,
presented
as
an
array
of
micro-scale
needles,
each
under
1
mm
in
height
with
sharp
tips.
MN
technology
is
becoming
a
diagnostic
platform
associated
several
qualities:
no
pain
and
risk
infection,
offering
accuracy,
comfort,
usability.
Monitoring
biomarkers
interstitial
fluid
(ISF)
real
time
crucial
for
tracking
changes
metabolism
assisting
the
early
diagnosis
chronic
illnesses.
Some
examples
sensors
summarized
here:
real-time
sensing
two
metabolites
(lactate
glucose
or
alcohol
glucose),
transdermal
tracing
pH,
Na+,
K+,
Ca2+,
Li+,
Cl−,
methotrexate
(MTX)
monitoring,
tyrosinase
enzyme
melanoma
biomarker,
integration
CRISPR
nucleic
acid
analysis,
monitoring
plant
sap
pH
leaves
plants.
The
challenges
to
be
addressed
realize
transition
widespread
One
Health
solutions
analyzed.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(5), P. 2294 - 2309
Published: April 24, 2024
Bioanalyte
collection
by
blood
draw
is
a
painful
process,
prone
to
needle
phobia
and
injuries.
Microneedles
can
be
engineered
penetrate
the
epidermal
skin
barrier
collect
analytes
from
interstitial
fluid,
arising
as
safe,
painless,
effective
alternative
hypodermic
needles.
Although
there
are
plenty
of
reviews
on
various
types
microneedles
their
use
drug
delivery
systems,
lack
systematization
application
polymeric
for
diagnosis.
In
this
review,
we
focus
current
state
art
field,
while
providing
information
safety,
preclinical
clinical
trials,
market
distribution,
outline
what
believe
will
future
health
monitoring.
