Recent advances and perspectives of MicroNeedles for biomedical applications

Biophysical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Microneedles (MN) technology has emerged as a transformative tool within the biomedical field, offering innovative solutions to challenges in drug delivery, diagnostics, and therapeutic applications. This review article provides an in-depth exploration of diverse perspectives applications MNs, shedding light on their pivotal role shaping future research clinical practice. It begins by elucidating fundamental principles MNs: design, fabrication techniques, materials, highlighting capacity for minimally invasive access skin underlying tissues. These attributes have driven advancements transdermal facilitating precise controlled administration therapeutics, vaccines, biologics, thus improving patient compliance treatment outcomes. Furthermore, this investigates growing range including biomarker extraction, interstitial fluid (ISF) analysis, continuous glucose monitoring. MNs enable real-time monitoring biochemical markers potential revolutionize disease personalized medicine, wellness Their compatibility with microfluidic systems further enhances point-of-care testing. serves comprehensive guide, breadth opportunities leveraging improve healthcare outcomes emphasizing need continued development dynamic field.

Language: Английский

Morphology Design and Precision Control of Microneedles by PμSL 3D Printing

Polymers, Journal Year: 2025, Volume and Issue: 17(10), P. 1351 - 1351

Published: May 15, 2025

Microneedles (MNs) hold significant potential for applications in transdermal drug delivery and biosensing. However, when traditional 3D printing technology is used their manufacture, a substantial deviation output size occurs. The effects of various parameters on the morphology MNs produced through microscale remain unclear. This study investigated relationship between design fabrication acrylic resin forms via projection microstereolithography (PµSL) system. Modifying shape array configurations elucidates causes proposes control strategy. particularly prototyping mold manufacturing relevant fields. indicates that layer thickness 10 µm optimally balances efficiency clinical conversion requirements. Additionally, an exposure intensity 65 mW/cm2 achieves both high fidelity appropriate base size. angle significantly influences mechanical properties MNs. diameter aspect ratio solid correlate with dimensional stability. Clinically, conical or quadrilateral defined are recommended. A critical spacing (≥40 µm) optimal arrangement MN arrays were established. specific vertical hollow ensure precision micropore wall thickness. approach offers theoretical insights process essential high-precision, customizable engineering design.

Language: Английский

Gold-modified silicon microneedles for real-time SERS analysis and drug delivery at single-cell resolution

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 114178 - 114178

Published: June 1, 2025

Language: Английский