ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
8(1), P. 446 - 456
Published: Dec. 31, 2024
The
multiple
enzymatic
properties
of
the
Au3+-modified
metal–organic
framework
(Au3+-MOFs)
have
made
it
a
functional
catalytic
system
for
antitumor
treatment.
However,
in
face
insufficient
substrates
tumor
tissue,
is
still
impossible
to
achieve
efficient
treatment
tumors.
Herein,
Au3+-MOFs
loaded
with
hyaluronic
acid
(HA)-modified
calcium
peroxide
nanoparticles
(CaO2
NPs)
were
used
construct
nanozyme
(Au3+-MOF/CaO2/HA)
substrate
self-supplied
and
parallel
catalytic/calcium-overload-mediated
therapy
cancer.
Due
specific
targeted
ability
retention
(EPR)
effect
HA,
built
can
effectively
accumulate
at
site.
oxidase-like
(OXD)
activity
peroxidase-like
(POD)
Au3+-MOFs,
superoxide
radical
anion
(O2•–)
hydroxyl
radicals
(·OH)
cooperatively
formed
(PCT)
Subsequently,
CaO2
NPs
decomposed
Ca2+,
H2O2,
O2
weak
acidic
environment
microenvironment
(TME).
Thus,
self-supplementation
as
well
H2O2
was
achieved,
alleviating
deficiency
Au3+-MOF
substrate.
In
addition,
Ca2+
lead
oxidative
stress
calcification
calcium-overload-mediated
(COMT)
promote
necrosis
vivo.
An
effective
paradigm
PCT/COMT
self-supplying
has
been
successfully
established
considerably
enhanced
therapeutic
efficacy.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1420 - 1420
Published: Nov. 6, 2024
This
review
explores
the
role
of
photodynamic
therapy
(PDT)
as
an
adjunctive
treatment
for
cancers,
with
a
focus
on
its
potential
to
enhance
effects
established
therapies
like
chemotherapy,
surgery,
and
radiotherapy.
Given
limitations
conventional
cancer
treatments,
PDT's
ability
improve
therapeutic
outcomes
through
combination
strategies
is
examined.
In
cancers
such
lung,
breast,
cholangiocarcinoma,
cervical,
PDT
shows
promise
in
enhancing
response
rates,
reducing
recurrence,
minimizing
adverse
when
used
alongside
standard
modalities.
study
highlights
current
findings
mechanisms
complementing
augmenting
surgical
precision,
radiotherapeutic
effects,
thus
offering
multi-faceted
approach
treatment.
Additionally,
insights
into
clinical
application
these
emphasize
tumor
resistance
supporting
more
effective,
personalized
care.
By
providing
overview
synergistic
applications
across
diverse
types,
this
underscores
emerging
significance
oncology
tool
address
traditional
limitations.
Ultimately,
aims
inform
inspire
researchers
clinicians
seeking
refine
innovate
integration,
contributing
advancement
treatments.
Applying
cold
to
a
bone
injury
can
aid
healing,
though
its
mechanisms
are
complex.
This
study
investigates
how
therapy
impacts
repair
optimize
healing.
Cold
was
applied
rodent
model,
with
physiological
responses
analyzed.
Vasoconstriction
mediated
by
an
increase
in
TRP
channels,
TRPA1
(p=0.012)
and
TRPM8
(p<0.001),
within
cortical
defects
enhancing
sensory
response
blood
flow
regulation.
exposure
also
elevated
hypoxia
(p
<
0.01)
VEGF
expression
0.001),
promoting
angiogenesis
vital
for
regeneration.
Increased
of
osteogenic
proteins
PGC-1α
=
0.039)
RBM3
(p<0.008)
suggests
stimulated
reparative
processes.
Enhanced
osteoblast
differentiation
ALP
presence
at
days
5
(three-fold,
p=0.014)
10
(two-fold,
p=0.010)
were
observed,
along
increased
osteocalcin
(OCN)
day
p
0.010)
indicating
mature
osteoblasts
capable
mineralization.
These
findings
highlight
therapy's
multifaceted
effects
on
repair,
offering
insights
therapeutic
strategies.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
Abstract
The
nervous
and
immune
systems
are
closely
interconnected,
influence
the
onset
progress
of
various
diseases.
Accordingly,
understanding
interaction
neural
system
becomes
very
important
for
treatment
intractable
diseases
with
analysis
therapeutic
mechanisms,
such
as
autoimmune
diseases,
neurodegenerative
cancers,
so
on.
conventional
immunomodulation
treatments
have
been
mainly
carried
out
by
drug
administration,
but
they
suffered
from
systemic
negative
side‐effects
only
limited
effects
on
specific
disease.
In
this
Perspective,
photonic
nanomaterials
devices
reviewed
discussed
digitally
controlled
neurostimulating
photomedicine
via
photobiomodulation
optogenetics
unique
viewpoint
neuro‐immune
cross‐talks.
prospects
perspectives
to
integrate
advanced
wearable
implantable
healthcare
also
provided
highlighted
revolutionize
strategies
systems,
optimize
protocols
futuristic
digital
photomedicine.
This
approach
will
fields
neurostimulation
regulation
further
clinical
applications.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2045 - 2045
Published: Sept. 9, 2024
Applying
cold
to
a
bone
injury
can
aid
healing,
though
its
mechanisms
are
complex.
This
study
investigates
how
therapy
impacts
repair
optimize
healing.
Cold
was
applied
rodent
model,
with
the
physiological
responses
analyzed.
Vasoconstriction
mediated
by
an
increase
in
transient
receptor
protein
channels
(TRPs),
potential
ankyrin
1
(TRPA1;
Biomaterials Research,
Journal Year:
2024,
Volume and Issue:
28
Published: Jan. 1, 2024
Photomedicine,
which
utilizes
light
for
therapeutic
purposes,
has
several
hurdles
such
as
limited
tissue
penetration
short-wavelength
and
inadequate
deep
efficacy
long-wavelength
light.
Photon
energy
upconversion
(UC)
reveals
promise
in
photomedicine
because
it
enables
the
conversion
of
lower-energy
photons
into
higher-energy
photon.
Lanthanide
(Ln)-based
inorganic
UC
system
been
extensively
studied
but
faces
challenges,
including
high
excitation
laser
power
density,
intrinsically
subpar
quantum
efficiency,
potential
biotoxicity.
Recently,
an
organic-based
triplet–triplet
annihilation
(TTA-UC)
emerged
a
novel
due
to
its
prolonged
emission
lifetime
upon
low
exceptional
yield.
In
this
study,
we
developed
water-dispersible
hyaluronic
acid
(HA)-conjugated
polycaprolactone
(PCL)
nanoparticles
loaded
with
TTA-UC
chromophores
(HA-PCL/UC
NPs),
allow
deeper
by
converting
red
(635
nm)
blue
(470
noninvasive
transdermal
delivery.
HA-PCL/UC
NPs
demonstrated
1.6%
yield
distilled
water,
improved
cellular
imaging
HeLa
cells,
effectively
penetrated
porcine
skin,
showing
upconverted
Our
strategy
holds
significant
next-generation
platform
bioimaging,
photo-triggered
drug
delivery,
photodynamic
therapy,
ultimately
advancing
targeted
effective
interventions.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
8(1), P. 446 - 456
Published: Dec. 31, 2024
The
multiple
enzymatic
properties
of
the
Au3+-modified
metal–organic
framework
(Au3+-MOFs)
have
made
it
a
functional
catalytic
system
for
antitumor
treatment.
However,
in
face
insufficient
substrates
tumor
tissue,
is
still
impossible
to
achieve
efficient
treatment
tumors.
Herein,
Au3+-MOFs
loaded
with
hyaluronic
acid
(HA)-modified
calcium
peroxide
nanoparticles
(CaO2
NPs)
were
used
construct
nanozyme
(Au3+-MOF/CaO2/HA)
substrate
self-supplied
and
parallel
catalytic/calcium-overload-mediated
therapy
cancer.
Due
specific
targeted
ability
retention
(EPR)
effect
HA,
built
can
effectively
accumulate
at
site.
oxidase-like
(OXD)
activity
peroxidase-like
(POD)
Au3+-MOFs,
superoxide
radical
anion
(O2•–)
hydroxyl
radicals
(·OH)
cooperatively
formed
(PCT)
Subsequently,
CaO2
NPs
decomposed
Ca2+,
H2O2,
O2
weak
acidic
environment
microenvironment
(TME).
Thus,
self-supplementation
as
well
H2O2
was
achieved,
alleviating
deficiency
Au3+-MOF
substrate.
In
addition,
Ca2+
lead
oxidative
stress
calcification
calcium-overload-mediated
(COMT)
promote
necrosis
vivo.
An
effective
paradigm
PCT/COMT
self-supplying
has
been
successfully
established
considerably
enhanced
therapeutic
efficacy.
