Piezocatalysts and Piezo‐Photocatalysts: From Material Design to Diverse Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: June 19, 2024

Abstract Piezocatalysis and piezo‐photocatalysis technology is a continuously developing catalytic based on the piezoelectric effect of catalysts, which breaks barrier between mechanical chemical energy. The polarization field formed by deformation materials proven to effectively manipulate band structures, improve separation electron‐hole pairs enhance activity, thus alleviating energy crises environmental issues. Herein, this review first introduces piezocatalysis piezo‐photocatalysis, comprehensively summarizes synthesis methods piezo(photo)catalysis materials, analyzes discusses measures optimize performance piezo(photo)catalysts. following systematically characteristics development current main piezo(photo)catalytic systems, application principles calculations in combination with practical researches. Subsequently, progress remediation, conversion, biomedical therapy fields presented. In end, challenges, direction, future prospects are prospected.

Language: Английский

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Employing Piezoelectric Mg²⁺‐Doped Hydroxyapatite to Target Death Receptor‐Mediated Necroptosis: A Strategy for Amplifying Immune Activation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 22, 2024

Abstract Although immunogenic cell death (ICD) inducers evidently enhance the effectiveness of immunotherapy, their potential is increasingly restricted by development apoptosis resistance in tumor cells, poor immunogenicity, and low T‐cell immune responsiveness. In this study, for first time, piezoelectrically catalyzed Mg 2+ ‐doped hydroxyapatite (Mg‐HAP) nanoparticles, which are coated with a mesoporous silica layer loaded ONC201 as an agonist to specifically target receptor DR5 on ultimately developing Mg‐HAP@MS/ONC201 nanoparticle (MHMO NP) system, engineered. Owing its excellent piezoelectric properties, MHMO facilitates release significant amount reactive oxygen species Ca within effectively promoting upregulation expression inducing necroptosis overcome resistance. Concurrently, released microenvironment promotes CD8 + T activation response antitumor reaction induced ICD. Using RNA‐seq analysis, it elucidated that can activate NF‐κB pathway under catalysis, thus M1‐type macrophage polarization. summary, dual‐targeting therapy system targets both cells catalysis designed. This holds substantial advancements immunotherapy.

Language: Английский

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Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Language: Английский

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Red‐Light Triggered H‐Abstraction Photoinitiators for the Efficient Oxygen‐Independent Therapy of Hypoxic Tumors

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(41)

Published: July 4, 2024

Abstract The clinical application of photodynamic therapy (PDT) is limited by oxygen‐dependence and side effects caused photosensitizer residues. Photoinitiators based on the H‐abstraction reaction can address these challenges because they generate alkyl radical‐killing cells independently oxygen undergo rapid bleaching following H‐abstraction. Nonetheless, development photoinitiators for PDT has been impeded absence effective design strategies. Herein, we have developed aryl‐ketone substituted cyanine (ACy−R), first red‐light triggered hypoxic cancer therapy. These ACy−R molecules inherited near‐infrared absorption dye, modification imparted capability. Experimental quantum calculations revealed that modifying electron‐withdrawing groups aryl (e.g., ACy‐5F) improved contribution O atom to photon excitation process promoting intersystem crossing ability. Particularly, ACy‐5F rapidly penetrated enriched in endoplasmic reticulum. Even under severe hypoxia, initiated induced with intracellular biomolecules, inducing necroptosis ferroptosis. Moreover, was degraded after H‐abstraction, thus avoiding long‐term phototoxicity This study not only provides a crucial molecular tool tumors therapy, but also presents promising strategy multifunctional photosensitizers photoinitiators.

Language: Английский

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Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101661 - 101661

Published: March 1, 2025

Language: Английский

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Single-atom Zr doped heterojunction enhanced piezocatalysis for implant infection therapy through synergistic metal immunotherapy with sonodynamic and physical puncture

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Recent common clinical treatments for implant bacterial infections involve replacing inert implants and using antibiotics. However, these methods remain limited in their effectiveness pathogen clearance, immune regulation, osteogenesis. In this study, we developed a Zr-doped heterointerface of SrTiO3 Hap (SrTiZrO3/Hap) heterojunction coating with single-atom Zr doping heterogeneous interfaces designed ultrasound-responsive antimicrobial activity bone formation. Under ultrasound, the mechanical force exerted by SrTiZrO3/Hap enhances its physical puncture sonodynamic activity, synergizing metalloimmunotherapy effect Zr4+ efficient activity. The primary mechanism enhancing involves local interfacial polarization from doping, achieving piezoelectric catalysis conjunction electronic built-in electric field. achieved 99.3% antibacterial rate against S. aureus 99.7% E. coli under ultrasound. Additionally, promoted osteogenic differentiation after ultrasound irradiation activating PI3K/Akt pathway via piezoelectric, needle-like topological surface release functional ions, thus accelerating repair.

Language: Английский

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Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 3, 2025

Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system doping ytterbium in metal-organic framework (O3P@LPYU), which can be triggered physiological intrapleural pressure during breath. Under gently alterative pressure, nanoparticles with notable peroxidase-like activity effectively produce burst of reactive oxygen species and induce immunogenic cell death catalysis carried ozone as well peroxide interstitial fluid. A clear sustained biodistribution is observed tumors upon administration particle. Remarkably, due to abundant substrates oxygen-rich environment cavity, O3P@LPYU particle provides potent reduction MPE volume durable inhibition growth thorax. Our work not only develops bio-responsive nano-system, but also strategy persistent suppression clinics.

Language: Английский

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Engineered Biomimetic Cancer Cell Membrane Nanosystems Trigger Gas‐Immunometabolic Therapy for Spinal‐Metastasized Tumors

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Despite great progress in enhancing tumor immunogenicity, conventional gas therapy cannot effectively reverse the immunosuppressive microenvironment (TIME), limiting immunotherapy. The development of therapeutic gases that are responsive and efficiently TIME for precisely targeted gas‐immunometabolic remains a challenge. In this study, novel cancer cell membrane‐encapsulated pH‐responsive nitric oxide (NO)‐releasing biomimetic nanosystem (MP@AL) is prepared. Lactate oxidase (Lox) MP@AL consumed oxygen to promote decomposition lactate, metabolic by‐product glycolysis, generation H 2 O , while L‐arginine (L‐Arg) oxidized by generate (NO). For one thing, NO led mitochondrial dysfunction cells reduce consumption efficiency Lox lactate decomposition, thus reversing lactate‐induced TIME; another, triggered immunogenic death, activated anti‐tumor immune response long‐term memory, ensured favorable effect synergistic interaction with PD‐L1 antibody inhibiting growth recurrence. Therefore, dual closed‐loop immunogenicity remodeling established. Overall, work will provide new ideas remodel enhance

Language: Английский

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Revealing the Optimization Route of Piezoelectric Sonosensitizers: From Mechanism to Engineering Methods

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Piezoelectric catalysis is a novel catalytic technology that has developed rapidly in recent years and attracted extensive interest among researchers the field of tumor therapy for its acoustic-sensitizing properties. Nevertheless, are still controversial about key technical difficulties modulation piezoelectric sonosensitizers applications, which undoubtedly major obstacle to performance sonosensitizers. Clarification this challenge will be beneficial design optimization future. Here, authors start from mechanism elaborate methods defect engineering phase based on energy band theory. The combined therapeutic strategy with enzyme immunotherapy introduced. Finally, challenges prospects highlighted. Hopefully, explorations can guide toward applied their own research.

Language: Английский

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Ce₁₂V₆ Clusters with Multi‐Enzymatic Activities for Sepsis Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 11, 2024

Artificial enzymes, especially nanozymes, have attracted wide attention due to their controlled catalytic activity, selectivity, and stability. The rising Cerium-based nanozymes exhibit unique SOD-like Vanadium-based always hold excellent GPx-like activity. However, most inflammatory diseases involve polymerase biocatalytic processes that require multi-enzyme activities. nanocomposite can fulfill multi-enzymatic activity simultaneously, but large nanoparticles (>10 nm) cannot be excreted rapidly, leading biosafety challenges. Herein, atomically precise Ce

Language: Английский

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