Nucleic acid-based wearable and implantable electrochemical sensors

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7960 - 7982

Published: Jan. 1, 2024

This review discusses the advancements, sensor design, and challenges in creating wearable implantable nucleic acid-based sensors for personalized healthcare through real-time biomarker analysis biofluids.

Language: Английский

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Materials Containing Single‐, Di‐, Tri‐, and Multi‐Metal Atoms Bonded to C, N, S, P, B, and O Species as Advanced Catalysts for Energy, Sensor, and Biomedical Applications

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 1, 2024

Abstract Modifying the coordination or local environments of single‐, di‐, tri‐, and multi‐metal atom (SMA/DMA/TMA/MMA)‐based materials is one best strategies for increasing catalytic activities, selectivity, long‐term durability these materials. Advanced sheet supported by metal atom‐based have become a critical topic in fields renewable energy conversion systems, storage devices, sensors, biomedicine owing to maximum utilization efficiency, precisely located centers, specific electron configurations, unique reactivity, precise chemical tunability. Several offer excellent support are attractive applications energy, medical research, such as oxygen reduction, production, hydrogen generation, fuel selective detection, enzymatic reactions. The strong metal–metal metal–carbon with metal–heteroatom (i.e., N, S, P, B, O) bonds stabilize optimize electronic structures atoms due interfacial interactions, yielding activities. These provide models understanding fundamental problems multistep This review summarizes substrate structure‐activity relationship different active sites based on experimental theoretical data. Additionally, new synthesis procedures, physicochemical characterizations, biomedical discussed. Finally, remaining challenges developing efficient SMA/DMA/TMA/MMA‐based presented.

Language: Английский

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Design and Development of Transient Sensing Devices for Healthcare Applications

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 14, 2024

Abstract With the ever‐growing requirements in healthcare sector aimed at personalized diagnostics and treatment, continuous real‐time monitoring of relevant parameters is gaining significant traction. In many applications, health status may be carried out by dedicated wearable or implantable sensing devices only within a defined period followed sensor removal without additional risks for patient. At same time, disposal increasing number conventional portable electronic with short life cycles raises serious environmental concerns due to dangerous accumulation chemical waste. An attractive solution address these complex contradictory demands offered biodegradable devices. Such able perform required tests programmed then disappear safe resorption body harmless degradation environment. This work critically assesses design development concepts related bioresorbable sensors applications. Different aspects are comprehensively addressed, from fundamental material properties principles application‐tailored designs, fabrication techniques, device implementations. The emerging approaches spanning last 5 years emphasized broad insight into most important challenges future perspectives provided.

Language: Английский

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3D‐Printed Polymeric Biomaterials for Health Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract 3D printing, also known as additive manufacturing, holds immense potential for rapid prototyping and customized production of functional health‐related devices. With advancements in polymer chemistry biomedical engineering, polymeric biomaterials have become integral to 3D‐printed applications. However, there still exists a bottleneck the compatibility with different printing methods, well intrinsic challenges such limited resolution rates. Therefore, this review aims introduce current state‐of‐the‐art It begins an overview landscape techniques, followed by examination commonly used biomaterials. Subsequently, examples devices are provided classified into categories biosensors, bioactuators, soft robotics, energy storage systems, self‐powered devices, data science bioplotting. The emphasis is on exploring capabilities manufacturing desired geometries that facilitate device functionality studying reasons material choice. Finally, outlook possible improvements near future presented, projecting contribution general field healthcare.

Language: Английский

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Fabrication and Investigation on Mechanical, Electrical, and Sensing Performance of Polydimethylsiloxane/Carbon Nanotube and Thermoplastic Polyurethane/Carbon Nanotube Wearable Strain Sensors

Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Recent interest in stretchable electronics and wearable technology has driven the demand for flexible strain sensors. Conductive polymer composites have gained increasing attention as sensors owing to their potential advantages. In this study, effect of different matrices varying carbon nanotube (CNT) loadings by fabricating sandwich‐structured polydimethylsiloxane (PDMS)/CNT thermoplastic polyurethane (TPU)/CNT is investigated using a solution mixing process. The uniform dispersion CNTs both PDMS/CNT TPU/CNT nanocomposites facilitates proper electrical conductivity. PDMS/CNT6% TPU/CNT6% demonstrate higher linear performance under monotonic strains up 20% compared other samples. cyclic stress–strain tests, perform more efficiently an immediate response sensors, which exhibit shoulder peak phenomenon. This phenomenon occurs due mechanical properties hysteresis TPU matrices. these findings, it revealed that relative standard deviation % (RSD%) values are smaller than TPU/CNT, confirms considerable repeatability Furthermore, offers effective detection human body motion, such finger joint movements with bending angles wrist at various rates. present guideline provided material selection

Language: Английский

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Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Uncontrolled degradation of wound dressings may result in residues, causing several negative effects on healing, such as secondary damage, undesirable inflammation, and scar skin formation. Here, an available strategy associated with the synthesis enzyme-loaded (Burkholderia cepacia lipase, BCL) polycaprolactone (PCL) nanofiber scaffolds, aligning healing is reported. These scaffolds are fabricated via fiber microfluidic electrospinning degradation-control technique. The obtained exhibit tunable rates, achieving complete within 12-72-h cycles. acidic products further elucidated reveal potential mechanism. create optimal microenvironment during hemostasis inflammation stages healing. Notably, vivo experiments demonstrate effectively promote angiogenesis, reduce inflammatory responses, mitigate collagen deposition, regulate fibroblast differentiation. This promotes rapid a remarkable scarless rate over 99% by day 21. New guidelines for scar-free proposed, which carry out faster without microplastics (MPs) toxic byproducts before principles might provide valuable insights promise developing more effective dressings.

Language: Английский

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Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Transient technology involves materials and devices that undergo controlled degradation after a reliable operation period. This groundbreaking strategy offers significant advantages over conventional based on non‐renewable by limiting environmental exposure to potentially hazardous components disposal, increasing material circularity. As the most abundant naturally occurring polymer Earth, cellulose is an attractive for this purpose. Besides, (nano)celluloses are inherently biodegradable have competitive mechanical, optical, thermal, ionic conductivity properties can be exploited develop sustainable avoid end‐of‐life issues associated with systems. Despite its potential, few efforts been made review current advances in cellulose‐based transient technology. Therefore, catalogs state‐of‐the‐art developments enabled cellulosic materials. To provide wide perspective, various mechanisms involved introduced. The advanced capabilities of systems sensing, photonics, energy storage, electronics, biomedicine also highlighted. Current bottlenecks toward successful implementation discussed, circularity impact metrics at center. It believed will serve as valuable resource proliferation into fully integrated, circular, environmentally devices.

Language: Английский

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Transient Implantable Electronics for Postsurgery Preventive Medicine

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract The field of postoperative care has seen a remarkable shift toward the utilization electronic implantable devices, including sensors, biosensors, stimulators, and drug delivery systems, all designed with biodegradable form factor wireless data/power transmission capability. These technologies hold immense potential for postsurgery out‐of‐hospital monitoring during postdischarged period, where continuous physiological signals is lacking. Furthermore, these devices eliminate need secondary surgeries required device retrieval as they can safely degraded in body, thus enhancing patient recovery. This review delves into latest advancements examining their application vital signs, innovative communication powering employ, materials that enable function. analysis extends to evaluating efficacy limitations across various medical applications. Moreover, it explores future research directions, emphasizing material advancements, miniaturization, customization, integration artificial intelligence create closed‐loop therapeutic systems. comprehensive underscores transformative outlines pathway innovations this dynamic field.

Language: Английский

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Piezoelectric Behaviour in Biodegradable Carrageenan and Iron (III) Oxide Based Sensor

Sensors, Journal Year: 2024, Volume and Issue: 24(14), P. 4622 - 4622

Published: July 17, 2024

This paper is dedicated to the research of phenomena noticed during tests biodegradable carrageenan-based force and pressure sensors. Peculiar voltage characteristics were impact tests. Therefore, sensors' responses researched more thoroughly, defining time-dependent sensor output signals from calibrated energy impact. The was performed using experimental methods when a free-falling steel ball impacted material create relatively definable energy. sensor's signal, which analogue voltage, registered an oscilloscope transmitted PC for further analysis. obtained results showed very interesting outcome, where sensor, intended be piezoresistive, demonstrated combination behaviour typical galvanic cells piezoelectric material. It provides stable DC that sensitive applied statical pressure, in case sudden impact, like hit, it demonstrates with some particular effects, are described as proton transfer sensor-sensitive Such design matter development research.

Language: Английский

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