Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133942 - 133942

Published: July 16, 2024

Language: Английский

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Navigating the crossroads of cell death interplay and intersections among ferroptosis, apoptosis and autophagy

Drug Metabolism and Personalized Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract The review article, “Navigating the Crossroads of Cell Death: Interplay and Intersections Among Ferroptosis, Apoptosis, Autophagy,” delves into complex interactions between these three key cell death pathways. Understanding how ferroptosis, apoptosis, autophagy intersect is crucial for maintaining cellular homeostasis. Each pathway represents a unique mechanism death, recent research highlights their intricate interconnections mutual influences. Exploring relationships vital comprehending cells make fate decisions processes are implicated in various diseases. review’s significance lies elucidating molecular details providing insight balance survival death. interplay among has important implications developing therapeutic interventions, particularly diseases where regulation disrupted. By examining crosstalk pathways, researchers can identify new drug targets devise strategies to modulate effectively. This aims enhance our understanding biology by offering detailed perspective on dynamic interconnected nature mechanisms.

Language: Английский

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Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor‐Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug‐Resistant Tumors

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Breast cancer is a malignant tumor that threatens the life and health of women worldwide. As first-line chemotherapy drug for breast cancer, doxorubicin (DOX) can inhibit synthesis RNA DNA, it exhibits strong inhibitory activity against cancer. However, drug-induced systemic toxicity resistance occur with DOX treatment. In this work, TSPO protein identified as promising target overcoming we designed novel BT-DOX/PDP conjugate to solve these problems in chemotherapy. It found effectively downregulate TSPO1 sensitize MCF-7/Adr DOX. Furthermore, due its positive charge, readily loaded into puerarin (PUE), resulting BT-DOX/PDP@PUE exhibited minimal but enhanced antitumor animal models, compared BT-DOX/PDP. This study demonstrates advantages combined photodynamic therapy resistance, which may be applied design other therapy-based conjugates enhance therapy.

Language: Английский

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Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: July 3, 2024

The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human health. Although more and researches have confirmed the ZnO NPs, limited attention has been given to impact early embryonic nervous system. This study aimed explore exposure NPs neurogenesis its underlying mechanisms. We conducted experiments here confirm hypothesis that causes neural tube defects in development. first used mouse chicken embryos Zn

Language: Английский

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Koji Mold-derived Lipids Disrupt the Intracellular Redox State by Decreasing the GPx4 and Intracellular Glutathione Levels, Promoting Membrane Lipid Peroxidation, and Inducing Ferroptosis in HL-60 Cells

Journal of Oleo Science, Journal Year: 2024, Volume and Issue: 73(7), P. 991 - 999

Published: Jan. 1, 2024

In this study, we evaluated the cancer cell killing activity of koji mold-derived extracts using several solvents. The mold lipid extract (KML) exhibited potent cytotoxicity against a human leukemia line. Fractionation KML via silica gel chromatography revealed presence active components in fraction (Fr.) 6. Cytotoxic effects Fr. 6 were inhibited by ferroptosis inhibitors, ferrostatin-1 and SRS11-92, iron chelator, deferoxamine. Interestingly, inhibitors failed to prevent KML-induced death. decreased expression glutathione peroxidase 4 (GPx4) increased level peroxidized plasma membrane lipids. Furthermore, intracellular levels. Overall, our results suggest that included induces HL-60 cells.

Language: Английский

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Computational pipeline predicting cell death suppressors as targets for cancer therapy

iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110859 - 110859

Published: Aug. 30, 2024

Identification of promising targets for cancer therapy is a global effort in precision medicine. Here, we describe computational pipeline integrating transcriptomic and vulnerability responses to cell-death inducing drugs, predict suppressors as candidate therapy. The prediction based on two modules; the similarity module identify genes whose targeting results similar death-inducing correlation expression correlates cells same death-inducers. combined predictors these modules were integrated into single metric. As proof-of-concept, selected ferroptosis inducers drugs triple negative breast cancer. reliably predicted suppressors, validated by methods cellular assays. described might be used repressors various pathways potential therapeutic different types.

Language: Английский

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Pharmacologically Targeting Ferroptosis and Cuproptosis in Neuroblastoma

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

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A Recent Overview of Molecular Pathways in Synthetic Lethality as a Proposed Valid Target in Oncology: Current Insights and Future Directions

Indian Journal of Surgical Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Language: Английский

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