Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury DOI Creative Commons
Zeping Liu,

Chunyu Xiang,

Xu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below level or permanent loss function in severe cases. Dynamic spatiotemporal neuroinflammation vital neurological recovery, which collectively constituted by dynamic changes series inflammatory cells, including microglia, neutrophils, astrocytes, among others. Immunomodulatory nanomaterials readily improve therapeutic effects simultaneously overcome various drawbacks associated with treatment, such as off-target side bioactivity immune agents during circulation. In this review, we discuss role inflammation secondary injuries after SCI, elaborate on mechanism action effect existing treating summarize mechanism(s) whereby they regulate inflammation. Finally, challenges prospects using nanotechnology modulate immunotherapy are discussed provide new insights for future treatment. Deciphering intricate mechanisms SCI requires further in-depth studies. Therefore, continues represent formidable challenge.

Language: Английский

Targeted Repair of Spinal Cord Injury Based on miRNA‐124‐3p–Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus Glycoprotein DOI Creative Commons

Xiangchuang Fan,

Lusen Shi,

Zimeng Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(21)

Published: March 21, 2024

Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spinal barrier (BSCB). To address these challenges, new nano complex that achieves targeted damaged spinal is proposed, which contains mesoporous silica nanoparticle core loaded with microRNA cloaking layer human umbilical mesenchymal stem cell membrane modified rabies virus glycoprotein (RVG). The more readily crosses BSCB exosome-resembling properties, including appropriate size low-immunogenic disguise accumulates in center because RVG, where it releases abundant microRNAs elicit sprouting rehabilitate inflammatory microenvironment. Culturing complexes promotes axonal growth neurons M2 polarization microglia. Furthermore, showed SCI mice treated this by tail vein injection display improvement regrowth, microenvironment regulation, functional restoration. efficacy biocompatibility demonstrate their immense potential as noninvasive for SCI.

Language: Английский

Citations

9
Neuronal Dual-Specificity Phosphatase 26 Inhibition via Reactive-Oxygen-Species Responsive Mesoporous-Silica-Loaded Hydrogel for Spinal Cord Injury Repair DOI
Kai Zhang,

Runlin Wen,

Wanrong Ma

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals most spinal neurons results an inability to reestablish neural circuits. In this study, we found that with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, expression dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably undergoing spontaneous regeneration. Therefore, developed system named F10@MS@UV-HG integrated DUSP26-specific inhibitor into reactive oxygen species-responsive nanoparticles and embedded them photosensitive hydrogels. This effectively downregulated DUSP26 primary enhanced phosphorylation, ultimately promoting outgrowth. When transplanted mouse model, achieved sustained drug release, specifically targeting DUSP26/ERK/ELK1 pathway facilitating short-term Additionally, long-term repair effects─including improved myelination motor function─were evident mice F10@MS@UV-HG. The suggested activating signaling by modulating could promote functional recovery. Thus, exhibits enormous potential therapeutic approach for patients SCI.

Language: Английский

Citations

0
Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles DOI Creative Commons
Jingqi Li, Zhaoyu Wang,

Yongchun Wei

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: 3(3), P. 137 - 168

Published: Feb. 2, 2025

Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are nanoscale lipid bilayer secreted by mesenchymal stem cells. They inherit the parent cell's attributes, facilitating tissue repair and regeneration, promoting angiogenesis, modulating immune response, while offering advantages like reduced immunogenicity, straightforward administration, enhanced stability for long-term storage. These characteristics elevate MSC-EVs as highly promising in cell-free therapy with notable clinical potential. It is critical to delve into their pharmacokinetics thoroughly elucidate intracellular vivo trajectories. A detailed summary evaluation of existing tracing strategies needed establish standardized protocols. Here, we have summarized anticipated research progress various biomedical imaging techniques, including fluorescence imaging, bioluminescence nuclear (PET, SPECT), tomographic (CT, MRI), photoacoustic imaging. The challenges prospects MSC-EV strategies, particular emphasis on translation, been analyzed, solutions proposed.

Language: Английский

Citations

0
The therapeutic potential of microRNAs to ameliorate spinal cord injury by regulating oligodendrocyte progenitor cells and remyelination DOI Creative Commons

Shanru Qiu,

Hui Dai, Yu Wang

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 15, 2024

Spinal cord injury (SCI) can cause loss of sensory and motor function below the level injury, posing a serious threat to human health quality life. One significant characteristic feature pathological changes following in nervous system is demyelination, which partially contributes long-term deficits neural after injury. The remyelination central (CNS) mainly mediated by oligodendrocyte progenitor cells (OPCs). Numerous complex intracellular signaling transcriptional factors regulate differentiation process from OPCs mature oligodendrocytes (OLs) myelination. Studies have shown importance microRNA (miRNA) regulating OPC functions. In this review, we focus on demyelination SCI, summarize progress miRNAs functions remyelination, might provide potential therapeutic target for SCI treatments.

Language: Английский

Citations

2
Current multi-scale biomaterials for tissue regeneration following spinal cord injury DOI

Y Zhang,

Zhonghuan Wu,

Junfeng Wu

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: 178, P. 105801 - 105801

Published: July 5, 2024

Language: Английский

Citations

2
Research Progress on Treating Spinal Cord Injury by Modulating the Phenotype of Microglia DOI Creative Commons

Qinghe Yu,

Ziming Cai, Xiaofeng Liu

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(9)

Published: Sept. 19, 2024

Spinal cord injury (SCI) is a severe central nervous system disorder with no currently available effective treatment. Microglia are immune cells in the that play crucial roles SCI occurrence, development, and recovery stages. They exhibit dynamic polarization over time can switch between classical activation (M1) alternative (M2) phenotypes to respond environmental stimuli. The M1 phenotype involved initiating sustaining inflammatory responses, while M2 exerts anti-inflammatory effects promotes tissue repair damaged areas. Inhibiting promoting have become hotspots regulating neuroinflammation treating SCI. This article provides comprehensive review centered on modulating microglial for

Language: Английский

Citations

2
Nanoplatelets modified with RVG for targeted delivery of miR-375 and temozolomide to enhance gliomas therapy DOI Creative Commons
Tingting Yang, Nan Zhang, Yuanyuan Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 15, 2024

Gliomas are one of the most frequent primary brain tumors and pose a serious threat to people's lives health. Platelets, crucial component blood, have been applied as drug delivery carriers for disease diagnosis treatment. In this study, we designed engineered nanoplatelets targeted therapeutic miR-375 temozolomide (TMZ, first-line glioma treatment agent) enhance therapy. Nanoplatelets were prepared through mild ultrasound, TMZ co-loaded ultrasound electrostatic interactions, respectively, combine chemotherapy with gene therapy against glioma. To improve blood barrier (BBB) crossing efficiency targeting ability, modified central nervous system-specific rabies viral glycoprotein peptide (RVG) thiol-maleimide click reaction. The RVG (NR/TMZ/miR-375) not only inherited good stability remarkable biocompatibility platelets, but also promoted cellular uptake penetration tissues, effectively induced cell apoptosis effect drugs. vivo studies showed that NR/TMZ/miR-375 significantly increased circulation time TMZ, exhibited superior combined antitumor effects. summary, multifunctional 'natural' nanodrug system provides potent, scalable, safety approach platelet-based cancer

Language: Английский

Citations

2
hUCMSC-derived exosomes mitigate blood-spinal cord barrier disruption by activating AMPK/mTOR-mediated autophagic flux after acute spinal cord injury DOI

Zhiheng Chen,

Shengting Wu,

S. Sheng

et al.

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 289, P. 111944 - 111944

Published: Nov. 5, 2024

Language: Английский

Citations

1
Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury DOI Creative Commons
Zeping Liu,

Chunyu Xiang,

Xu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below level or permanent loss function in severe cases. Dynamic spatiotemporal neuroinflammation vital neurological recovery, which collectively constituted by dynamic changes series inflammatory cells, including microglia, neutrophils, astrocytes, among others. Immunomodulatory nanomaterials readily improve therapeutic effects simultaneously overcome various drawbacks associated with treatment, such as off-target side bioactivity immune agents during circulation. In this review, we discuss role inflammation secondary injuries after SCI, elaborate on mechanism action effect existing treating summarize mechanism(s) whereby they regulate inflammation. Finally, challenges prospects using nanotechnology modulate immunotherapy are discussed provide new insights for future treatment. Deciphering intricate mechanisms SCI requires further in-depth studies. Therefore, continues represent formidable challenge.

Language: Английский

Citations

0