Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

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Reactive Microneedle Patches with Antibacterial and Dead Bacteria‐Trapping Abilities for Skin Infection Treatment

Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)

Published: April 6, 2024

Abstract Bacterial skin infections are highly prevalent and pose a significant public health threat. Current strategies primarily focused on the inhibition of bacterial activation while disregarding excessive inflammation induced by dead bacteria remaining in body effect acidic microenvironment during therapy. In this study, novel dual‐functional MgB 2 microparticles integrated microneedle (MgB MN) patch is presented to kill eliminate for infection management. The not only can produce local alkaline promote proliferation migration fibroblasts keratinocytes, but also achieve >5 log inactivation. Besides, effectively mitigate bacteria‐induced through interaction with lipopolysaccharide (LPS). With incorporation these microparticles, resultant MN patches capture bacteria, thereby mitigating inflammation. Therefore, show good therapeutic efficacy managing animal infections, including abscesses wounds. These results indicate that reactive metal borides‐integrated hold great promise treatment clinical infections.

Language: Английский

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Microneedle-Based Approaches for Skin Disease Treatment

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 6, 2025

Abstract The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints conventional methods by their superior safety and efficacy through precise targeting, while simultaneously enabling painless delivery. Currently, are increasingly used carriers delivery, with loading insoluble drugs to improve treatment efficiency or combining bioactive substances construction efficient system maximize effects substances. preparation diverse, them meet requirements most applications. emergence addressed shortcomings associated drugs, expanded applications substances, improved in clinical practice. This review summarizes current information on application a variety such psoriasis, vitiligo, alopecia, hypertrophic scarring, atopic dermatitis, melanoma, acne, infections. future opportunities diseases also discussed. Despite substantial progress vectors, issues low poor mechanical strength during remain main challenges. Therefore, implementation MNs-based therapies remains limited, highlighting key research.

Language: Английский

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Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk infection and excessive reactive oxygen species (ROS) during early stage, residual bacteria delayed Osseo integrated interface later which jointly creates complex dynamic microenvironment leads non‐union. The melatonin carbon dots (MCDs) possess antibacterial osteogenesis abilities, greatly simplifying composition multifunctional material. Therefore, hydrogel containing MCDs (GH‐MCD) is developed meet multi‐stage repair needs injury this study. GH‐MCD can intelligently release responding acidic scavenge intracellular ROS exhibit good activity by inducing production inhibiting expression secA2 . Moreover, it has long‐lasting antimicrobial repair. RNA‐seq results reveal that hydrogels promote infected healing enhancing cellular resistance bacteria, balancing osteoclastogenesis, regulating immune microenvironment. In conclusion, through programmed transformation microenvironment, providing novel strategy for defects.

Language: Английский

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Multifunctional Boron‐based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Effective management of serious respiratory diseases, such as asthma and recalcitrant rhinitis, remains a global challenge. Here, it is shown that induced sputum supernatants (ISS) from patients with contain higher levels cell-free DNA (cfDNA) compared to healthy volunteers. Although cfDNA scavenging strategies have been developed for inflammation modulation in previous studies, this fall short clinical settings due the excessive neutrophil extracellular trap (NET) formation, reactive oxygen nitrogen species (RONS) bacterial infections injured airway tissues. Based on this, multifunctional boron-based 2D nanoplatform B-PM designed by coating boron nanosheets (B-NS) polyamidoamine generation 1 (PG1) dendrimer, which can simultaneously target cfDNA, NETs, RONS, bacteria. The effects promoting mucosal repair, reducing inflammation, mucus production demonstrated model mice, therapeutic effect superior dexamethasone. Furthermore, flow cytometry clustering analysis transcriptome RNA-sequencing are adopted comprehensively evaluate vivo anti-inflammation effects. These findings emphasize significance multi-targeting strategy modulate dysregulated highlight nanoplatforms amelioration inflammatory diseases.

Language: Английский

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Au Nanorods Activate Zn²⁺/Ag⁺ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(10), P. 4791 - 4800

Published: Sept. 24, 2024

Language: Английский

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Engineered Microneedle System Enables the Smart Regulation of Nanodynamic Sterilization and Tissue Regeneration for Wound Management

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract The healing of bacterial biofilm‐infected wounds is a complex process, and the construction emerging therapeutic modalities that regulate microenvironment to magnify effects reduce biotoxicity still highly challenging. Herein, an engineered microneedle (MN) patch reported mediate efficient delivery black phosphorus nanosheets (BP NSs) copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization methicillin‐resistant staphylococcus aureus (MRSA)‐infected wound healing. Results demonstrate system can eliminate biofilm, cytotoxicity, promote angiogenesis tissue regeneration by multiple advantages chemodynamic therapy (CDT), enhanced photodynamic (PDT), improved degradation process from BP NSs phosphate promoting cell proliferation. Notably, balance between excellent stability rapid degradability maintained, mechanism vividly elucidated density functional theory (DFT)‐based molecular dynamics (MD) calculations. Furthermore, transcriptional changes treated MRSA‐infected skin are studied using RNA‐seq technology reveal potential mechanism. As envisaged, proposed MN provides safe, easy, also effective approach achieve temporal regulation wounds.

Language: Английский

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Lignin-based nanoenzyme doped hydrogel for NO-enhanced chemodynamic therapy of bacterial infections

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140489 - 140489

Published: Jan. 29, 2025

Language: Английский

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Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101539 - 101539

Published: Feb. 1, 2025

The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack intrinsic bioactivities orchestrate intricate regenerative process. To tackle this deficiency, nature-derived microneedles (NMs) composed silk methacrylate and snail mucus developed study. resultant NMs have excellent mechanical strength biological adhesiveness, ensuring suture-free but reliable fixation on implanted site. enhance bioactivities, metal-polyphenolic networks (MPNs) coordinated from copper (Cu) curcumin (Cur) designed encapsulated into NMs. Cu-Cur MPNs harness anti-oxidative anti-inflammatory properties Cur with pro-angiogenic Cu, targeting different negative aspects CSTDs repair. Furthermore, pH-responsive disassembly can respond acidic microenvironment, allowing burst-free on-demand drug delivery. Both in-vitro in-vivo experiments demonstrate that encapsulation (Cu-Cur-NMs) restore redox homeostasis, reduce inflammatory response, promote blood vessel formation, thus remodeling microenvironment greatly improve repair quality CSTDs. Therefore, combined advantages microneedles-based patch system MPNs-based nanotherapeutic agent explored first time, our proposed Cu-Cur-NMs represent a multifunctional promising device

Language: Английский

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Dissolving Microneedles as In Situ Chemical Reaction Chambers: from Design Strategies to Versatile Biomedical Applications

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.

Language: Английский

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