IL‐12p70 Induces Neuroprotection via the PI3K‐AKT‐BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction DOI
Tingting Huang, Jie Hong, Ling Jia

et al.

Advanced Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Postoperative cognitive dysfunction (POCD), a postsurgical decline in function, primarily affects older adults and worsens their prognosis. Although elevated interleukin‐12p70 (IL‐12p70) is closely correlated with slower adults, its role POCD remains unclear. Here, IL‐12p70 identified as significant mediator of therapeutic effect electroacupuncture (EA) on POCD. EA at acupoints ST36, GV20, GV24 significantly enhanced behaviors mice. IL‐12p70, downregulated mice but rescued by treatment, the cytokine associated EA's effect. Clinically, adults’ serum post‐surgery. Furthermore, exerts potent neuroprotective both neuronal cell lines primary hippocampal neurons. The PI3K‐AKT‐BCL2 axis enriched silico analysis validated signaling mechanism underlying IL‐12p70‐induced neuroprotection. In vivo, beneficial effects treatment activation are reproduced administration attenuated knockdown. findings reveal novel POCD, demonstrating that activating newly‐discovered function highlight potential treating disorders.

Language: Английский

Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice DOI Creative Commons
Liu Yang, Yanyu Zhou,

Zhaoshuai Huang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)

Published: June 25, 2024

Abstract Lack of liver regenerative capacity is the primary cause hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance regeneration pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on following partial thereby substantiating role played by vagus nerve process regeneration. In recent years, electroacupuncture (EA) has emerged as a non‐invasive technique stimulating nerve. However, EA remains uncertain. this study, 70% hepatectomy (PH) mouse model utilized investigate effects acute elucidate its underlying molecular mechanisms. It observed at ST36 acutely activated cholinergic neurons dorsal motor nucleus (DMV), resulting increased release acetylcholine from vagal endings subsequent activation IL‐6 signaling macrophages. Ultimately, these events promoted hepatocyte proliferation facilitated These findings provide insights into fundamental brain‐liver axis mechanism through which promotes regeneration, offering novel therapeutic approach post‐hepatectomy disorders.

Language: Английский

Citations

5
Mapping the knowledge domains of literature on hepatocellular carcinoma and liver failure: a bibliometric approach DOI Creative Commons
Jun Pu,

Zhao Ya-min,

Siming Zhang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 16, 2025

Hepatocellular carcinoma (HCC) accounts for 75-85% of primary liver cancers, with its incidence continually rising, posing a threat to socio-economic development. Currently, resection is the standard treatment HCC. However, post-hepatectomy failure (PHLF) severe and formidable postoperative complication that increases patients' medical expenses mortality risk. Additionally, can occur at any stage HCC development, severely affecting quality life prognosis. Using Web Science Core Collection, this bibliometric study analyzed English articles reviews on from 2003 2023. Bibliometric tools like CiteSpace, VOSviewer, R-studio were employed data visualization analysis, focusing publication trends, citation metrics, explosive intensity, collaborative networks. Use Comparative Toxicogenomics Genecards databases screen genes related failure, perform enrichment analyses using Gene Ontology, Kyoto Encyclopedia Genes Genomes, PubMed identified differentially expressed genes. The significant increase in publications key contributions journals such as World Journal Gastroenterology Hepatology. United States, China, Japan leading countries research output. Prominent authors institutions, including Kudo Masatoshi Sun Yat-sen University, identified. Enrichment analysis showed drug metabolism, oxidative stress, lipid other pathways are closely field. Research hotspots included risk prediction models novel therapies. This highlights growing interest advancements failure. Future should focus improving prediction, developing new therapies, enhancing international collaboration address these critical health issues.

Language: Английский

Citations

0
Fluorinated Sulfonamide-Flavonoid Derivatives as Novel Keap1-Nrf2 Inhibitors: Potent Induction of Cytoprotective Gene HO-1 In Vivo DOI

Ya-Li Sang,

Weifang Huang, Jiacheng Lin

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 291, P. 117650 - 117650

Published: April 17, 2025

Language: Английский

Citations

0
Electroacupuncture in liver regeneration: a Chinese traditional medicine approach to enhancing liver regeneration DOI

Shangze Jiang,

Yanan Wang

HepatoBiliary Surgery and Nutrition, Journal Year: 2024, Volume and Issue: 13(5), P. 891 - 893

Published: Sept. 27, 2024

Language: Английский

Citations

0
IL‐12p70 Induces Neuroprotection via the PI3K‐AKT‐BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction DOI
Tingting Huang, Jie Hong, Ling Jia

et al.

Advanced Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Postoperative cognitive dysfunction (POCD), a postsurgical decline in function, primarily affects older adults and worsens their prognosis. Although elevated interleukin‐12p70 (IL‐12p70) is closely correlated with slower adults, its role POCD remains unclear. Here, IL‐12p70 identified as significant mediator of therapeutic effect electroacupuncture (EA) on POCD. EA at acupoints ST36, GV20, GV24 significantly enhanced behaviors mice. IL‐12p70, downregulated mice but rescued by treatment, the cytokine associated EA's effect. Clinically, adults’ serum post‐surgery. Furthermore, exerts potent neuroprotective both neuronal cell lines primary hippocampal neurons. The PI3K‐AKT‐BCL2 axis enriched silico analysis validated signaling mechanism underlying IL‐12p70‐induced neuroprotection. In vivo, beneficial effects treatment activation are reproduced administration attenuated knockdown. findings reveal novel POCD, demonstrating that activating newly‐discovered function highlight potential treating disorders.

Language: Английский

Citations

0