Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Spherical
nucleic
acids
(SNAs)
usually
suffer
from
an
undesired
protein
corona
and
disrupt
the
function
of
(e.g.,
aptamer),
thereby
compromising
recognition
response
to
proteins
in
biological
environment.
To
overcome
unexpected
interference,
specific
were
initially
adsorbed
onto
magnetic
particles
(MPs)
as
a
customized
"shield"
with
fabricated
acid
scaffolds,
forming
preadsorbed
particle-based
spherical
(pap-SNA).
By
comparing
AuNPs-SNA
or
COOH-MPs,
it
was
found
that
such
pap-SNA
significantly
eliminated
adsorption
nonspecific
other
biomolecules
MPs'
interface,
enabling
SNA
directly
respond
complex
matrices.
further
reduce
interference
on
performance,
series
scaffolds
(Z-type,
dsDNA
type,
circle
T-type,
cross-shaped
type)
designed
by
changing
rigidity
thermal
stability
functional
MPs.
As
consequence,
scaffold
improved
sensitivity
pap-SNA-based
detection
platform
orderly
arrangement
provides
steric
hindrance
interferents.
Moreover,
presence
not
only
enables
exhibit
proportional
varied
concentrations
but
also
enhances
160%
serum
190%
urine.
Therefore,
incorporating
optimized
DNA
maintained
facilitated
probe
(aptamer)
surface
SNA.
This
approach
offers
pathway
for
creating
direct
anti-interference
capability
applicable
detecting
diverse
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
This
review
describes
the
formation
of
a
protein
corona
(or
its
absence)
on
different
classes
nanoparticles,
basic
principles,
and
consequences
for
nanomedicine.
For
this
purpose,
it
general
concepts
to
control
(guide/minimize)
interaction
between
artificial
nanoparticles
plasma
proteins
reduce
formation.
Thereafter,
methods
qualitative
or
quantitative
determination
are
presented,
as
well
properties
nanoparticle
surfaces,
which
relevant
prevention
formation).
Thereby
especially
role
grafting
density
hydrophilic
polymers
surface
is
discussed
prevent
corona.
In
context
also
potential
detergents
(surfactants)
temporary
modification
grafting-to
grafting-from
approaches
permanent
discussed.
The
concludes
by
highlighting
several
promising
avenues.
includes
(i)
use
without
active
targeting,
(ii)
synthetic
address
immune
system,
(iii)
recollection
with
defined
after
in
vivo
application
sample
blood
proteome
(iv)
further
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 512 - 512
Published: Feb. 5, 2025
The
rapid
development
of
nanotechnology
provides
new
approaches
to
manufacturing
food-related
nanoparticles
in
various
food
industries,
including
formulation,
functional
foods,
packaging,
and
quality
control.
Once
ingested,
will
immediately
adsorb
proteins
the
biological
fluids,
forming
a
corona
around
them.
Protein
coronas
alter
properties
nanoparticles,
their
toxicity,
cellular
uptake,
targeting
characteristics,
by
altering
aggregation
state.
In
addition,
conformation
function
enzymes
are
also
influenced
formation
protein
coronas,
affecting
digestion
products.
Since
inevitable
application
industries
subsequent
digestion,
comprehensive
understanding
is
essential.
This
systematic
review
introduces
explains
with
interactions
between
nanoparticles.
Furthermore,
potential
origin
that
migrate
from
packaging
materials
fates
gastrointestinal
tract
has
been
reviewed.
Finally,
this
explores
possible
effects
on
bioactive
compounds,
probiotics
prebiotics.
Understanding
mechanisms
crucial,
as
it
enables
design
tailored
delivery
systems
optimize
bioavailability
compounds.
Frontiers in Nanotechnology,
Journal Year:
2025,
Volume and Issue:
7
Published: March 18, 2025
When
nano-sized
objects
are
introduced
into
biological
systems
they
almost
inevitably
will
be
exposed
to
a
compositionally
complex
fluid
environment.
It
is
general
observation
that
nanoparticles
in
such
environments
rapidly
get
covered
by
biomolecular
corona
composed
of
proteins,
lipids,
and
sugars
adsorb
the
particle
surface.
While
this
phenomenon
has
been
extensively
studied
from
an
experimental
point
view,
some
extent
also
theoretically
computationally,
we
still
lack
solid
theoretical
framework.
Here
investigate
kinetics
formation,
particle-to-particle
variability
composition,
spatial
vicinity
different
biomolecules
corona.
We
do
so
under
assumptions
adsorption
occurs
randomly,
irreversible,
there
no
biomolecule-biomolecule
interactions.
derive
analytical
formulae
but
illustrate
their
outcomes
using
for
experiments
reasonable
parameters.
Overall,
our
results,
derived
simplifying
assumptions,
intended
as
useful
reference
points
against
which
both
more
realistic
computational
studies
can
compared.
