Abstract
Large
defects
in
bone
tissue
due
to
trauma,
tumors,
or
developmental
abnormalities
usually
require
surgical
treatment
for
repair.
Numerous
studies
have
shown
that
current
repair
and
regeneration
treatments
certain
complications
limitations.
With
the
in-depth
understanding
of
mechanisms
biological
materials,
a
variety
materials
with
desirable
physicochemical
properties
functions
emerged
field
recent
years.
Among
them,
hydrogels
been
widely
used
research
their
biocompatibility,
unique
swelling
properties,
ease
fabrication.
In
this
paper,
development
classification
were
introduced,
mechanism
promoting
was
described
detail,
including
promotion
marrow
mesenchymal
stem
cell
differentiation,
angiogenesis,
enhancement
activity
morphogenetic
proteins,
regulation
microenvironment
tissues.
addition,
future
direction
hydrogel
engineering
discussed.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 14, 2024
Abstract
This
review
highlights
recent
advancements
in
the
synthesis,
processing,
properties,
and
applications
of
2D‐material
integrated
hydrogels,
with
a
focus
on
their
performance
bone‐related
applications.
Various
synthesis
methods
types
2D
nanomaterials,
including
graphene,
graphene
oxide,
transition
metal
dichalcogenides,
black
phosphorus,
MXene
are
discussed,
along
strategies
for
incorporation
into
hydrogel
matrices.
These
composite
hydrogels
exhibit
tunable
mechanical
high
surface
area,
strong
near‐infrared
(NIR)
photon
absorption
controlled
release
capabilities,
making
them
suitable
range
regeneration
therapeutic
In
cancer
therapy,
2D‐material‐based
show
promise
photothermal
photodynamic
therapies,
drug
delivery
(chemotherapy).
The
properties
these
materials
enable
selective
tumor
ablation
upon
NIR
irradiation,
while
drug‐loading
capacity
facilitates
targeted
chemotherapeutic
agents.
Additionally,
2D‐materials
‐infused
potent
antibacterial
activity,
effective
against
multidrug‐resistant
infections
disruption
biofilm
generated
implant
surface.
Moreover,
synergistic
therapy
approach
combines
multiple
treatment
modalities
such
as
photothermal,
chemo,
immunotherapy
to
enhance
outcomes.
bio‐imaging,
serve
versatile
contrast
agents
imaging
probes,
enabling
real‐time
monitoring
during
imaging.
Furthermore,
bone
regeneration,
most
incorporated
promote
osteogenesis
tissue
offering
potential
solutions
defects
repair.
Overall,
integration
presents
promising
platform
developing
multifunctional
theragenerative
biomaterials.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Antimicrobial
resistance
and
impaired
bone
regeneration
are
the
great
challenges
in
treating
infected
defects.
Its
recurrent
resistant
nature,
high
incidence
rate,
long‐term
hospitalization,
medical
costs
have
driven
efforts
of
scientific
community
to
develop
new
therapies
improve
situation.
Considering
complex
microenvironment
persistent
mechanisms
mediated
by
bacteria,
it
is
crucial
an
implant
with
enhanced
osseointegration
sustained
effective
infection
clearance
effects.
Here,
a
positively
charged
quaternized
chitosan
(QCS)
coated
gallium‐based
metal–organic
framework
(GaMOF)
designed,
capture
antibiotic‐resistant
bacteria
(Methicillin‐resistant
Staphylococcus
aureus
,
MRSA)
as
“captor”,
rejuvenate
Methicillin
(Me)
via
disturbing
tricarboxylic
acid
(TCA)
cycle.
Then,
radially
oriented
porous
cryogel
loaded
Me
QCSGaMOF
fabricated
directional
freeze‐casting
method.
The
structure
has
effect
guiding
ingrowth
osteogenic
cells.
In
vitro
vivo
experiments
prove
advantages
as‐prepared
Me/QCSGa‐MOF@Cryogel
combating
APL Materials,
Journal Year:
2024,
Volume and Issue:
12(8)
Published: Aug. 1, 2024
MXenes,
a
novel
class
of
two-dimensional
(2D)
materials,
have
attracted
considerable
attention
in
various
fields,
especially
drug
delivery,
wound
healing,
bone
tissue
engineering,
biosensing,
and
cancer
treatment.
Thanks
to
their
remarkable
physicochemical
properties,
MXenes
hold
great
promise
for
biomedical
applications.
Concurrently,
hydrogels
composed
polymers
been
extensively
utilized
contexts.
The
unique
properties
facilitate
integration
into
bioactive
with
enhanced
functions
thereby
endowing
the
composites
multifunctional
capabilities.
MXene-reinforced
polymer
(MRPHs)
synergistically
combine
advantageous
characteristics
both
hydrogels,
making
them
highly
adaptable
other
theranostic
strategies
medical
In
this
comprehensive
review,
we
demonstrate
recent
advances
design
synthesis
MRPHs
Specifically,
introduce
analyze
methods
tailoring
by
incorporating
active
components,
including
functional
molecules,
2D
metal
ions,
natural
polymers,
drugs/genes.
We
then
discuss
applications
designed
biosensors,
therapy.
hope
that
work
provides
valuable
guidance
inspiration
readers
develop
advanced
APL Materials,
Journal Year:
2025,
Volume and Issue:
13(3)
Published: March 1, 2025
Bone
injury
is
a
prevalent
condition
in
clinical
therapy
that
can
lead
to
significant
functional
impairments
and
substantially
disrupt
the
quality
of
life
for
patients.
However,
there
has
been
limited
breakthrough
achieving
neuralized
vascularized
rapid
bone
regeneration.
In
this
study,
we
collaborated
with
recombinant
humanized
collagen
1
(rhCOL1),
native
composite
inorganic
salts
(NBCISs),
methacrylated
silk
fibroin
(SilMA),
marrow
mesenchymal
stem
cells
(BMSCs)
construct
biomimetic
organic
bio-mineralized
multifunctional
organoids
repair
defects,
regeneration
within
just
six
weeks
rabbits.
We
first
determined
optimal
concentration
SilMA
(10%)
by
comprehensively
evaluating
crosslinking,
operability,
BMSC
proliferation.
The
rhCOL1
NBCIS
mixture
was
prepared
using
ratio
3:7,
reference
bone,
subsequently
added
create
biomineralized
microenvironments
NCSilMA.
Similarly,
proportions
were
optimized
based
on
their
effects
compressive
modulus,
swelling,
degradation.
As
result,
successfully
constructed
hydrogel
scaffold
defect
repair,
characterized
excellent
biodegradability,
appropriate
strength,
good
biocompatibility,
osteoinductive
biological
function.
Finally,
BMSC-loaded
NCSilMA
(organoids)
achieved
regeneration,
up-regulated
osteogenic
genes
enhanced
cell
colonization,
collagen,
polysaccharide
deposition.
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(6), P. 417 - 417
Published: March 8, 2025
In
this
work,
we
developed
3D
ionic
liquid
(IL)
functionalized
graphene
assemblies
(GAs)
decorated
by
ultrafine
RuCu
alloy
nanoparticles
(RuCu-ANPs)
via
a
one-step
synthesis
process,
and
integrated
it
into
microfluidic
sensor
chip
for
in
situ
electrochemical
detection
of
NO
released
from
living
cells.
Our
findings
have
demonstrated
that
RuCu-ANPs
on
IL-GA
exhibit
high
density,
uniform
distribution,
lattice-shaped
arrangement
atoms,
extremely
size,
possess
electrocatalytic
activity
to
oxidation
the
electrode.
Meanwhile,
with
hierarchical
porous
structures
can
facilitate
efficient
electron/mass
transfer
at
electrode/electrolyte
interface
cell
culture.
Moreover,
graft
IL
molecules
GA
endows
hydrophilicity
facile
well-controllable
printing
Consequently,
resultant
excellent
sensing
performances
including
fast
response
time,
sensitivity,
good
anti-interference
ability,
reproducibility,
long-term
stability,
as
well
biocompatibility,
which
be
used
an
on-chip
system
culture
real-time
cells
accurate
stable
characteristics
physiological
conditions.
Infected
bone
defects,
caused
by
bacterial
contamination
following
disease
or
injury,
result
in
the
partial
loss
destruction
of
tissue.
Traditional
transplantation
and
other
clinical
approaches
often
fail
to
address
therapeutic
complexities
these
conditions
effectively.
In
recent
years,
advanced
biomaterials
have
attracted
significant
attention
for
their
potential
enhance
treatment
outcomes.
This
review
explores
pathogenic
mechanisms
underlying
infected
including
biofilm
formation
internalization
into
cells,
which
allow
bacteria
evade
host
immune
system.
To
control
infection
facilitate
repair,
we
focus
on
antibacterial
materials
regeneration.
A
detailed
introduction
is
given
intrinsically
(e.g.,
metal
alloys,
oxide
materials,
carbon-based
hydroxyapatite,
chitosan,
Sericin).
The
functionality
repair
can
be
enhanced
through
strategies
such
as
incorporation
antimicrobial
ions,
surface
modification,
combined
use
multiple
treat
defects.
Key
innovations
discussed
include
that
release
agents,
functional
contact
biomaterials,
bioresponsive
collectively
efficacy.
Research
translation
has
also
facilitated
practical
application
prevention
healing.
conclusion,
advancements
provide
promising
pathways
developing
more
biocompatible,
effective,
personalized
therapies
reconstruct
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 9, 2025
Abstract
Implant‐associated
infections
(IAIs)
are
common
and
challenging
complications
of
orthopedic
surgery.
The
physical
barrier
formed
by
biofilms
the
antioxidant
defense
system
bacteria
shield
them
from
attack
antimicrobial
agents
immune
cells,
leading
to
irreversible
bone
loss
failure
osseointegration.
To
address
these
challenges
enhance
osseointegration
in
presence
biofilm
infections,
a
sequential
therapy
strategy
is
proposed
using
an
ultrasound‐activated
nanocarrier,
PLGA@H/Se,
designed
disrupt
bacterial
defenses
subsequently
enhancing
osteogenic
differentiation.
As
expected,
when
activated
ultrasound,
induces
cavitation
effect
that
disrupts
outer
biofilm,
while
promoting
deep
delivery
encapsulated
SeNPs
peptide
HHC‐36.
target
internal
H₂S‐based
bacteria,
thereby
synergistically
bactericidal
Furthermore,
sustained
release
regulates
selenoprotein
expression,
boosts
stress
responses,
activates
Wnt/β‐catenin
pathway,
which
helps
restore
differentiation
potential
BMSCs
impaired
oxidative
damage,
both
vitro
vivo.
Collectively,
this
ultrasound‐based
facilitates
functional
under
pathological
conditions,
offering
practical
comprehensive
for
treating
IAIs.
