Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Abstract
Periodontitis,
a
chronic
inflammatory
disease,
is
the
leading
cause
of
tooth
loss
in
adults
and
one
most
prevalent
complex
oral
conditions.
Oxidative
stress
induced
by
excessive
generation
reactive
oxygen
species
(ROS)
leads
to
periodontitis,
which
closely
associated
with
pathological
processes,
including
mitochondrial
dysfunction
periodontal
cells
local
immune
dysregulation.
However,
current
treatment
modalities
that
target
single
processes
have
limited
long‐term
therapeutic
effects.
Herein,
multifunctional
Yolk–Shell
nanozyme,
Au@CeO
2
‐dimethyl
fumarate
(DMF),
comprehensively
addresses
oxidative
stress‐induced
pathophysiological
periodontitis
through
antioxidant
activity,
maintenance,
modulation
mechanisms,
described.
For
material
design
logic,
functionally
complementary
Au
CeO
formed
an
excellent
photothermally
regulated
high‐efficiency
also
provided
ideal
drug
carrier
for
DMF.
As
‐DMF
restores
dysregulation,
contributes
endogenous
ROS
elimination,
thereby
achieving
stable
In
rat
model,
photothermal
therapy
effectively
alleviated
ROS‐induced
tissue
damage
restored
homeostasis.
Altogether,
this
study
presents
novel
nanozyme
managing
alveolar
bone
under
prolonged
demonstrates
importance
comprehensive
intervention
key
design.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 31, 2024
The
complex
anatomy
and
biology
of
craniofacial
bones
pose
difficulties
in
their
effective
precise
reconstruction.
Injectable
hydrogels
(IHs)
with
water-swollen
networks
are
emerging
as
a
shape-adaptive
alternative
for
noninvasively
rebuilding
bones.
advent
versatile
nanomaterials
(NMs)
customizes
IHs
strengthened
mechanical
properties
therapeutically
favorable
performance,
presenting
excellent
contenders
over
traditional
substitutes.
Structurally,
NM-reinforced
energy
dissipative
covalently
crosslinked,
providing
the
mechanics
necessary
to
support
structures
physiological
functions.
Biofunctionally,
incorporating
unique
NMs
into
IH
expands
plethora
biological
activities,
including
immunomodulatory,
osteogenic,
angiogenic,
antibacterial
effects,
further
favoring
controllable
dynamic
tissue
regeneration.
Mechanistically,
NM-engineered
optimize
physical
traits
direct
cell
responses,
regulate
intracellular
signaling
pathways,
control
release
biomolecules,
collectively
bestowing
structure-induced
features
multifunctionality.
By
encompassing
state-of-the-art
advances
NM-integrated
IHs,
this
review
offers
foundation
future
clinical
translation
bone
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Abstract
Periodontitis,
a
chronic
inflammatory
disease,
is
the
leading
cause
of
tooth
loss
in
adults
and
one
most
prevalent
complex
oral
conditions.
Oxidative
stress
induced
by
excessive
generation
reactive
oxygen
species
(ROS)
leads
to
periodontitis,
which
closely
associated
with
pathological
processes,
including
mitochondrial
dysfunction
periodontal
cells
local
immune
dysregulation.
However,
current
treatment
modalities
that
target
single
processes
have
limited
long‐term
therapeutic
effects.
Herein,
multifunctional
Yolk–Shell
nanozyme,
Au@CeO
2
‐dimethyl
fumarate
(DMF),
comprehensively
addresses
oxidative
stress‐induced
pathophysiological
periodontitis
through
antioxidant
activity,
maintenance,
modulation
mechanisms,
described.
For
material
design
logic,
functionally
complementary
Au
CeO
formed
an
excellent
photothermally
regulated
high‐efficiency
also
provided
ideal
drug
carrier
for
DMF.
As
‐DMF
restores
dysregulation,
contributes
endogenous
ROS
elimination,
thereby
achieving
stable
In
rat
model,
photothermal
therapy
effectively
alleviated
ROS‐induced
tissue
damage
restored
homeostasis.
Altogether,
this
study
presents
novel
nanozyme
managing
alveolar
bone
under
prolonged
demonstrates
importance
comprehensive
intervention
key
design.
