Cited by Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation

Biometallic ions and derivatives: a new direction for cancer immunotherapy DOI

Lin Zhao,

Yajun Gui,

Jing Cai

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Language: Английский

Citations

Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy DOI

Youyou Li, Jing Liu, Ralph R. Weichselbaum

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions inhibitors efficiently simultaneously Herein, mitochondria-targeted nanoscale coordination polymer particle, Cu/TI, comprising Cu(II), triphenylphosphonium conjugate 5-carboxy-8-hydroxyquinoline (TI), for effective induction programmed cell death-1 (PD-L1) downregulation is reported. Upon systemic administration, Cu/TI accumulates tumor tissues induce immunogenic cancer death reduce PD-L1 expression. Consequently, promotes the intratumoral infiltration activation cytotoxic T lymphocytes greatly inhibit progression colorectal carcinoma triple-negative breast mouse models without causing obvious side effects.

Language: Английский

Citations

Copper in the colorectal cancer microenvironment: pioneering a new era of cuproptosis-based therapy DOI

Qingling Feng,

Yue Sun,

Zhe Yang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 9, 2025

Copper, an essential trace element and biochemical cofactor in humans plays a critical role maintaining health. Recent studies have identified significant association between copper levels the progression metastasis of cancer. Copper is primarily absorbed intestinal tract, often leading to imbalance ions body. Colorectal cancer (CRC), most common originating intestines, thrives environment with elevated concentrations. Current research focused on uncovering relationship CRC which has introduced new concepts such as cuproplasia cuproptosis, significantly deepening our understanding copper's influence cell proliferation death. Cuproplasia kind mediated by co-regulatory activities enzymes non-enzymatic factors, while cuproptosis refers death induced excessive copper, results abnormal oligomerization lipacylated proteins reduction iron-sulfur cluster proteins. Exploring opens avenues for treating CRC. This review aims summarize promoting colorectal cancer, dual effects tumor microenvironment (TME), strategies leveraging this unique induce Understanding holds promise establishing theoretical foundation innovative therapeutic

Language: Английский

Citations

Nanotechnology for cancer immunotherapy DOI

Xiaoqi Zheng,

Bella B. Manshian, Stefaan J. Soenen

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment DOI

Zui Tian,

Xudong Wang,

Shuai Chen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1509 - 1528

Published: Feb. 1, 2025

Abstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in progression of inflammatory diseases. Mitochondria, often referred as "power plants" cell, are essential organelles responsible critical functions such energy metabolism, material synthesis, signal transduction. functional state mitochondria closely linked macrophage polarization, prompting interest strategies that target regulate this process. To end, biomaterials with excellent targeting capabilities effective properties have been developed influence mitochondrial function polarization. However, comprehensive summary biomaterial-driven modulation control phenotypes still lacking. This review highlights polarization discusses mediated by biomaterials, including mitochondria-targeted biomaterials. Finally, prospects challenges use these explored, emphasizing their potential be translated clinic. It anticipated will serve valuable resource materials scientists clinicians development next-generation Keywords: macrophages,

Language: Английский

Citations

Copper's dual role: Reviewing its impact on liver health and disease DOI

Tongtong Pan, Jiayin Huang, Xiaodong Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114391 - 114391

Published: March 12, 2025

Language: Английский

Citations

Strategies to combat cancer drug resistance: focus on copper metabolism and cuproptosis DOI

Leyi Yao,

Baoyi Jiang,

Dacai Xu

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Cancer cells often develop tolerance to chemotherapy, targeted therapy, and immunotherapy drugs either before or during treatment. The significant heterogeneity among various tumors poses a critical challenge in modern cancer research, particularly overcoming drug resistance. Copper, as an essential trace element the body, participates biological processes of diseases, including cancers. growth many types tumor exhibits heightened dependence on copper. Thus, targeting copper metabolism inducing cuproptosis may be potential ways overcome Copper chelators have shown resistance by copper-dependent cells. In contrast, ionophores, copper-based nanomaterials, other small molecules been used induce cell death (cuproptosis) cells, drug-resistant This review summarizes regulation role resistance, providing ideas for future.

Language: Английский

Citations

The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer DOI

Ziyu Guo,

Danyao Chen,

Lei Yao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: May 8, 2025

Abstract Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependent form cell death that is crucial for tumor suppression and therapeutic resistance. As result, manipulating levels has garnered increasing interest as innovative approach to cancer therapy. In this review, we first delineate at both cellular systemic levels, clarifying copper’s protumorigenic antitumorigenic functions cancer. We then outline key milestones molecular mechanisms including mitochondria-dependent independent pathways. Next, explore cuproptosis biology, well interactions mediated by between cells immune system. also summarize emerging opportunities targeting discuss clinical associations cuproptosis-related genes. Finally, examine potential biomarkers put forward existing challenges future prospects leveraging Overall, review enhances our understanding landscape cancer, highlighting copper- or cuproptosis-based therapies treatment.

Language: Английский

Citations

Ultrasound‐Triggered Nanoparticles Induce Cuproptosis for Enhancing Immunogenic Sonodynamic Therapy DOI

Jia Huang, Fang Hu, Hanchen Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Cuproptosis, as a novel mechanism of cell death, holds significant promise for tumor therapy. However, existing studies typically employ methods to induce cuproptosis through endogenous or exogenous pathways, which often fail achieve precise control in both space and time. Herein, polymeric nanoparticles (RC NPs) are developed that enable activation acoustic tumor‐specific treatment. The fabricated via self‐assembly degradable, acoustic‐sensitive polymer (Poly RA) metal‐ion‐loadable polyphenol‐structured MPN). Ultrasound stimulation cleaved the RC NPs, generating reactive oxygen species (ROS) promoting release copper ions from Poly MPN, leading aggregation lipoylated proteins depletion iron‐sulfur cluster introduce cuproptosis. Subsequently, NPs successfully activated immune system mice, maturation antigen‐presenting cells T lymphocytes. exhibited good biosafety inhibition orthotopic patient‐derived xenograft (PDX) models. These provide promising modality treatment highly aggressive cancers valuable avenue future clinical applications.

Language: Английский

Citations

Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation DOI

Pengyu Wang, Weihua Guo, Shuyue Liu

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: May 17, 2025

Language: Английский

Citations