In situ formulation of biomaterials for disease therapy: Recent advances in peptide assembly strategies DOI

Wenmin Xiong,

Na Song,

Xiaowei Mo

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216251 - 216251

Published: Oct. 12, 2024

Language: Английский

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer DOI Creative Commons
Zhou Yang, Wei Su, Qinglin Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti-ferroptosis therapy. Through drug screening, it found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC ferroptosis. The combination HDACi and ferroptosis inducers synergically suppresses growth both in vivo vitro. Mechanically, reduces suppressor protein (FSP1) by promoting its mRNA degradation. Specifically, confirmed specifically targets HDAC1 promotes H3K27ac modification fat mass- obesity-associated gene (FTO) AlkB Homolog 5, RNA Demethylase (ALKBH5), results significant activation FTO ALKBH5. ALKBH5 N6-methyladenosine (m6A) on FSP1 mRNA, leading Crucially, lactylation HDAC1K412 essential for regulation. Both Vorinostat (SAHA) Trichostatin A (TSA) notably diminish comparison other inhibitors, exhibiting a consistent trend increasing susceptibility In conclusion, research reveals decreases sensitize can be promising therapeutic strategy CRC.

Language: Английский

Citations

4
Resistance to Immunotherapy in Non-small Cell Lung Cancer: Unraveling Causes, Developing Effective Strategies, and Exploring Potential Breakthroughs DOI

Shuang Dong,

Xiaoyu Li, Qing Huang

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101215 - 101215

Published: Feb. 26, 2025

Language: Английский

Citations

1
Co‐delivery Nano System of MS‐275 and V‐9302 Induces Pyroptosis and Enhances Anti‐Tumor Immunity Against Uveal Melanoma DOI Creative Commons
Hong Ren, Zhenkai Wu, Jia Tan

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 18, 2024

Abstract In the treatment of uveal melanoma (UVM), histone deacetylase inhibitors (HDACi) have emerged as a promising epigenetic therapy. However, their clinical efficacy is hindered by suboptimal pharmacokinetics and strong self‐rescue tumor cells. To overcome these limitations, reactive oxygen species (ROS)‐responsive nanoparticles (NPs) are designed that encapsulate HDACi MS‐275 glutamine metabolism inhibitor V‐9302. Upon reaching microenvironment, NPs can disintegrate, thereby releasing to increase level ROS V‐9302 reduce production glutathione (GSH) related self‐rescue. These synergistic effects lead lethal storm induce cell pyroptosis. When combined with programmed death protein 1 monoclonal antibodies ( α ‐PD‐1), facilitate immune infiltration, improving anti‐tumor immunity, converting “immune‐cold” tumors into “immune‐hot” tumors, enhancing memory in mice. The findings present nano‐delivery strategy for co‐delivery therapeutics metabolic inhibitors, which induces pyroptosis cells improves effectiveness chemotherapy immunotherapy.

Language: Английский

Citations

8
Multi‐Enzyme Nanoparticles as Efficient Pyroptosis and Immunogenic Cell Death Inducers for Cancer Immunotherapy DOI Creative Commons

Hekai Yang,

Guangzhao Xu, Fahui Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(44)

Published: Oct. 9, 2024

Abstract Immunotherapy represents a widely employed modality in clinical oncology, leveraging the activation of human immune system to target and eradicate cancer cells tumor tissues via endogenous mechanisms. However, its efficacy remains constrained by inadequate responses within “cold” microenvironment (TME). In this study, multifunctional nanoscale pyroptosis inducer with cascade enzymatic activity (IMZF), comprising superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione oxidase (GSHO x ), is dissociated acidic glutathione‐rich TME. The vigorous not only generates oxygen (O 2 ) alleviate hypoxia promote M2 M1 macrophage polarization but also yields reactive species (ROS) depletes (GSH) Functioning as an immunogenic cell death (ICD) activator inducer, IMZF synergistically triggers dendritic maturation inflammatory lymphocyte infiltration ICD‐associated pyroptosis, thereby reversing suppression TMEs. Consequently, it exerts inhibitory effects on both primary distal tumors. This platform‐based offers intelligent strategy for effectively overcoming tumors, providing promising avenue advanced immunotherapeutic interventions.

Language: Английский

Citations

7
Tumor-targeting Nanomaterials Based on Metal-organic Frameworks Mediate Tumor Immunotherapy by Promoting Cuproptosis and Pyroptosis in Hepatocellular Carcinoma Cells DOI Creative Commons

Xiaoyuan Yi,

Huaying Xie,

Kunzhao Huang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101745 - 101745

Published: April 1, 2025

Language: Английский

Citations

0
Immunogenic Cell Death and Metabolic Reprogramming in Cancer: Mechanisms, Synergies, and Innovative Therapeutic Strategies DOI Creative Commons
Jie Jiang, Ying Yan, Chunhui Yang

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 950 - 950

Published: April 12, 2025

Immunogenic cell death (ICD) is a promising cancer therapy where dying tumor cells release damage-associated molecular patterns (DAMPs) to activate immune responses. Recent research highlights the critical role of metabolic reprogramming in cells, including Warburg effect, oxidative stress, and lipid metabolism, modulating ICD shaping microenvironment. These changes enhance activation, making tumors more susceptible surveillance. This review explores mechanisms linking mitochondrial endoplasmic reticulum (ER) ferroptosis. It also discusses innovative therapeutic strategies, such as personalized combination therapies, inhibitors, targeted delivery systems, improve efficacy. The future immunotherapy lies integrating activation overcome evasion, with multi-omics approaches microbiome modulation offering new avenues for enhanced treatment outcomes.

Language: Английский

Citations

0
Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives DOI Creative Commons
Chen Huang, Jiayi Li, Ruiyan Wu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 3, 2025

Pyroptosis is a distinct form of programmed cell death characterized by the rupture membrane and robust inflammatory responses. Increasing evidence suggests that pyroptosis significantly affects tumor microenvironment antitumor immunity releasing damage-associated molecular patterns (DAMPs) pro-inflammatory mediators, thereby establishing it as pivotal target in cancer immunotherapy. This review thoroughly explores mechanisms underlying pyroptosis, with particular focus on inflammasome activation gasdermin family proteins (GSDMs). It examines role pyroptotic reshaping immune (TIME) involving both cells, discusses recent advancements targeting pathways through therapeutic strategies such small molecule modulators, engineered nanocarriers, combinatory treatments checkpoint inhibitors. We also advances future directions to enhance immunotherapy inhibitors, adoptive therapy, vaccines. study suggested offers promising avenue amplify responses surmount resistance existing immunotherapies, potentially leading more efficacious treatments.

Language: Английский

Citations

0
In situ formulation of biomaterials for disease therapy: Recent advances in peptide assembly strategies DOI

Wenmin Xiong,

Na Song,

Xiaowei Mo

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216251 - 216251

Published: Oct. 12, 2024

Language: Английский

Citations

2