Dual‐Defect Nitrogen‐Rich Carbon Nitride‐Based Heterostructural Nanocatalyst for Improving the Therapeutic Efficacy of αPD‐1 via Tumor Immune Microenvironment Remodelling DOI
Tingting Hu, Chuan Hu,

Yinwen Ji

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Abstract Low immunogenicity, insufficient immune infiltrates, and inhibitive microenvironment of tumors ruthlessly weakened the therapeutic efficacy immunotherapies. How to improve therapy by reshaping tumor still remains a challenge that needs be urgently addressed. Here, novel dual‐defect nitrogen‐rich carbon nitride‐based heterostructural nanocatalyst (CNO@CuMS) possessing brilliant piezocatalytic H 2 O generation, sonocatalytic 1 Fenton‐like catalytic •OH cell cuproptosis inducing properties are developed. Accompanied ultrasonic treatment, immunogenic death (ICD) subsequent releasing damage‐associated molecular patterns (DAMPs) cells successfully triggered CNO@CuMS, which resulted in activation systematic antitumor response enhanced infiltration CD8 + cytotoxic T lymphocytes natural killer (NK) at site. The large quantitatively generated reactive oxygen species (ROS) also promoted polarization M2‐type macrophage M1‐type as well. Benefitting from this remodelling effect, remarkable malignant orthotopic osteosarcoma is achieved employing CNO@CuMS α PD‐1 combination strategy under with no significant side effects observed. This research not only proposes method fabricate high proformance but provides new realize highly efficient bone during clinical practice.

Language: Английский

Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy DOI Creative Commons
Guangjian Hou, Yukun Xu, Chunhua Wang

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.

Language: Английский

Citations

0
A comprehensive review on the recent applications of nanozymes in breast cancer therapy and diagnosis DOI Creative Commons

Amir Kashtiaray,

Mahdi Karimi, Mostafa Ghafori-Gorab

et al.

Materials Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nanozymes have been developed as engineered nanomaterials that mimic the catalytic functions of natural enzymes.

Language: Английский

Citations

0
Catalytic mechanism and biomedical applications of diatomic nanozymes DOI Open Access
Xiaonan Wang,

Lingjie Hou,

Mengyu Dang

et al.

Microstructures, Journal Year: 2025, Volume and Issue: 5(3)

Published: April 21, 2025

The diatomic nanozymes (DANs) represent a class of nanomaterials containing dual metals as active centers with enzyme-like activity inspired by natural enzymes. They hold unique catalytic properties caused their dual-atom structure, which have attracted significant attention. mechanism DANs may involve synergistic interactions between neighboring metal atoms and the regulation electron arrangement near center, enhancing specificity. excellent exceptional stability make promising candidates for developing sensitive biosensors capable precisely detecting disease markers. Furthermore, show great promise antitumor therapeutic agents, offering enhanced efficacy while minimizing side effects. This review outlines biomedical applications DANs. discussion section highlights challenges prospects in development DANs, insights future research endeavors this field.

Language: Английский

Citations

0
Dual‐Defect Nitrogen‐Rich Carbon Nitride‐Based Heterostructural Nanocatalyst for Improving the Therapeutic Efficacy of αPD‐1 via Tumor Immune Microenvironment Remodelling DOI
Tingting Hu, Chuan Hu,

Yinwen Ji

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Abstract Low immunogenicity, insufficient immune infiltrates, and inhibitive microenvironment of tumors ruthlessly weakened the therapeutic efficacy immunotherapies. How to improve therapy by reshaping tumor still remains a challenge that needs be urgently addressed. Here, novel dual‐defect nitrogen‐rich carbon nitride‐based heterostructural nanocatalyst (CNO@CuMS) possessing brilliant piezocatalytic H 2 O generation, sonocatalytic 1 Fenton‐like catalytic •OH cell cuproptosis inducing properties are developed. Accompanied ultrasonic treatment, immunogenic death (ICD) subsequent releasing damage‐associated molecular patterns (DAMPs) cells successfully triggered CNO@CuMS, which resulted in activation systematic antitumor response enhanced infiltration CD8 + cytotoxic T lymphocytes natural killer (NK) at site. The large quantitatively generated reactive oxygen species (ROS) also promoted polarization M2‐type macrophage M1‐type as well. Benefitting from this remodelling effect, remarkable malignant orthotopic osteosarcoma is achieved employing CNO@CuMS α PD‐1 combination strategy under with no significant side effects observed. This research not only proposes method fabricate high proformance but provides new realize highly efficient bone during clinical practice.

Language: Английский

Citations

0