Topics in Current Chemistry, Journal Year: 2022, Volume and Issue: 381(1)
Published: Dec. 10, 2022
Language: Английский
ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405
Published: July 24, 2023
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.
Language: Английский
Citations
189
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(4), P. 1456 - 1490
Published: Jan. 1, 2023
This review summarizes the synthesis, characterization and applications of AIE-active micelles. It is expected that this can guide future design micelle materials with fascinating structures functionalities.
Language: Английский
Citations
69
ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 1845 - 1878
Published: Jan. 19, 2023
The discovery of aggregation-induced emission (AIE) phenomenon in 2001 has had a significant impact on materials development across different research disciplines. AIE-active have been widely exploited for various applications optoelectronics, sensing, biomedical, and stimuli-responsive systems, etc. This is made possible by integrating AIE features with other fields science engineering, such as nanoscience nanotechnology. extensively employed, particularly biomedical applications, biosensing, bioimaging, theranostics. However, AIE-based nanotechnology comparatively less, although there increasing activities recent years. Given the significance potential marriage between hallmark development, this review article summarizes showcases latest efforts nanomaterials, including nanomaterials synthesis their nonbiomedical functional coatings, systems. A perspective outlook nanostructured relevant will be provided, giving an insight into how to design nanostructures well beyond domain.
Language: Английский
Citations
67
Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(13), P. 6019 - 6027
Published: March 27, 2022
Natural systems transfer chiral information across multiple length scales through dynamic supramolecular interaction to accomplish various functions. Inspired by nature, many exquisite artificial have been developed, in which controlling the chirality holds key completing specific tasks. However, achieve precise and non-invasive control modulation of these remains challenging. As a stimulus, light can be used remotely with high spatiotemporal precision. In contrast common molecular switches, synthetic motor act as multistate chiroptical switch unidirectional rotation, offering major potential regulate more complex Here, we present light-driven motor-based polymer, intrinsic is transferred nanofibers, rotation motors governs morphology polymer. The resulting polymer also exhibits light-controlled aggregation-induced emission. These findings photochemically tunable system water pave way for developing motor-driven materials.
Language: Английский
Citations
66
ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 13992 - 14006
Published: Aug. 12, 2022
Dendritic cell (DC)-derived small extracellular vesicles (DEVs) are recognized as a highly promising alternative to DC vaccines; however, the clinical testing of DEV-based immunotherapy has shown limited therapeutic efficacy. Herein, we develop straightforward strategy in which DCs serve reactor exocytose high-efficient DEV-mimicking aggregation-induced emission (AIE) nanoparticles (DEV-AIE NPs) at scaled-up yield for synergistic photodynamic immunotherapy. Exocytosed DEV-AIE NPs inherit not only immune-modulation proteins from parental DCs, enabling T activation, but also loaded AIE-photosensitizer MBPN-TCyP, inducing superior immunogenic death (ICD) by selectively accumulating mitochondria tumor cells. Eventually, elicits dramatic immune responses and efficient eradication primary tumors, distant metastases. In addition, cancer stem cells (CSCs) 4T1 CT26 solid tumors were significantly inhibited functional NPs. Our work presents facile method cellular generation EV-biomimetic demonstrates that integration DEVs AIE photosensitizers is powerful direction production anticancer nanovaccines.
Language: Английский
Citations
53
Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 154, P. 424 - 442
Published: Oct. 29, 2022
Language: Английский
Citations
44
ACS Nano, Journal Year: 2023, Volume and Issue: 17(24), P. 25205 - 25221
Published: Dec. 13, 2023
Targeted and controllable drug release at lesion sites with the aid of visual navigation in real-time is great significance for precise theranostics cancers. Benefiting from marvelous features (e.g., bright emission phototheranostic effects aggregates) aggregation-induced (AIE) materials, constructing AIE-based multifunctional nanocarriers that act as all-arounders to integrate multimodalities highly desirable. Here, an intelligent nanoplatform (P-TN-Dox@CM) homologous targeting, release, vivo dual-modal imaging chemo-photothermal synergistic therapy proposed. AIE photothermic agent (TN) anticancer (Dox) are encapsulated thermo-/pH-responsive nanogels (PNA), tumor cell membranes camouflaged onto surface nanogels. Active targeting can be realized through derived source membranes, which advantageously elevates specific delivery sites. After being engulfed into cells, exhibit a burst low pH. The near-infrared (NIR) photoinduced local hyperthermia activate severe cytotoxicity further accelerate thus generating enhanced thoroughly eradicate tumors. Moreover, P-TN-Dox@CM could achieve NIR-fluorescence/photothermal monitor dynamic distribution therapeutics real-time. This work highlights potential smart versatile combating
Language: Английский
Citations
33
Small, Journal Year: 2023, Volume and Issue: 19(26)
Published: March 21, 2023
Abstract Fluorescent polymer particles have witnessed an increasing interest in recent years, owing to their fascinating physicochemical properties as well wide‐ranging applications. In this review, the state‐of‐the‐art research progress of fluorescent past five years is summarized. First, synthesis protocols for particles, including emulsion polymerization, precipitation dispersion suspension nanoprecipitation, self‐assembly, and post‐polymerization modification, are presented detail. Then, applications resulting beguiling anticounterfeiting, chemical sensing, biomedicine, illustrated. Finally, challenges opportunities that exist field pointed out. This review aims offer important guidance stimulate more attention rapidly developing field.
Language: Английский
Citations
31
Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 141, P. 101677 - 101677
Published: April 22, 2023
Language: Английский
Citations
30
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 2, 2024
Abstract The bottom-up molecular science research paradigm has greatly propelled the advancement of materials science. However, some organic molecules can exhibit markedly different properties upon aggregation. Understanding emergence these and structure-property relationship become a new hotspot. In this work, by taking unique closed-form rhodamines-based aggregation-induced emission (AIE) system as model compounds, we investigated their luminescent underlying mechanism deeply from top-down viewpoint. Interestingly, rhodamine-based AIE did not display expected behavior under high-viscosity or low-temperature conditions. Alternatively, finally found that conformation change aggregation induced intramolecular charge transfer played significant role for phenomenon rhodamine derivatives. application probe in food spoilage detection was also explored.
Language: Английский
Citations
16