Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(32)
Published: Oct. 14, 2024
Abstract
Chronic
wounds
are
characterized
by
long‐term
inflammation,
including
diabetic
ulcers,
traumatic
etc.,
which
provide
an
optimal
environment
for
bacterial
proliferation.
At
present,
antibiotics
the
main
clinical
treatment
method
chronic
wound
infections.
However,
overuse
of
may
accelerate
emergence
drug‐resistant
bacteria,
poses
a
significant
threat
to
human
health.
Therefore,
there
is
urgent
need
develop
new
therapeutic
strategies
Nanozyme‐based
antimicrobial
therapy
(NABT)
emerging
strategy
with
broad‐spectrum
activity
and
low
drug
resistance
compared
traditional
antibiotics.
NABT
has
shown
great
potential
as
catalyzing
generation
reactive
oxygen
species
(ROS)
its
enzyme‐like
catalytic
properties,
producing
powerful
bactericidal
effect
without
developing
resistance.
cascade
technology
offers
approach
infection
control,
effectively
improving
efficacy
activating
cascades
against
cell
membranes
intracellular
DNA
while
minimizing
side
effects.
it
worth
noting
that
this
still
in
early
stages
research.
This
article
comprehensively
reviews
classification,
current
methods
infection,
different
types
nanozymes,
application
nanozyme
reaction
therapy,
future
challenges
prospects.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(31), P. 7519 - 7531
Published: Jan. 1, 2024
A
solvothermal
method
and
the
subsequent
heat
treatment
process
were
developed
to
fabricate
hollow
ZnO
particles
with
hierarchical
pores
on
a
large
scale.
The
as-obtained
hollow,
porous
microspheres
tunable
sizes,
high
specific
surface
areas,
pH
sensitivity,
antibacterial
properties,
adsorption
capacities
showed
significant
advantages
for
drug
delivery.
Sprayable
hydrogels
containing
curcumin
nanoparticles
(CNPs)
prepared
accelerate
wound
healing.
water-dispersed
CNPs
promoted
both
migration
of
fibroblasts
angiogenesis
an
aqueous
solution
Pluronic
F127
(a
temperature-sensitive
phase-change
hydrogel
material)
was
shown
be
effective
choice
medical
dressings.
experimental
data
suggest
that
can
loaded
additional
achieve
continuous
long-term
therapeutic
effects.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(2), P. 295 - 295
Published: Jan. 29, 2025
This
review
provides
an
overview
of
recent
research
and
advancements
in
infection
prevention
the
treatment
drug-resistant
bacterial
diseases.
Cefiderocol,
a
novel
siderophore
cephalosporin,
has
demonstrated
effectiveness
against
carbapenem-resistant
bacteria
such
as
Pseudomonas
aeruginosa
Acinetobacter
baumannii.
Clinical
trials,
including
APEKS-NP
CREDIBLE-CR,
affirm
its
efficacy
for
hospital-acquired
pneumonia
(HAP)
but
highlight
concerns
over
increased
mortality
due
to
severe
renal
complications.
Cefiderocol
shown
superior
outcomes
complicated
urinary
tract
infections
(cUTI)
compared
imipenem–cilastatin.
A
comparison
colistin
monotherapy
versus
combination
therapy
with
meropenem
revealed
no
significant
improvement
clinical
noted
delays
resistance
development.
Colistin–rifampicin
showed
potential
benefits
colistin-resistant
baumannii,
although
results
were
not
statistically
significant.
SPR206,
polymyxin
derivative,
durlobactam,
β-lactamase
inhibitor,
show
promise
addressing
these
resistant
strains,
durlobactam
demonstrating
sulbactam
Additional
studies
investigated
antibiotic
strategies
infections,
cefoperazone–sulbactam
tigecycline,
examined
infection-prevention
surgical
settings,
comparing
chlorhexidine–alcohol
povidone–iodine.
highlights
importance
optimizing
regimens
infection-control
measures
across
various
healthcare
neonatology
care.
Journal of Tropical Medicine,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:
Staphylococcus
epidermidis
is
an
important
cause
of
nosocomial
infections
in
children.
The
study
undertaken
identified
antibiotic
resistance
markers
among
biofilm‐forming
S.
epidermidis.
Methods:
A
total
105
bacteremia‐positive
samples
from
hospitalized
children
were
processed
for
identification
using
species‐specific
rdr
gene.
Phenotypic
was
checked
through
Kirby–Bauer
disc
diffusion
method.
96‐well
microtiter
plate
assays
and
PCR
used
biofilm
production
antibiotic‐resistant
genes,
respectively.
Results:
Among
clinical
isolates,
gene
detected
34
(32.38%)
isolates.
isolates
exhibited
formation
(
n
=
34;
100%).
Multidrug‐resistant
(MDR)
pattern
observed
,
while
the
frequency
MDR
higher
very
strong
18;
52.9%,
p
≤
0.002)
as
compared
to
weak
6;
17.6%).
All
strains
resistant
cefoxitin,
penicillin,
augmentin
High
against
erythromycin
29;
85.29%)
ciprofloxacin
25;
73.5%).
displayed
complete
susceptibility
100%)
toward
vancomycin,
tetracycline,
linezolid.
methicillin
mecA
85.2%,
0.000),
msrA
19;
55.7%)
beta‐lactamase
blaZ
17;
50%)
detected.
Detection
94.4%),
8;
44.4%)
11;
61.1%)
significantly
0.0052)
correlated
with
.
Conclusion:
Biofilm
associated
resistance.
study’s
result
will
help
understand
molecular
mechanism
antimicrobial
pediatric
patients.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(5), P. 1066 - 1066
Published: April 28, 2025
Background/Objectives:
Urinary
tract
infections
(UTIs)
represent
a
significant
public
health
challenge,
with
Escherichia
coli
being
the
primary
causative
pathogen.
The
rise
in
antimicrobial
resistance
(AMR),
further
intensified
by
shifts
antibiotic
prescribing
practices
during
and
after
COVID-19
pandemic,
poses
substantial
difficulties
treatment
optimization
clinical
management.
Methods:
This
retrospective
study
analyzed
644
E.
strains
from
urine
samples
collected
southeastern
Romanian
hospital
two
periods:
pre-pandemic
(2018–2019,
N
=
361)
post-pandemic
(2023–2024,
283).
Antimicrobial
susceptibility
was
assessed
using
VITEK
automated
system
for
key
classes.
Results:
A
increase
fluoroquinolone
observed,
especially
ciprofloxacin
(p
0.02),
alongside
rising
ceftriaxone
0.004),
suggesting
spread
of
ESBL-producing
strains.
Resistance
to
trimethoprim/sulfamethoxazole,
ampicillin,
amoxicillin/clavulanic
acid
remained
high,
limiting
their
empirical
use.
Carbapenem
low
>
0.1),
while
nitrofurantoin
fosfomycin
retained
high
efficacy
0.26
p
0.64).
Conclusions:
period
showed
concerning
fluoroquinolones
third-generation
cephalosporins,
highlighting
need
stricter
stewardship.
Carbapenems
remain
effective
severe
infections,
are
reliable
first-line
options
uncomplicated
UTIs.
Continuous
AMR
surveillance
is
essential
optimize
curb
multidrug-resistant
