Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
unknown, P. 101419 - 101419
Published: Dec. 1, 2024
Hepatocellular
carcinoma
(HCC)
is
a
major
public
health
threat
due
to
its
high
incidence
and
mortality
rates.
Transcatheter
arterial
chemoembolization
(TACE),
the
primary
treatment
for
intermediate-to-advanced
hepatocellular
(HCC),
commonly
utilizes
embolic
agents
loaded
with
anthracycline-based
cytotoxic
drugs.
Post-TACE,
hypoxic
microenvironment
in
tumor
induced
by
embolization
stimulates
formation
of
new
blood
vessels,
potentially
leading
revascularization
diminishing
TACE's
efficacy.
In
clinical
practice,
combined
therapy
liver
cancer
using
TACE
oral
targeted
drugs
often
encounters
limitation
that
cannot
efficiently
reach
site
following
TACE.
We
have
developed
chondroitin
sulfate
microspheres
(CMs)
capable
encapsulating
both
drug
idarubicin
(Ida)
vascular
inhibitor
Lenvatinib
(Len),
thereby
achieving
triple
therapeutic
effect
on
cancer:
starvation,
toxicity,
efficient
inhibition
neovascularization.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 10, 2024
The
persistent
challenge
of
healing
infectious
wounds
and
the
rise
bacterial
resistance
represent
significant
hurdles
in
contemporary
medicine.
In
this
study,
based
on
natural
small
molecule
drug
Rhein
self-assembly
to
form
hydrogels
coordinate
assembly
with
silver
ions
(Ag
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(42), P. 28894 - 28909
Published: Oct. 9, 2024
Self-assembly
of
hydrogels
for
mechanical
support
and
drug
delivery
has
been
extensively
researched
in
traumatic
brain
injury
(TBI),
where
treatment
options
are
limited.
The
chief
challenge
is
that
most
self-assembled
rely
on
high
molecular
carriers
or
the
incorporation
exogenous
inactive
substances
as
mediators.
It
difficult
these
systems
to
achieve
clinical
translation
due
concerns
regarding
biological
safety.
Here
we
report
a
small
molecule
hydrogel
(GBR-gel)
loading
drugs
(glycyrrhizic
acid,
berberine,
rhein)
originated
from
popular
Chinese
medicines
without
additional
components
under
physiological
conditions.
In
long
run,
GBR-gel
possesses
several
advantages,
including
ease
preparation,
cost-effectiveness,
biocompatibility.
As
proof-of-concept,
allows
prompt
administration
at
site
exert
potent
pharmacodynamic
effects.
Further
single-cell
RNA
sequencing
experimental
validation
indicated
can
effectively
rescue
suppressed
glutamatergic
synapse
pathway
after
TBI,
thereby
attenuating
inflammatory
responses
neural
impairments.
Our
work
provides
an
alternative
strategy
timely
intervention
TBI.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Cationic
photosensitizers
(PSs)
offer
many
intriguing
advantages,
in
addition
to
generating
heat
or
reactive
oxygen
species
for
cancer
phototherapy.
However,
the
preparation
of
cationic
PSs
with
enhanced
near-infrared
(NIR)
absorption
remains
a
significant
challenge.
In
this
work,
we
have
synthesized
PS
TPBBT,
which
incorporates
strong
electron-withdrawing
unit,
benzobisthiadiazole,
and
four
terminal
pyridinium
groups.
It
self-assembles
into
mixed
H/J
aggregated
state
maximal
peak
at
620
nm
but
coassembles
negatively
charged
planar
small
molecules
form
sole
J-aggregates.
Following
strategy,
coassemble
TPBBT
rhein,
planar,
anionic
traditional
Chinese
medicine
an
anticancer
activity,
allows
near
100
bathochromic
shift
improves
photothermal
conversion
efficiency
(PCE)
from
6.4
60.4%
under
808
laser
irradiation.
Additionally,
coassembling
significantly
enhances
cellular
uptake
rhein
through
effect.
The
coassembly
(TPBBTein)
can
completely
eliminate
4T1
tumors
on
mouse
models,
validating
that
facile
strategy
not
only
tune
NIR
J-aggregate
molecular
also
promotes
efficient,
symbiotic
combination
therapy
chemotherapy.
