Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 16, 2024

Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the immune system against cancer. However, immunosuppressive tumor microenvironment (TIME) poses challenge to triggering strong responses with single treatment, thus limiting therapeutic effect immunotherapy. In this study, dual-targeted nano delivery (GOx@FeNPs) combined αPD-L1 checkpoint blocker inhibit colorectal (CRC) progression by mediating PTT, ferroptosis and anti-tumor response. Briefly, specific was achieved cyclic arginine glycyl aspartate (cRGD) peptide anisamide (AA) GOx@FeNPs had good photothermal realize PTT induce ICD, deplete glutathione (GSH) catalyze production reactive oxygen species (ROS) from endogenous H

Language: Английский

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A Facile Approach To Develop Ion Pair Micelles Satellited Freshly Derived Neutrophils For Targeted Tumor Therapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Immune cells show enormous potential for targeted nanoparticle delivery due to their intrinsic tumor-homing skills. However, the immune can internalize nanoparticles, leading cellular functional impairments, degradation of and delayed release drugs from cells. To address these issues, this study introduces an approach synthesis freshly derived neutrophils (NUs)-based nanocarriers system where NUs are surfaced by dialdehyde alginate-coated self-assembled micelles loaded with mitoxantrone (MIT) indocyanine green (ICG) (i.e., dA(MI@IPM)s) stimuli-responsive tumor-targeted therapy. Here, dA(MI@IPM)s not internalized NUs, but they anchored on membrane via distearoylphosphatidylethanolamine-polyethylene glycol-polyethylenimine anchors. Owing natural recruitment ability tumor microenvironment, NUs-anchored accumulation is higher at site than free dA(MI@IPM)s, readily detach get in The disassembles inside cancer upon near-infrared irradiation photosensitizing effect ICG, releasing MIT significantly inhibiting growth. This simple fast prepare, opening up exciting possibilities personalized treatment using patient's autologous NUs.

Language: Английский

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Functional Hydrogels Promote Chronic Infectious Wound Healing by Re-rousing Macrophage M1 and Inducing Bacterial Copper-Like Death

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101571 - 101571

Published: Feb. 14, 2025

Language: Английский

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Oxygen/siRNA-carrying fluoro-nanosensitizers for radio-immunotherapy sensitization

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Tumor cell-derived engineered exosome enhances effective immunotherapy for orthotopic glioblastoma and its recurrences

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102748 - 102748

Published: April 8, 2025

Language: Английский

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Self‐Propelled Bacteria‐Mediated In Situ Biosynthesis of MnS Nanoparticles for Remodeling Tumor Microenvironment to Amplify cGAS‐STING Pathway for Antitumor Immunity

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Abstract cGAS‐STING pathway, an important innate immune signaling has attracted extensive attention in anti‐tumor immunotherapy research. However, the limited delivery ratio of STING agonists and lactate‐induced lactylation present significant challenges advancing antitumor response. Herein, natural anaerobic sulfate‐reducing bacteria (SRB) are utilized as a biofactory to situ biosynthesize MnS nanoparticles (MnS@SRB) for amplifying MnS‐activated responses through continuous lactate depletion by SRB. After intravenous injection, MnS@SRB can actively migrate tumor tissues via SRB‐mediated hypoxia targeting, further continually release H 2 S Mn 2+ acidic microenvironment. stimulates mitochondrial dysfunction induces DNA leakage, which is then recognized cGAS activate pathway. augments STING‐mediated secretion type I interferons inflammatory factors. Importantly, effectively metabolize tumors, thereby alleviating response regulating macrophage phenotype M1‐type, reducing tumor‐infiltrating regulatory T cells increasing CD8 + level, enhancing both adaptive immunosurveillance. As result, inhibite tumors growth metastasis. Therefore, MnS@SRB‐based system enables efficient activator immunosuppressive microenvironment remodeling, opening new avenue synergistically enhanced activation.

Language: Английский

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Novel combination therapy using recombinant oncolytic adenovirus silk hydrogel and PD-L1 inhibitor for bladder cancer treatment

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 18, 2024

Recombinant oncolytic adenovirus offers a novel and promising cancer treatment approach, but its standalone efficacy remains limited. This study investigates combination strategy by co-administering recombinant Adv-loaded silk hydrogel with PD-L1 inhibitor for patients bladder to enhance outcomes. Bladder tissues from mice were collected subjected single-cell sequencing, identifying CRB3 as key gene in malignant cells. Differential expression functional enrichment analyses performed, validating CRB3's inhibitory role through vitro experiments showing suppression of cell proliferation, migration, invasion. adenoviruses encoding GM-CSF constructed encapsulated drug loading release efficiency. In vivo demonstrated that the nano-composite significantly inhibited tumor growth increased immune infiltration tissues. Co-administration (Adv-CRB3@gel) enhanced T-cell killing. The improves outcomes effectively recruiting T cells, providing therapeutic strategy.

Language: Английский

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Aptamer-Modified Tetrahedral Framework Nucleic Acid Synergized with TGF-β3 to Promote Cartilage Protection in Osteoarthritis by Enhancing Chondrogenic Differentiation of MSCs

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(38), P. 50484 - 50496

Published: Sept. 16, 2024

Characterized by progressive and irreversible degeneration of the articular cartilage (AC), osteoarthritis (OA) is most common chronic joint disease, there no cure for OA at present. Recent studies suggest that enhancing recruitment endogenous mesenchymal stem cells (MSCs) to damaged a promising therapeutic strategy repair. Tetrahedral framework nucleic acid (tFNA) novel DNA nanomaterial has shown great potential in field biomedical science. Transforming growth factor-beta 3 (TGF-β3), vital member highly conserved TGF-β superfamily, considered induce chondrogenesis. A 66-base aptamer named HM69 reported identify recruit MSCs. In this study, HM69-modified tFNAs were successfully self-assembled used load TGF-β3 when disulfide bonds combined. We confirmed successful synthesis final composition, HM69-tFNA@TGF-β3 (HTT), PAGE, dynamic light scattering, atomic force microscopy. The results vitro experiments showed HTT effectively induced MSC proliferation, migration, chondrogenic differentiation. addition, HTT-treated MSCs protect chondrocytes. DMM mice, injection improved outcome mouse pain symptoms AC degeneration. conclusion, study innovatively combined with tFNA, an additional sequence was loaded on tFNA better-targeted demonstrated its role promoting chondrogenesis protection, indicating it might be therapy.

Language: Английский

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Synergistic phototherapy using chitosan-enhanced antimonene nanosheets for effective cancer treatment

Journal of Nanoparticle Research, Journal Year: 2024, Volume and Issue: 27(1)

Published: Dec. 20, 2024

Language: Английский

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