Synlett,
Journal Year:
2024,
Volume and Issue:
35(16), P. 1906 - 1908
Published: March 20, 2024
Abstract
An
attempted
aryl
selenium-catalyzed
formation
of
cis-chlorohydrins
from
alkenes
was
unsuccessful
but
led
to
an
electrochemical
investigation
for
the
trans-selective
chloroformyloxylation
cyclic
and
acyclic
in
moderate
good
yields.
Interestingly,
when
1,1-disubstituted
were
used,
corresponding
vinyl
chloride
derivatives
obtained,
application
1-phenylcyclohex-1-ene
allyl
derivative.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
11(2), P. 597 - 630
Published: Nov. 23, 2023
This
review
highlights
the
recent
progress
in
electrochemical
difunctionalization
of
alkenes
and
alkynes
involving
C–S/Se
bond
formation
to
access
organochalcogen
frameworks.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(10), P. 2815 - 2820
Published: Jan. 1, 2022
A
regio-
and
stereoselective
electrochemical
approach
for
the
selenoalkylation
of
alkynes
with
1,3-dicarbonyl
compounds
diselenides
has
been
developed.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(32), P. 6293 - 6313
Published: Jan. 1, 2022
As
one
of
the
most
important
structural
units
in
pharmaceuticals
and
medicinal
chemistry,
quinazolinone
its
derivatives
exhibit
a
wide
range
biological
pharmacological
activities,
including
anti-inflammatory,
antitubercular,
antiviral,
anticancer
etc.
In
particular,
2,3-fused
quinazolinones
have
attracted
much
attention
because
rings
fused
to
2,3-positions
improve
their
rigidity
planarity.
Their
synthetic
strategies
made
great
advances
recent
years.
Therefore,
this
review
focuses
on
novel
for
synthesis
from
2017
2022,
such
as
difunctionalization
alkenes,
ring-opening
easily
available
small
rings,
dehydrogenative
cross-coupling
reactions,
transition-metal
catalyzed
cyclizations,
cycloadditions,
other
cascade
reactions.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(19), P. 4972 - 5027
Published: Jan. 1, 2023
This
review
comprehensively
summarizes
the
dichalcogenative
functionalization
of
unsaturated
compounds
over
past
decade.
The
scopes,
limitations
and
detailed
reaction
mechanisms
are
also
discussed.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(22)
Published: March 6, 2023
Radical
additions
onto
olefins
have
surfaced
as
an
increasingly
powerful
strategy
for
the
synthesis
of
difunctionalized
scaffolds.
However,
despite
major
advances,
known
approaches
continue
to
be
largely
limited
two
manifolds,
namely
1,2-difunctionalization
alkenes
and
remote
difunctionalization
via
hydrogen
atom
transfer
(HAT).
Herein,
we
describe
a
mechanistically
distinct
approach
by
photoinduced
carbon-carbon
(C-C)
activation/ring-opening
access
γ,δ-unsaturated
aldehydes
from
methylenecyclobutanols
sulfonyl
chlorides
strain
release.
Remarkably,
motif
on
products
was
easily
removed
another
photocatalytic
process,
which
enabled
concise
assembly
natural
product
alatanone
A.
The
synthetic
utility
our
reflected
versatile
functional
group
tolerance,
ample
substrate
scope,
scalability.
photocatalysis
represents
conceptually
alternative
existing
1,4-diversifications,
with
double
bond
remaining
in
thus
obtained
products.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(12)
Published: Jan. 24, 2023
A
simple
process
for
the
oxy-monofluoromethylation
of
alkenes
is
described.
In
combination
with
visible-light
copper(I)
photoredox
catalysis,
an
easily
accessible
iodine(III)
reagent
containing
monofluoroacetoxy
ligands
serves
as
a
powerful
source
monofluoromethyl
(CH2
F)
radical,
enabling
step
economical
synthesis
γ-fluoro-acetates
from
broad
range
olefinic
substrates
under
mild
conditions.
Applications
to
late-stage
diversification
derived
complex
molecules,
amino
acids
and
fluoromethylated
heterocycles
are
also
demonstrated.
ChemistrySelect,
Journal Year:
2022,
Volume and Issue:
7(12)
Published: March 23, 2022
Abstract
Nitriles
unveil
widespread
applications
in
pharmaceuticals,
agrochemicals,
textiles,
rubber,
polymers,
and
constitute
a
significant
intermediate
several
organic
transformations,
necessitating
the
design
of
simple
environmentally
benign
pathways
for
their
synthesis.
Over
recent
years,
electro‐organic
reactions
have
found
attention
developing
effective
selective
They
possess
advantages:
high
atom
economy,
selectivity,
minimal
waste
production,
shorter
routes
to
multistep
traditional
reactions.
The
development
novel
strategies
greener
sustainable
synthesis
nitriles
is
therefore
commendable.
This
review
focuses
on
analyzing
various
methods
used
electrochemical
using
phase
transfer
catalyst,
N‐oxoammonium
salts
mediated
electrocatalysis,
iodine‐mediated
anodic
oxidations
aldoximes.
In
addition,
trends
including
via
C−H
cyanation,
domino
oxidation,
bio
metal‐ligand
cooperative
been
discussed.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(18), P. 3308 - 3313
Published: May 2, 2023
A
scalable
electrochemical
difunctionalization
of
gem-difluoroalkenes
to
structurally
versatile
difluoro
motifs
was
achieved.
This
methodology
features
reagent-free
conditions,
good
functional
group
tolerance,
and
a
relatively
broad
substrate
scope.
Meanwhile,
the
electrolysis
protocol
is
easy
handle,
products
show
regio-
chemoselectivity.
The
reaction
mechanism
also
preliminarily
studied.
Organic & Biomolecular Chemistry,
Journal Year:
2025,
Volume and Issue:
23(10), P. 2323 - 2357
Published: Jan. 1, 2025
In
recent
years,
significant
achievements
have
been
made
in
the
field
of
electroorganic
chemistry
regarding
difunctionalization
alkenes.
Researchers
developed
innovative
strategies
utilizing
unique
reactivity
electrochemical
processes
to
synthesize
complex
molecules
with
high
regioselectivity
and
stereoselectivity.
This
technology
is
widely
applied
total
synthesis
natural
products
pharmaceutical
industry.
article
reviews
research
progress
alkenes
through
three
different
radical-mediated
pathways
over
past
five
years.
It
includes
discussions
on
1,2-stereoselective
non-diastereoselective
reactions,
rearrangements,
intramolecular
migrations,
cyclization
processes.
The
summary
emphasizes
electrode
designs,
reaction
mechanisms,
integration
other
emerging
technologies,
highlighting
potential
this
method
modern
organic
chemistry.
Additionally,
it
aims
address
current
challenges
propose
possible
solutions,
providing
a
promising
direction
for
electrochemically
mediated
reactions
