Synlett,
Journal Year:
2024,
Volume and Issue:
35(16), P. 1906 - 1908
Published: March 20, 2024
Abstract
An
attempted
aryl
selenium-catalyzed
formation
of
cis-chlorohydrins
from
alkenes
was
unsuccessful
but
led
to
an
electrochemical
investigation
for
the
trans-selective
chloroformyloxylation
cyclic
and
acyclic
in
moderate
good
yields.
Interestingly,
when
1,1-disubstituted
were
used,
corresponding
vinyl
chloride
derivatives
obtained,
application
1-phenylcyclohex-1-ene
allyl
derivative.
A
visible-light-mediated
chlorotrifluoromethylation
catalyzed
by
a
copper-based
photo-redox
catalyst
of
internal
alkenes
is
reported.
The
reaction
proceeds
with
complete
regioselectivity
under
mild
conditions
using
commercially
available
F3CSO2Cl
as
both
the
trifluoromethyl
and
chlorine
source,
leading
to
synthesis
added-value
chemicals
atom-economy.
vast
array
were
functionalized
in
decent
good
yields,
highlighting
great
tolerance
various
functional
groups.
radical
process
starting
from
single
electron
reduction
an
excited
copper
was
evidenced,
synthetic
utility
our
products
showcased
valuable
molecules
such
α-trifluoromethylated
amides,
α-trifluoromethylated-β-aminoamides,
alkenes.
In
addition,
library
evaluated
vitro
for
its
cytotoxicity
against
lung
carcinoma
(A549)
colorectal
adenocarcinoma
(DLD-1)
cell
lines,
antifungal
antibacterial
activities
C.
albicans,
E.
coli
S.
aureus
strains,
respectively.
Compounds
2a,
2m,
2n,
2o
demonstrated
anticancer
activities,
while
compounds
6g,
6h
exhibited
weak
underscoring
therapeutic
potential
this
class
suggesting
opportunities
further
optimization.
Science China Chemistry,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Dec. 12, 2022
Abstract
During
the
past
few
years,
electrochemical
oxidative
reactions
through
radical
intermediates
have
emerged
as
an
environmentally-benign,
powerful
platform
for
facile
formation
of
C–E
(E
=
C,
N,
S,
Se,
O
and
Hal)
bonds
single-electron-transfer
(SET)
processes
at
electrodes.
Functionalized
unsaturated
molecules
unusual
structural
motifs
can,
instance,
be
directly
constructed
under
exceedingly
mild
reaction
conditions
initial
attack
onto
alkynes.
This
minireview
highlights
recent
advances
in
electrooxidation
until
June
2022,
with
a
particular
focus
on
additions
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(14), P. 1599 - 1605
Published: March 13, 2024
Comprehensive
Summary
Functionalized
free
radical
addition/cyclization
reactions
represent
an
efficient
way
for
introducing
new
functionality
or
coupling
fragments
to
molecules.
Ynones
are
good
regional
selectivity
acceptors
in
organic
synthesis,
and
many
of
bio‐relevant
cyclic
compounds
could
be
easily
obtained
by
direct
cyclization
reaction.
Here,
we
report
a
photocatalytic
cascade
addition
biaryl
ynones,
the
divergent
synthesis
privileged
carbon
cycles.
Additionally,
further
transformation
multi‐functional
group
product
into
variety
other
derivatives
demonstrates
synthetic
value
this
developed
method.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(18), P. 5306 - 5324
Published: Jan. 1, 2024
This
review
summarizes
recent
achievements
in
electrosynthesis
of
organohalides
through
difunctionalization
alkenes
and
alkynes
provides
insights
into
future
directions
for
the
development
field.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(50), P. 9337 - 9341
Published: Dec. 14, 2022
An
unprecedented
electrochemical
three-component
reaction
of
phenylacetylene,
sulfinate,
and
N-(formyl)anilide
was
discovered.
The
transformation
occurs
in
an
undivided
cell
with
a
graphite
anode
cathode
DMF
the
presence
tetrabutylammonium
iodide
as
electrolyte.
addition
silver(I)
oxide
catalytic
amounts
iodine
facilitated
significantly.
also
carried
out
under
photoredox-catalyzed
conditions.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(16), P. 2741 - 2747
Published: July 4, 2022
Abstract
Iodohydrins
and
corresponding
ethers
were
synthesized
by
an
electrochemical
process
using
inexpensive
non‐toxic
ammonium
iodide.
This
transformation
was
applied
to
a
panel
of
alkenes,
giving
products
without
the
need
external
hazardous
oxidants,
reductants
or
metal
catalyst.
protocol
showed
general
efficiency
synthesize
valuable
iodinated
molecules
with
yields
from
19%
90%.
magnified
image
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(10)
Published: Aug. 16, 2023
Abstract
Conventional
methods
for
hydrogenation
of
organic
compounds
generally
use
corrosive
catalysts
and
reagents,
along
with
extreme
conditions
like
high
temperatures
pressures.
Quenching
materials
does
not
deter
its
negative
impact
on
the
environment,
nor
is
one
safe
when
it
comes
to
working
temperature
pressure.
Electrochemical
(ECH)
has
proven
be
green
since
most
efficient
reactions
are
conducted
at
ambient
pressure
temperature,
minimizing,
sometimes
even
negating
toxic
reagents
as
compared
conventional
methods.
This
review
therefore
provides
different
strategies
used
ECH
in
past,
modification
electrodes,
half
taken
up
energy
usage
reactions.
It
presents
advances
electrochemical
compounds,
starting
from
simple
aliphatic
complex
polyaromatics
heterocyclic
aromatic
compounds.
