Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(44), P. 9492 - 9497
Published: Oct. 30, 2024
Here
we
report
a
simultaneous
construction
of
two
C-C
and
C-N
bonds
in
unified
procedure
that
incorporates
alkynoic
acid
trifunctionalization,
ortho
C-H
functionalization,
amination
cascade.
In
an
ordered
process,
the
regioselective
alkyne
insertion
reaction
is
favored
over
decarboxylation
process.
The
presence
carboxyl
group
ensures
high
regioselectivity
carbopalladation
paving
way
for
novel
method
to
synthesize
unsymmetrically
2,3-diaryl
substituted
indole
scaffolds
with
excellent
regioselectivity.
protocol
demonstrated
be
suitable
gram-scale
synthesis.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 30, 2025
Mono-metallic
catalysts
dominate
in
homogeneous
catalysis,
wherein
all
the
element
steps
generally
occur
on
one
metal
site.
Inspired
from
bimetallic
active
sites
both
enzymes
and
heterogeneous
catalysts,
development
of
binuclear
catalysis
can
offer
potential
to
induce
novel
intermediates,
reactivity,
selectivity.
Metal-catalyzed
hydroarylation
alkynes
leads
alkyne
incorporated
products
dimerization-hydrocarbofunctionalization
is
rather
challenging
via
conventional
mono-metallic
intermediates.
Herein,
a
highly
selective
internal
achieved
dinickel
leading
formation
synthetically
pentasubstituted
1,3-dienes.
Mechanistic
studies
suggest
that
each
Ni
site
promote
distinct
elementary
two
generate
di-vinyl
di-Ni
intermediate.
Such
mode
"binuclear
convergent
catalysis"
fundamentally
different
traditional
may
provide
new
understanding
synergistic
effects
at
atomic
molecular
level.
Here
authors
report
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 14, 2025
Transition-metal-free
transformations
are
recognized
as
green
and
sustainable
methods
for
constructing
carbon-carbon
bonds
in
organic
synthesis.
This
review
describes
the
application
of
six
peroxides,
including
tert-butyl
hydroperoxide
(TBHP),
di-tert-butyl
peroxide
(DTBP),
peroxybenzoate
(TBPB),
benzoyl
(BPO),
dialauroyl
(DLP),
diguyl
(DCP),
C-C
bond
construction,
highlighting
selected
examples
mechanisms
challenging
transformations.
Each
section
concludes
with
a
detailed
overview
suitable
reagents
various
coupling
reactions
strengths
weaknesses
reported
works.
work
aims
to
inspire
further
innovations
transition-metal-free
oxidative
transformations,
promoting
eco-friendly
chemical
processes
paving
way
new
peroxide-based
synthesis
methods.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(7), P. 1551 - 1558
Published: Feb. 7, 2024
Abstract
The
alkyne
motif
is
present
in
several
naturally
occurring
molecules
and
specialty
chemicals.
Sonogashira
reaction
recognized
as
one
of
the
most
exploited
methods
for
synthesis
substituted
alkynes.
While
palladium
catalysts
have
been
traditionally
employed,
recent
efforts
directed
towards
developing
alternatives
based
on
Earth‐abundant
metals
such
nickel.
However,
nickel‐catalyzed
couplings
still
important
substrate
limitations.
more
reactive
aryl
iodides
well
documented,
coupling
challenging
yet
cost‐effective
bromides
chlorides
lags
significantly
behind.
Herein,
we
a
method
chlorides,
whose
discovery
was
accelerated
thanks
to
high‐throughput
experimentation.
Fine‐tuning
bipyridine
ligand
essential
activate
chemoselectively
C(
sp
2
)−Br
or
)−Cl
bonds.
A
wide
range
functionally
diverse
alkynes,
including
examples
active
ingredients
their
intermediates,
were
accessed
single
step
with
yields
up
98%.
developed
methodology
expected
be
widely
adopted
by
academia
industry,
marking
forward
field
base
metal
catalysis.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(13), P. 9395 - 9403
Published: March 18, 2024
Capitalizing
a
synergy
between
late-stage
C(sp3)–H
alkynylation
and
series
of
transition
metal-catalyzed
alkyne
functionalization
reactions,
we
reported
herein
enantioselective
divergent
synthesis
10
diterpenoid
pyrones
within
14–16
steps
starting
from
chiral
pool
enoxolone,
including
the
first
higginsianins
A,
B,
D,
E,
metarhizin
C.
Our
also
highlights
an
unprecedented
biomimetic
oxidative
rearrangement
α-pyrone
into
3(2H)-furanone,
as
well
applications
Echavarren
reaction
Toste
counterion-mediated
Au-catalyzed
intramolecular
allene
hydroalkoxylation
in
natural
product
synthesis.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(25), P. 5052 - 5086
Published: Jan. 1, 2024
1,2/1,1-Difunctionalization
of
alkynes
(cascade
C–C
and
C–O
bond
formations)
serves
as
one
the
reliable
methods
for
synthesis
numerous
chemical
architectures.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(15)
Published: June 3, 2024
Abstract
Polymers
with
well‐defined
structures,
synthesized
through
metal‐catalyzed
processes,
and
having
end
groups
exhibiting
different
polarity
reactivity
than
the
backbone,
are
gaining
considerable
attention
in
both
scientific
industrial
communities.
These
polymers
show
potential
applications
as
fundamental
building
blocks
additives
creation
of
innovative
functional
materials.
Investigations
directed
toward
identifying
most
optimal
uncomplicated
synthetic
approach
by
employing
a
combination
living
coordination
polymerization
mediated
rare‐earth
metal
complexes
C–H
bond
activation
reaction
σ‐bond
metathesis.
This
directly
yields
catalysts
diverse
from
single
precursor,
enabling
production
terminal‐functionalized
without
need
for
sequential
reactions,
such
termination
reactions.
The
utilization
this
methodology
allows
precise
control
over
end‐group
functionalities,
providing
versatile
to
tailor
properties
resulting
polymers.
perspective
discusses
principles,
challenges,
advancements
associated
strategy,
highlighting
its
significance
advancing
interface
metalorganic
chemistry,
polymer
materials
science.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Herein,
an
overview
of
the
evolution
electrochemical
C–H
annulations
with
alkynes
for
construction
heterocycles
is
provided,
a
topical
focus
on
underlying
mechanism
manifolds.
Synthesis,
Journal Year:
2023,
Volume and Issue:
56(12), P. 1862 - 1872
Published: Dec. 14, 2023
Abstract
The
construction
of
axially
chiral
alkene
frameworks
is
currently
one
hottest
topics
in
the
field
organic
synthetic
chemistry.
Compared
to
traditional
molecules,
such
as
biaryls,
heterobiaryls,
and
anilides,
synthesis
alkenes
far
more
challenging,
especially
for
acyclic
tetrasubstituted
analogues.
In
this
review,
we
summarized
development
strategies
analogues,
including
asymmetric
difunctionalization,
C–H
functionalization,
cross-coupling,
(dynamic)
kinetic
resolution,
allylic
substitution-isomerization.
1
Introduction
2
Synthesis
Cyclic
Tetrasubstituted
Axially
Chiral
Alkenes
3
Acyclic
4
Summary
Outlook
