Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(5)
Published: March 15, 2024
This
research
introduces
an
eco‐friendly
and
innovative
technique
for
efficiently
producing
p‐tolylmethanol
derivatives
4(a–k)
using
electro‐organic
synthesis
based
on
the
Grignard
reaction.
By
employing
electrochemical
methods,
this
approach
offers
several
advantages,
including
enhanced
reaction
efficiency
reduced
environmental
impact.
The
process
involves
generation
of
reagent,
followed
by
its
with
appropriate
substrates
to
yield
desired
derivatives.
Our
team
optimized
various
parameters
like
choice
solvent,
electrode
material,
conditions
achieve
high
yields
selectivity.
developed
method
demonstrated
outstanding
presents
a
fresh
environmentally
conscious
synthesizing
from
benzaldehyde
1(a–e)
bromobenzene
2(a–h)
via
reaction,
yielding
excellent
results
(85–93%).
resulting
compounds
were
comprehensively
characterized
melting
point,
1
H
NMR
spectroscopy,
CHN
analysis
verify
their
structures.
holds
significant
potential
as
sustainable
strategy
valuable
organic
compounds.
RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
15(1), P. 10 - 54
Published: Oct. 20, 2023
Many
researchers
around
the
world
are
working
on
development
of
novel
anticancer
drugs
with
different
mechanisms
action.
In
this
case,
coumarin
is
a
highly
promising
pharmacophore
for
drugs.
Besides,
hybridization
moiety
other
pharmacophores
has
emerged
as
potent
breakthrough
in
treatment
cancer
to
decrease
its
side
effects
and
increase
efficiency.
This
review
aims
provide
comprehensive
overview
recent
derivatives
their
application
Herein,
we
highlight
describe
largest
number
research
works
reported
field
from
2015
August
2023,
along
action
structure-activity
relationship
studies,
making
articles
published
topic
date.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(8), P. 5547 - 5565
Published: Jan. 1, 2024
Spiro
heterocycle
frameworks
are
a
class
of
organic
compounds
that
possesses
unique
structural
features
making
them
highly
sought-after
targets
in
drug
discovery
due
to
their
diverse
biological
and
pharmacological
activities.
ChemistryOpen,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
Heterocycles
are
a
vital
class
of
compounds
in
numerous
fields,
including
drug
discovery,
agriculture,
and
materials
science.
Efficient
methods
for
the
synthesis
heterocycles
remain
critical
meeting
demands
these
industries.
Recent
advances
multicomponent
reactions
(MCRs)
utilizing
2‐aminobenzothiazole
(ABT)
have
shown
promising
results
formation
heterocycles.
The
versatility
this
context
has
enabled
rapid
efficient
construction
diverse
heterocyclic
structures.
Various
synthetic
methodologies
involving
discussed,
highlighting
its
importance
as
valuable
building
block
complex
potential
applications
discovery
material
science
also
explored.
Overall,
review
provides
comprehensive
overview
current
state
research
field
offers
insights
into
future
directions
area
study.
We
highlight
ABT
versatile
sustainable
starting
via
MCRs,
with
significant
implications
chemical
industry.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(30)
Published: Aug. 6, 2024
Abstract
This
review
provides
an
overview
of
the
recent
advances
in
synthesis
diverse
heterocyclic
compounds
using
thiosemicarbazide
as
a
key
building
block
via
multicomponent
reactions.
Thiosemicarbazide
is
versatile
reagent
that
has
gained
significant
attention
organic
due
to
its
ability
participate
reactions
for
efficient
and
sustainable
construction
assembly
novel
bioactive
molecules
pharmaceuticals.
discusses
potential
applications
future
directions
this
rapidly
evolving
area
research.
It
valuable
insights
into
innovative
approaches
heterocycles
thiosemicarbazide,
showcasing
significance
modern
chemistry
In
summary,
current
state
art,
highlighting
use
reported
between
2015
early
2024.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(5), P. 3928 - 3953
Published: Jan. 1, 2025
This
review
studies
magnetically
recoverable
catalysts
designed
for
the
efficient
multicomponent
synthesis
of
organosulfur
compounds.
These
enhance
process
by
combining
efficiency
with
environmental
sustainability.
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
13
Published: March 3, 2025
In
the
last
10
years,
synthesis
of
anthracene
scaffolds
has
attracted
considerable
interest
because
their
distinctive
electronic
characteristics
and
various
uses
in
organic
electronics,
photovoltaics,
therapeutics.
Anthracene,
a
polycyclic
aromatic
hydrocarbon,
is
valued
for
its
lightweight,
stability,
electron
transport
capabilities,
making
it
key
building
block
advanced
materials.
Traditional
methods
often
face
challenges
such
as
low
selectivity
harsh
conditions.
However,
recent
advancements
transition
metal-catalyzed
reactions
have
transformed
field,
offering
more
efficient
versatile
approaches.
This
review
examines
methodologies
utilizing
metal
catalysts
like
palladium,
zinc,
indium,
cobalt,
gold,
iridium,
rhodium
ruthenium,
which
enabled
novel
synthetic
pathways
selective
formation
substituted
anthracenes
through
cross-coupling
reactions.
The
function
ligands,
including
phosphines
N-heterocyclic
carbenes,
improving
reaction
efficiency
also
examined.
shift
towards
greener
noted,
with
focus
on
minimizing
waste
reducing
toxic
reagents.
Several
case
studies
demonstrate
successful
application
these
techniques,
highlighting
structural
diversity
functional
potential
derivatives
applications.
This
review
highlights
the
recent
advances
in
multi-component
reactions
for
synthesizing
heterocyclic
compounds
via
green
approaches
including
photoredox
catalysis,
electrochemical
activation,
catalyst-free
methods
and
use
of
water
as
sole
solvent.
