Transcriptomic Vascular and Endothelial Changes in Experimental Periodontitis in Nonhuman Primates DOI
Linh M. Nguyen, Octavio A. González,

Axel Balian

et al.

Oral Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

ABSTRACT Objective The molecular features of the alterations in integrity and function periodontal vasculature associated with initiation/progression lesions have not been well elucidated. Methods This study used a nonhuman primate model experimental ligature‐induced periodontitis across lifespan to profile transcriptomic responses related vasculature/endothelial cell biologic activities. Results In healthy tissues, genes representing EGF receptor signaling, VEGF angiogenesis pathways showed some age effects. Disease initiation and/or early progression led major changes expression large number vascular/endothelial correlations groups. Specific bacteria (e.g., Veillonellacease , P. gingivalis Fusobacterium ) were highly correlated gene CCL2, CXCL1, EDN2, OCLN, PLAT, SELL, TGFB2). Overall differential analytics identified that disease process appeared as controlling factor regarding transcriptome. Conclusions supports processes are observed tissues lifespan, more substantive occurring during progression. patterns supported critical arising gingival would contribute persistent nature immunoinflammatory response this disease.

Language: Английский

Comparative approaches and insights into animal models of periodontitis DOI

Jaemin Joun,

Zhao Wang, Ju Han Song

et al.

International Journal of Oral Biology, Journal Year: 2025, Volume and Issue: 50(1), P. 8 - 16

Published: March 30, 2025

Language: Английский

Citations

0
Transcriptomic Vascular and Endothelial Changes in Experimental Periodontitis in Nonhuman Primates DOI
Linh M. Nguyen, Octavio A. González,

Axel Balian

et al.

Oral Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

ABSTRACT Objective The molecular features of the alterations in integrity and function periodontal vasculature associated with initiation/progression lesions have not been well elucidated. Methods This study used a nonhuman primate model experimental ligature‐induced periodontitis across lifespan to profile transcriptomic responses related vasculature/endothelial cell biologic activities. Results In healthy tissues, genes representing EGF receptor signaling, VEGF angiogenesis pathways showed some age effects. Disease initiation and/or early progression led major changes expression large number vascular/endothelial correlations groups. Specific bacteria (e.g., Veillonellacease , P. gingivalis Fusobacterium ) were highly correlated gene CCL2, CXCL1, EDN2, OCLN, PLAT, SELL, TGFB2). Overall differential analytics identified that disease process appeared as controlling factor regarding transcriptome. Conclusions supports processes are observed tissues lifespan, more substantive occurring during progression. patterns supported critical arising gingival would contribute persistent nature immunoinflammatory response this disease.

Language: Английский

Citations

0