Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves

BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e069503 - e069503

Published: July 27, 2022

To clarify in patients with covid-19 the recovery rate of smell and taste, proportion persistent dysfunction prognostic factors associated taste.

Language: Английский

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Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019

The Journal of Infectious Diseases, Journal Year: 2022, Volume and Issue: 226(8), P. 1304 - 1308

Published: March 25, 2022

The omicron variant of severe acute respiratory syndrome coronavirus 2 causes much less olfactory dysfunction than the previous variants. There are several potential mechanisms for how may change tissue tropism and spare function. new mutations make more hydrophobic alkaline variants, which reduce penetration mucus layer. Overall, minimally receptor binding affinity, but entry efficiency into host cells is reduced in expressing transmembrane serine protease (TMPRSS2). Because support epithelium abundantly express TMPRSS2, these main target become infected by variant.

Language: Английский

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RETRACTED AND REPLACED: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

Chemical Senses, Journal Year: 2022, Volume and Issue: 47

Published: Jan. 1, 2022

Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because before was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate patients, we conducted a systematic review meta-analysis 376 papers published 2020-2021, 241 meeting all inclusion criteria. Drawing on previous studies guided by early meta-analyses, explored how methodological differences (direct vs. self-report measures) may affect these estimates. We hypothesized direct measures at least as sensitive those obtained preponderance evidence confirms is symptom COVID-19. The showed that, among 138,897 COVID-19-positive 39.2% reported dysfunction (95% confidence interval: 35.34%-43.12%), estimates were slightly but not significantly higher from using (n = 18) versus 223) methodologies (Q 0.57, df 1, P 0.45). Generally, males lower rates than did females, highest middle-aged adults. Thus, likely bona fide COVID-19, meriting further research into most appropriate methods measure it its underlying mechanisms.

Language: Английский

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Prevalence of Olfactory Dysfunction with the Omicron Variant of SARS-CoV-2: A Systematic Review and Meta-Analysis

Cells, Journal Year: 2023, Volume and Issue: 12(3), P. 430 - 430

Published: Jan. 28, 2023

The omicron variant is thought to cause less olfactory dysfunction than previous variants of SARS-CoV-2, but the reported prevalence differs greatly between populations and studies. Our systematic review meta-analysis provide information regarding regional differences in as well an estimate global based on 62 studies reporting 626,035 patients infected with variant. omicron-induced European ancestry 11.7%, while it significantly lower all other populations, ranging 1.9% 4.9%. When ethnic population sizes are considered, adults estimated be 3.7%. Omicron's effect olfaction twofold tenfold that alpha or delta according meta-analyses our analysis directly compared variants. profile ethnicities mirrors results a recent genome-wide association study connected gene locus encoding odorant-metabolizing enzyme, UDP glycosyltransferase, extent COVID-19-related loss smell. consistent hypothesis this enzyme contributes observed differences.

Language: Английский

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Psychophysical assessment of olfactory and gustatory function in post‐mild COVID‐19 patients: A matched case‐control study with 2‐year follow‐up

International Forum of Allergy & Rhinology, Journal Year: 2023, Volume and Issue: 13(10), P. 1864 - 1875

Published: March 5, 2023

The aim of this study was to psychophysically evaluate the prevalence smell and taste dysfunction 2 years after mildly symptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection compared that observed at 1-year follow-up while considering background chemosensory in no-coronavirus disease 2019 (COVID-19) population.This is a prospective case-control on 93 patients with polymerase chain reaction (PCR)-positive SARS-CoV-2 matched controls. Self-reported olfactory gustatory assessed by 22-item Sino-Nasal-Outcome Test (SNOT-22), item "Sense or taste." Psychophysical orthonasal retronasal function performance were estimated using extended Sniffin' Sticks test battery, 20 powdered tasteless aromas, strips test, respectively. Nasal trigeminal sensitivity sniffing 70% solution acetic acid.The two psychophysical assessments took place median 409 days (range, 366-461 days) 765 739-800 from first SARS-CoV-2-positive swab, At 2-year follow-up, cases exhibited decrease (27.9% vs. 42.0%; absolute difference, -14.0%; 95% confidence interval [CI], -21.8% -2.6%; p = 0.016) (14.0% 25.8%; -11.8%; CI, -24.2% 0.6%; 0.098). Subjects prior COVID-19 more likely than controls have an 10.8 %; 17.2%; 5.2% 28.8%) but not 9.7%; 4.3%; -5.8% 14.4% 0.496) still infection. Overall, 3.2% anosmic infection.Although proportion subjects recovered long-lasting smell/taste 1 year COVID-19, significant excess when

Language: Английский

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The taste of the pandemic—contemporary review on the current state of research on gustation in coronavirus disease 2019 (COVID‐19)

International Forum of Allergy & Rhinology, Journal Year: 2021, Volume and Issue: 12(2), P. 210 - 216

Published: Oct. 26, 2021

Subjectively perceived impairment of taste is a common and distinct symptom coronavirus disease 2019 (COVID-19). Large meta-analyses identified this in approximately 50% cases. However, high prevalence not supported by blinded validated psychophysical gustatory testing, which showed much lower up to 26% patients. This discrepancy may be due misinterpretation impaired retronasal olfaction as dysfunction. In addition, we hypothesized that COVID-19-associated hyposmia involved the decrease function, found for different origin. indirect mechanism would based on central-nervous mutual amplification between chemical senses, fails olfactory loss. further research necessary how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) directly impair pathway well its subjective perception.

Language: Английский

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Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

Chemical Senses, Journal Year: 2023, Volume and Issue: 48

Published: Jan. 1, 2023

Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because before was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate patients, we conducted a systematic review meta-analysis 376 papers published 2020-2021, 235 meeting all inclusion criteria. Drawing on previous studies guided by early meta-analyses, explored how methodological differences (direct vs. self-report measures) may affect these estimates. We hypothesized direct measures at least as sensitive those obtained preponderance evidence confirms is symptom COVID-19. The showed that, among 138,015 COVID-19-positive 36.62% reported dysfunction (95% confidence interval: 33.02%-40.39%), estimates were slightly but not significantly higher from using (n = 15) versus 220) methodologies (Q 1.73, df 1, P 0.1889). Generally, males lower rates than did females, highest middle-aged adults. Thus, likely bona fide COVID-19, meriting further research into most appropriate methods measure it its underlying mechanisms.

Language: Английский

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Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: Results from chemosensitive testing eight months after the acute infection

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(3), P. e0265686 - e0265686

Published: March 23, 2022

Olfactory and gustatory disorders are prominent symptoms of acute COVID-19. Although both senses recover in many patients within weeks to months, persistency has been described up 60%. However now most reports on the course chemosensitive after COVID-19 not based psychophysical testing but only subjective patients’ ratings. In this study we assessed olfaction gustation using tests eight months Validated revealed hyposmia 18% hypogeusia even 32% 303 included patients. This shows that olfactory especially have be seen as important chronic post-COVID-19. The high prevalence dysfunction indicates function does or might deteriorate following infection.

Language: Английский

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Recommendation for standardized medical care for children and adolescents with long COVID

Monatsschrift Kinderheilkunde, Journal Year: 2022, Volume and Issue: 170(6), P. 539 - 547

Published: May 25, 2022

Zusammenfassung Das vorliegende Konsensuspapier bietet in Ergänzung zur AWMF-S1-Leitlinie eine Übersicht über die verschiedenen klinischen Aspekte von Long COVID im Kindes- und Jugendalter. Es wurde Vertreter:innen aus 19 Fachgesellschaften des DGKJ-Konvents kooperierenden erstellt Expertenempfehlungen für Praxis auf Grundlage der bisherigen, noch geringen studienbasierten Evidenz zu enthält Screeningfragen sowie einen Vorschlag strukturierten, standardisierten pädiatrischen Anamnese diagnostischen Evaluation bei V. a. . Dazu werden ein zeit- ressourcensparender Erfassungsbogen, Komplexität Krankheitsbildes berücksichtigt, Internetseiten DGKJ DGPI Verfügung gestellt weitere Fragebögen Abklärung spezifischen neurokognitiven und/oder psychischen Störungen post-exertioneller Malaise (PEM) myalgischer Enzephalomyelitis/chronischem Fatigue-Syndrom (ME/CFS) benannt. Anhand jeweiligen anamnestisch klinisch ermittelten Hauptsymptome gestuftes, diagnostisches Vorgehen multidisziplinäre Betreuung empfohlen.

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Results from psychophysical tests of smell and taste during the course of SARS-CoV-2 infection: a review

Acta Otorhinolaryngologica Italica, Journal Year: 2022, Volume and Issue: 42(2 (Suppl.1)), P. S20 - S35

Published: April 1, 2022

Only a few studies have assessed smell and taste in Coronavirus Disease 2019 (COVID-19) patients with psychophysical tests, while the majority performed self-rating evaluations. Given heterogeneity of published literature, aim this review was to systemati- cally analyse articles on topic focus testing. A search PubMed Web Science from December 2019, November 2021, cross-refer- ences, executed. The main eligibility criteria were English-language articles, investi- gating clinical features olfaction gustation COVID-19 using self-rat- ing assessment, testing imaging techniques. total 638 identified 66 included. Self-rating assessment 31 studies, 30 techniques 5. prevalence chemosensory dysfunction most investigated topic, followed by recovery time. About psy- chophysical extended version Sniffin’ Sticks used 11 Connecticut Chemosensory Clinical Research Center test another 11. olfac- tory threshold performance impacted compared discrimination identification capacities accordance hypothesis tropism SARS-CoV-2 for olfactory mucosa. timing significantly influenced results 20% presenting at one month after infection.

Language: Английский

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