Detecting Early Cognitive Decline in Alzheimer’s Disease with Brain Synaptic Structural and Functional Evaluation DOI Creative Commons
Samo Ribarič

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 355 - 355

Published: Jan. 26, 2023

Early cognitive decline in patients with Alzheimer's (AD) is associated quantifiable structural and functional connectivity changes the brain. AD dysregulation of Aβ tau metabolism progressively disrupt normal synaptic function, leading to loss synapses, decreased hippocampal density early atrophy. Advances brain imaging techniques living have enabled transition from clinical signs symptoms-based diagnosis biomarkers-based diagnosis, techniques, quantitative EEG, body fluids sampling. The hippocampus has a central role semantic episodic memory processing. This function critically dependent on intrahippocampal connections many cortical regions, including perirhinal entorhinal cortex, parahippocampal association regions temporal parietal lobes, prefrontal cortex. Therefore, reflected altered intrinsic networks (aka large-scale networks), memory, default mode, salience networks. narrative review discusses recent critical issues related detecting AD-associated markers high-risk or neuropsychologically diagnosed subjective impairment mild impairment.

Language: Английский

Smart Materials Enabled with Artificial Intelligence for Healthcare Wearables DOI
Youbin Zheng, Ning Tang, Rawan Omar

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(51)

Published: Aug. 12, 2021

Abstract Contemporary medicine suffers from many shortcomings in terms of successful disease diagnosis and treatment, both which rely on detection capacity timing. The lack effective, reliable, affordable real‐time monitoring limits the affordability timely treatment. A new frontier that overcomes these challenges relies smart health systems combine wearable sensors an analytical modulus. This review presents latest advances materials for development multifunctional while providing a bird's eye‐view their characteristics, functions, applications. also state‐of‐the‐art wearables fitted with artificial intelligence (AI) support clinical decision early accurate disorders. ongoing future prospects personal healthcare AI‐assisted relating to decisions are presented discussed.

Language: Английский

Citations

99
Exosomes: Potential Disease Biomarkers and New Therapeutic Targets DOI Creative Commons
María Isabel Mosquera Heredia, Luis Carlos Morales, Oscar M. Vidal

et al.

Biomedicines, Journal Year: 2021, Volume and Issue: 9(8), P. 1061 - 1061

Published: Aug. 20, 2021

Exosomes are extracellular vesicles released by cells, both constitutively and after cell activation, present in different types of biological fluid. involved the pathogenesis diseases, such as cancer, neurodegenerative pregnancy disorders cardiovascular have emerged potential non-invasive biomarkers for detection, prognosis therapeutics a myriad diseases. In this review, we describe recent advances related to regulatory mechanisms exosome biogenesis, release molecular composition, well their role health disease, use disease therapeutic targets. addition, advantages disadvantages main isolation methods, characterization cargo analysis, experimental methods used exosome-mediated drug delivery, discussed. Finally, perspectives exosomes future clinical practice.

Language: Английский

Citations

97
Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics DOI Open Access

Hagar M. Soliman,

Ghada A. Ghonaim,

Shaza M. Gharib

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10794 - 10794

Published: Oct. 6, 2021

Exosomes (EXOs) were given attention as an extracellular vesicle (EV) with a pivotal pathophysiological role in the development of certain neurodegenerative disorders (NDD), such Parkinson's and Alzheimer's disease (AD). EXOs have shown potential to carry pathological therapeutic cargo; thus, researchers harnessed drug delivery applications. low immunogenicity natural vehicles, thus ensuring efficient without causing significant adverse reactions. Recently, provided opportunities AD promising future clinical applications diagnosis NDD studied for their usefulness detection prediction prior emergence symptoms. In future, microfluidics technique will play essential isolating detecting diagnose before advanced This review is not reiterative literature but discuss why strong treating how they can be used tool predict this disorder.

Language: Английский

Citations

58
A combination model of AD biomarkers revealed by machine learning precisely predicts Alzheimer's dementia: China Aging and Neurodegenerative Initiative (CANDI) study DOI
Feng Gao,

Xinyi Lv,

Linbin Dai

et al.

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 19(3), P. 749 - 760

Published: June 6, 2022

To test the utility of "A/T/N" system in Chinese population, we study core Alzheimer's disease (AD) biomarkers a newly established cohort.

Language: Английский

Citations

54
Current trends in blood biomarker detection and imaging for Alzheimer’s disease DOI
Shun Hu, Changwen Yang, Haiming Luo

et al.

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 210, P. 114278 - 114278

Published: April 13, 2022

Language: Английский

Citations

52
Multipronged diagnostic and therapeutic strategies for Alzheimer's disease DOI Creative Commons
Madhu Ramesh, Thimmaiah Govindaraju

Chemical Science, Journal Year: 2022, Volume and Issue: 13(46), P. 13657 - 13689

Published: Jan. 1, 2022

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and major contributor to dementia cases worldwide. AD clinically characterized by learning, memory, cognitive deficits. The accumulation of extracellular amyloid β (Aβ) plaques neurofibrillary tangles (NFTs) tau are the pathological hallmarks explored as targets for clinical diagnosis therapy. pathology poorly understood there no fully approved treatments. Notwithstanding gap, decades research in understanding mechanisms have revealed multifactorial nature AD. As result, multipronged holistic approaches pertinent targeting multiple biomarkers developing effective therapeutics. In this perspective, recent developments Aβ targeted diagnostic therapeutic tools discussed. Novel indirect, combination, circulating potential highlighted. We underline importance multiplexing multimodal detection generate biomarker fingerprints reliable strategy. classical therapeutics aggregation pathways described with bottlenecks Drug discovery efforts multifaceted toxicity involving protein aggregation, metal toxicity, oxidative stress, mitochondrial damage, neuroinflammation Recent focused on strategies rationally design multifunctional modulators factors presented future drug development discover

Language: Английский

Citations

52
Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer’s disease: a meta-analysis and systematic review DOI Creative Commons
Lidian Chen, Weilin Liu, Huawei Lin

et al.

Neural Regeneration Research, Journal Year: 2022, Volume and Issue: 17(11), P. 2381 - 2381

Published: Jan. 1, 2022

Blood exosomes, which are extracellular vesicles secreted by living cells into the circulating blood, regarded as a relatively noninvasive novel tool for monitoring brain physiology and disease states. An increasing number of blood cargo-loaded exosomes emerging potential biomarkers preclinical clinical Alzheimer's disease. Therefore, we conducted meta-analysis systematic review molecular derived from to comprehensively analyze their diagnostic performance in disease, mild cognitive impairment, We performed literature search PubMed, Web Science, Embase, Cochrane Library inception August 15, 2020. The research subjects mainly included identified 34 observational studies, 15 were quantitative analysis (Newcastle-Ottawa Scale score 5.87 points) 19 used qualitative analysis. results showed that core including Aβ1–42, P-T181-tau, P-S396-tau, T-tau increased neuron-derived patients. Molecules related additional risk factors involved neuroinflammation (C1q), metabolism disorder (P-S312-IRS-1), neurotrophic deficiency (HGF), vascular injury (VEGF-D), autophagy-lysosomal system dysfunction (cathepsin D) also increased. At gene level, differential expression transcription-related (REST) microRNAs (miR-132) affects RNA splicing, transport, translation. These pathological changes contribute neural loss synaptic dysfunction. data confirm above-mentioned molecules risk-related can serve candidate findings support further development exosome test This was registered at International Prospective Register Systematic Reviews (Registration No. CRD4200173498, 28/04/2020).

Language: Английский

Citations

48
Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease DOI Creative Commons
Huimin Cai,

Yana Pang,

Qi Wang

et al.

Alzheimer s Research & Therapy, Journal Year: 2022, Volume and Issue: 14(1)

Published: Dec. 5, 2022

Neuronal- and astrocyte-derived exosomes have been identified as an optimal source for screening biomarkers Alzheimer's disease (AD). However, few studies focus on the bulk exosome population isolated from plasma of AD. This study investigated whether proteins in can aid diagnosis AD.The were collected by ultracentrifuge. Protein samples extracted exosomes. Cerebrospinal fluid levels amyloid β (Aβ)42 phosphorylated tau (P-tau)181 measured diagnostic purposes. A pilot (controls, 20; AD, 20) followed a second dataset 56; 58) was used to establish model Mass spectrometry-based proteomics performed profile exosomal proteome. Parallel reaction monitoring further confirm differentially expressed proteins.In total, 328 quantified. Among them, 31 altered AD patients, 12 validated. The receiver operating characteristic curve analysis revealed combination six (upregulated: Ig-like domain-containing protein (A0A0G2JRQ6), complement C1q subcomponent subunit C (C1QC), component C9 (CO9), platelet glycoprotein Ib beta chain (GP1BB), Ras suppressor 1 (RSU1); downregulated: disintegrin metalloproteinase domain 10 (ADA10)) has capacity differentiate patients healthy controls with high accuracy. Linear correlation showed that significantly correlated cognitive performance.The A0A0G2JRQ6, C1QC, CO9, GP1BB, RSU1, ADA10 acts novel candidate biomarker individuals.

Language: Английский

Citations

46
Biofluid Biomarkers of Alzheimer’s Disease: Progress, Problems, and Perspectives DOI Creative Commons
Shan Huang, Yan‐Jiang Wang, Junhong Guo

et al.

Neuroscience Bulletin, Journal Year: 2022, Volume and Issue: 38(6), P. 677 - 691

Published: March 19, 2022

Abstract Since the establishment of biomarker-based A-T-N (Amyloid/Tau/Neurodegeneration) framework in Alzheimer’s disease (AD), diagnosis AD has become more precise, and cerebrospinal fluid tests positron emission tomography examinations based on this have widely accepted. However, does not encompass whole spectrum pathologies, problems with invasiveness high cost limit application above diagnostic methods aimed at central nervous system. Therefore, we suggest addition an “X” to a focus peripheral biomarkers AD. In review, retrospectively describe recent progress A-T-N-X framework, analyze problems, present our perspectives

Language: Английский

Citations

44
The Roles of Exosomal Proteins: Classification, Function, and Applications DOI Open Access
Xinxin Li,

Lu-Xuan Yang,

Chuang Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3061 - 3061

Published: Feb. 4, 2023

Exosome, a subpopulation of extracellular vesicles, plays diverse roles in various biological processes. As one the most abundant components exosomes, exosomal proteins have been revealed to participate development many diseases, such as carcinoma, sarcoma, melanoma, neurological disorders, immune responses, cardiovascular and infection. Thus, understanding functions mechanisms potentially assists clinical diagnosis targeted delivery therapies. However, current knowledge about function application is still limited. In this review, we summarize classification proteins, exosome biogenesis disease development, well applications.

Language: Английский

Citations

40