Impact of exosomes in oral lichen planus: A review with insights into pathogenesis and biomarkers DOI Creative Commons
Ram Mohan Ram Kumar, Suresh Joghee,

Mahesh KP

et al.

Journal of Dental Sciences, Journal Year: 2024, Volume and Issue: 19(3), P. 1320 - 1327

Published: May 18, 2024

Oral Lichen Planus (OLP) presents a significant challenge in diagnosis due to its varied clinical manifestations and the absence of specific biomarkers. Timely accurate is crucial, particularly given association with oral squamous cell carcinoma (OSCC). This review aims explore potential role exosomes, small extracellular vesicles, pathogenesis OLP their utility as diagnostic Exosomes facilitate exchange information between cells modulate immune responses by carrying various bioactive molecules such proteins, lipids, nucleic acids. In context OLP, exosomes derived from affected tissues or are thought contribute disease progression mediating transfer pro-inflammatory molecules, including cytokines like interleukin-6 tumour necrosis factor-alpha chemokines CCL2, CCL5 microRNAs miR-155, miR-146a, miR-21, miR-34a, etc. Additionally, distinct molecular contents lesions may accurately represent pathological changes occurring these tissues. suggests be used non-invasive biomarkers for diagnosing tracking disease. Understanding microenvironment within this critical advancing our knowledge identifying new therapeutic strategies. However, challenges remain characterising translation. Further research warranted address fully exploit exosomes' other inflammatory diseases.

Language: Английский

Environmental pollutants and exosomes: A new paradigm in environmental health and disease DOI
Afsaneh Javdani-Mallak,

Iman Salahshoori

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171774 - 171774

Published: March 18, 2024

Language: Английский

Citations

15
Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine DOI Creative Commons

Lulu Meng,

Chao Zhang,

Pei Yu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107179 - 107179

Published: April 13, 2024

Exosomes, small yet vital extracellular vesicles, play an integral role in intercellular communication. They transport critical components, such as proteins, lipid bilayers, DNA, RNA, and glycans, to target cells. These vesicles are crucial modulating the matrix orchestrating signal transduction processes. In oncology, exosomes pivotal tumor growth, metastasis, drug resistance, immune modulation within microenvironment. Exosomal noted for their stability specificity, have garnered widespread attention. This review delves into mechanisms of exosomal protein loading impact on development, with a focus regulatory effects natural products traditional Chinese medicine function. insights not only offer new strategies methodologies cancer treatment but also provide scientific bases directions future clinical applications.

Language: Английский

Citations

6
Dual Role of Exosome in Neurodegenerative Diseases: A Review Study DOI
Mohsen Sheykhhasan, Fatemeh Heidari, Mohsen Eslami Farsani

et al.

Current Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 19(6), P. 852 - 864

Published: July 27, 2023

Extracellular vesicles (EVs) are one of the crucial means intercellular communication, which takes many different forms. They heterogeneous, secreted by a range cell types, and can be generally classified into microvesicles exosomes depending on their location function. Exosomes small EVs with diameters about 30-150 nm diverse sources.

Language: Английский

Citations

14
Impact of exosome therapy on pancreatic cancer and its progression DOI Creative Commons
Mohamed El‐Tanani, Hamdi Nsairat, Ismail Matalka

et al.

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(8)

Published: July 5, 2023

Abstract Pancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because low rates early identification, fast progression, difficulties following surgery, and ineffectiveness current oncologic therapies. There are no imaging techniques or biomarkers that can accurately identify, categorize, predict biological behavior this tumor. Exosomes extracellular vesicles play crucial rule in metastasis, chemoresistance pancreatic cancer. They have been verified to be potential for cancer management. Studying role exosomes is substantial. secreted by eukaryotic cells participated intercellular communication. The components exosomes, including proteins, DNA, mRNA, microRNA, long non-coding RNA, circular etc., regulating tumor growth, angiogenesis process development, used as prognostic marker and/or grading basis patients. Hereby, concise review, we intend summarize isolation, exosome secretion, function, importance progression exosomal miRNAs possible biomarkers. Finally, application treatment , which provides theoretical supports using serve precise clinic, will discussed.

Language: Английский

Citations

13
Identification of exosome-related gene signature as a promising diagnostic and therapeutic tool for breast cancer DOI Creative Commons
Qitong Chen, Qin Zhou

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29551 - e29551

Published: April 1, 2024

Exosomes are promising tools for the development of new diagnostic and therapeutic approaches. possess ability to activate signaling pathways that contribute remodeling tumor microenvironment, angiogenesis, regulation immune responses. We aimed develop a prognostic score based on exosomes derived from breast cancer.

Language: Английский

Citations

5
Magnetic lanthanide sensor with self-ratiometric time-resolved luminescence for accurate detection of epithelial cancerous exosomes DOI
Yating Zeng,

Xuekang Wang,

Nanhang Zhu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(29), P. 7203 - 7214

Published: Jan. 1, 2024

Fluorescence-based LB (liquid biopsy) offers a rapid means of detecting cancer non-invasively. However, the widespread issue sample loss during purification steps will diminish accuracy detection results. Therefore, in this study, we introduce magnetic lanthanide sensor (MLS) designed for sensitive characteristic protein, epithelial cell adhesion molecule (EpCAM), on tumor exosomes. By leveraging inherent multi-peak emission and time-resolved properties sole-component element, combined with self-ratiometric strategy, MLS can overcome limitations imposed by manual operation and/or complexity, thereby providing more stable reliable output Specifically, terbium-doped NaYF4 nanoparticles (NaYF4:Tb) deformable aptamers terminated BHQ1 were sequentially introduced onto superparamagnetic silica-decorated Fe3O4 nanoparticles. Prior to target binding, from NaYF4:Tb at 543 nm was partially quenched due fluorescence resonance energy transfer (FRET) BHQ1. Upon changes secondary structure led intensity increasing since deconfinement distance-dependent FRET effect. The then utilized as signal (I1), while less changed 583 served reference (I2), further reporting values I1 I2 (I1/I2) illustrate cancerous features exosomes ignoring possible loss. Consequently, over wide range exosome concentrations (2.28 × 102-2.28 108 particles per mL), I1/I2 ratio exhibited linear increase concentration [Y(I1/I2) = 0.166 lg (Nexosomes) + 3.0269, R2 0.9915], achieving theoretical limit low 24 mL. Additionally, effectively distinguished samples healthy samples, showcasing significant potential clinical diagnosis.

Language: Английский

Citations

5
Multi-omics analysis identified extracellular vesicles as biomarkers for cardiovascular diseases DOI
Meng Ke, Fanqi Meng, Yuan Wu

et al.

Talanta, Journal Year: 2024, Volume and Issue: 280, P. 126710 - 126710

Published: Aug. 16, 2024

Language: Английский

Citations

5
Unraveling the Intricate Roles of Exosomes in Cardiovascular Diseases: A Comprehensive Review of Physiological Significance and Pathological Implications DOI Open Access

Shuai Zhang,

Yu Yang,

Xinchen Lv

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15677 - 15677

Published: Oct. 27, 2023

Exosomes, as potent intercellular communication tools, have garnered significant attention due to their unique cargo-carrying capabilities, which enable them influence diverse physiological and pathological functions. Extensive research has illuminated the biogenesis, secretion, functions of exosomes. These vesicles are secreted by cells in different states, exerting either protective or harmful biological Emerging evidence highlights role cardiovascular disease (CVD) mediating comprehensive interactions among cell types. This review delves into impacts exosomes on CVD under stress conditions, including coronary artery (CAD), myocardial infarction, heart failure, other cardiomyopathies. Focusing cellular signaling mechanisms, we explore how mediate multifaceted interactions, particularly contributing endothelial dysfunction, oxidative stress, apoptosis pathogenesis. Additionally, show great promise biomarkers, reflecting differential expressions NcRNAs (miRNAs, lncRNAs, circRNAs), therapeutic carriers for targeted treatment. However, specific regulatory mechanisms governing remain incomplete, necessitating further exploration characteristics roles various CVD-related contexts. aims provide novel insights implications offer innovative perspectives diagnosis treatment CVD.

Language: Английский

Citations

12
Mesenchymal stem cell–derived extracellular vesicles in periodontal bone repair DOI

Mengbing Chen,

Bo Huang, Xiaoxia Su

et al.

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

Citations

0
Menopause mysteries: the exosome-inflammation connection DOI Creative Commons

Aarushi Sultania,

Subhashini Brahadeeswaran,

Aparna Eledath Kolasseri

et al.

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 23, 2025

Extracellular vesicles, or exosomes, are produced by every type of cell and contain metabolites, proteins, lipids, nucleic acids. Their role in health disease is to influence different aspects biology act as intermediaries between cells. Follicular fluid exosomes extracellular vesicles (FF-EVs) secreted ovarian granulosa cells critical mediators ovary growth maturation. The movement proteins these crucial the regulation cellular communication aging cells, a process termed inflammaging. Menopause, natural progression females, often accompanied numerous negative symptoms issues. It can also precursor more severe problems, including neurological, cardiovascular, metabolic diseases, well gynecological cancers. Researchers have discovered pathways that reveal diverse effects exosome-driven oocyte development follicular fluid. explores complex functions FF exosomal pathologies associated with menopause.

Language: Английский

Citations

0