Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 31, 2024
Abstract
In
the
post‐large
era,
various
COVID‐19
sequelae
are
getting
more
and
attention
to
health
problems.
Although
mortality
rate
of
infection
is
now
declining,
it
often
accompanied
by
new
clinical
with
different
symptoms
such
as
fatigue
after
infection,
loss
smell.
The
degree
age,
gender,
virus
seems
be
weakly
correlated
symptoms.
Human
genetic
variation
plays
a
significant
role
in
infection.
This
study
aims
analyze
genomic
differences
between
individuals
sequelae.
this
study,
exomes
97
patients
Omicron
8
unique
manifestations
sequenced,
conducted
systematic
analysis.
Based
on
non‐negative
matrix
factorization
algorithms,
trinucleotide
mutation
spectrum
four
long‐term
genomes
summarized
found
that
have
DNA
patterns
indel
patterns.
By
constructing
Genomic
Fingerprinting
Framework,
driver
genes
each
symptomatic
population
deciphered
analyzed.
showed
population‐specific
mutational
fingerprint
main
cause
heterogeneity
provides
ideas
insights
into
causes
Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 24, 2023
Introduction
As
the
repercussions
from
COVID-19
pandemic
continue
to
unfold,
an
ever-expanding
body
of
evidence
suggests
that
infection
also
elicits
pathophysiological
manifestations
within
central
nervous
system
(CNS),
known
as
neurological
symptoms
post-acute
sequelae
COVID
(NeuroPASC).
Although
impairments
and
associated
with
NeuroPASC
have
been
well
described
in
literature,
its
etiology
remains
be
fully
characterized.
Objectives
This
mini-review
explores
current
literature
elucidates
various
mechanisms
underlining
NeuroPASC,
players,
regulators,
leading
persistent
neuroinflammation
affected
individuals.
Specifically,
we
provide
some
insights
into
roles
played
by
microglial
astroglial
cell
reactivity
how
these
subsets
potentially
contribute
impairment
response
direct
or
indirect
CNS
injury.
Discussion
A
better
understanding
biomarkers
this
maladaptive
neuroimmune
will
thus
diagnostic
strategies
for
reveal
new
potential
therapeutic
intervention.
Altogether,
elucidation
pathogenesis
improve
patient
outcomes
mitigate
socioeconomic
burden
syndrome.
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: Aug. 22, 2023
Background
A
substantial
proportion
of
individuals
with
COVID-19
experienced
cognitive
impairment
after
resolution
SARS-CoV-2
infection.
We
aimed
to
evaluate
whether
genetic
liability
infection
per
se
,
or
more
severe
COVID-19,
is
causally
linked
deficit.
Methods
firstly
performed
univariable
Mendelian
randomization
(MR)
analysis
examine
infection,
hospitalized
and
associated
performance.
To
dissect
the
causal
pathway,
multivariable
MR
(MVMR)
was
conducted
by
adjusting
for
five
inflammatory
markers
[C-reactive
protein,
interleukin
(IL)-1β,
IL-6,
IL-8,
tumour
necrosis
factor
α,
as
proxies
systemic
inflammation].
Results
In
analysis,
host
lower
performance
[inverse
variance
weighted
(IVW)
estimate:
−0.023;
95%
Confidence
Interval
(CI):
−0.038
−0.009].
Such
association
attenuated
in
MVMR
when
we
adjusted
correlated
one
(IVW
−0.022;
CI:
−0.049
0.004).
There
insufficient
evidence
Conclusion
The
effect
on
reduced
may
be
mediated
inflammation.
Future
studies
examining
anti-inflammatory
agents
could
alleviate
SARS-CoV-2-infected
are
warranted.
European Psychiatry,
Journal Year:
2024,
Volume and Issue:
67(1)
Published: Jan. 1, 2024
Abstract
Background
Cognitive
impairment
(CI)
is
one
of
the
most
prevalent
and
burdensome
consequences
COVID-19
infection,
which
can
persist
up
to
months
or
even
years
after
remission
infection.
Current
guidelines
on
post-COVID
CI
are
based
available
knowledge
treatments
used
for
improving
in
other
conditions.
The
current
review
aims
provide
an
updated
overview
existing
evidence
efficacy
CI.
Methods
A
systematic
literature
search
was
conducted
studies
published
December
2023
using
three
databases
(PubMed–Scopus–ProQuest).
Controlled
noncontrolled
trials,
cohort
studies,
case
series,
reports
testing
interventions
subjects
with
following
infection
were
included.
Results
After
screening
7790
articles,
29
Multidisciplinary
approaches,
particularly
those
combining
cognitive
remediation
interventions,
physical
exercise,
dietary
sleep
support,
may
improve
address
different
needs
individuals
post-COVID-19
condition.
a
safe,
cost-effective
option
be
tailored
deficits
specific
domains.
Noninvasive
brain
stimulation
techniques
hyperbaric
oxygen
therapy
showed
mixed
preliminary
results.
Evidence
including
pharmacological
ones,
remains
sparse.
Challenges
interpreting
include
heterogeneity
study
designs,
assessment
tools,
recruitment
criteria;
lack
long-term
follow-up;
under-characterization
samples
relation
confounding
factors.
Conclusions
Further
research,
grounded
shared
definitions
condition
accurate
COVID-related
CI,
well-defined
longer
follow-ups,
crucial
this
significant
unmet
need.
Frontiers in Public Health,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 27, 2024
Introduction
The
COVID-19
pandemic
has
prompted
global
research
efforts
to
reduce
infection
impact,
highlighting
the
potential
of
cross-disciplinary
collaboration
enhance
quality
and
efficiency.
Methods
At
FMUSP-HC
academic
health
system,
we
implemented
innovative
flow
management
routines
for
collecting,
organizing
analyzing
demographic
data,
COVID-related
data
biological
materials
from
over
4,500
patients
with
confirmed
SARS-CoV-2
hospitalized
2020
2022.
This
strategy
was
mainly
planned
in
three
areas:
a
database
hospitalizations;
setting-up
multidisciplinary
taskforce
conduct
follow-up
assessments
after
discharge;
biobank.
Additionally,
curated
collection
created
within
institutional
digital
library
papers
map
output.
Results
Over
course
experience,
possible
benefits
challenges
this
type
support
approach
were
identified
discussed,
leading
set
recommended
strategies
institution.
Demographic
clinical
hospitalizations
compiled
including
adults
minority
children
adolescents
laboratory
COVID-19,
covering
2020–2022,
approximately
350
fields
per
patient.
To
date,
been
used
16
published
studies.
assessed
700
6
11
months
hospitalization
through
comprehensive,
in-person
evaluations;
database,
comprising
around
2000
subject,
15
publications.
Furthermore,
thousands
blood
samples
collected
during
acute
phase
remain
stored
future
investigations.
more
than
3,700
aliquots
have
ongoing
investigating
various
aspects
COVID-19.
Lastly,
mapping
overall
output
revealed
that
between
2022
our
system
produced
1,394
scientific
articles
on
Discussion
Research
is
crucial
component
an
effective
epidemic
response,
preparation
process
should
include
well-defined
plan
sharing
resources.
initiatives
described
present
paper
successful
aim
foster
large-scale
Although
single
model
may
not
be
appropriate
all
contexts,
open
make
systems
efficient
generate
best
evidence.
Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 300 - 315
Published: Oct. 10, 2024
Abstract
Dementia
risk
factors
are
important
to
recognize
with
the
growing
population
of
older
adults.
Due
immunosenescence
and
common
comorbidities,
adults
particularly
susceptible
infectious
diseases,
scientific
literature
demonstrates
a
strong
association
between
diseases
dementia
risk.
Many
such
infections
potentially
preventable
through
vaccinations,
studies
show
that
antiviral
agents
reduce
As
such,
public
health
measures
related
may
also
lower
incidence.
This
chapter
discusses
broad
range
central
nervous
system
other
infections,
among
individuals
mechanisms
action.
