Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 21, 2024
Arthritis
often
results
in
unmet
healthcare
needs
for
older
adults
with
cognitive
decline,
who
may
struggle
to
communicate
pain
or
recall
symptoms.
However,
the
risk
factors
arthritis
this
group
remain
underexplored.
We
addressed
gap
by
identifying
and
comparing
among
varying
statuses.
Data
from
334
participants
decline
808
normal
cognition
were
analysed
using
Korean
Longitudinal
Study
of
Aging,
tracking
diagnoses
over
12
years
Kaplan–Meier
curves
Cox
proportional
hazards
regression.
Results
showed
47.6%
developed
arthritis,
compared
30.1%
cognition.
Key
included
depressive
symptoms
(hazard
ratio
[HR]:
1.87),
living
alone
(HR:
1.66),
infrequent
social
interactions
1.42),
greater
dependency
daily
activities
1.41).
In
group,
additional
chronic
illnesses
1.41)
higher
body
mass
index
1.09)
significant
factors.
Understanding
these
distinct
is
crucial
preventing
managing
at
groups.
Moreover,
findings
can
assist
developing
comprehensive
public
health
strategies
integrating
mental
support
improve
outcomes
decline.
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 1, 2025
Abstract
INTRODUCTION
Knowledge
gaps
remain
about
the
prognosis
of
mild
cognitive
impairment
(MCI).
Conversion
rates
to
dementia
vary
widely,
and
reversion
normal
cognition
has
gained
attention.
This
review
updates
evidence
on
MCI
conversion
risk
probability
stability
reversion.
METHODS
We
searched
databases
for
studies
with
≥3
years
follow‐up,
established
criteria
dementia,
performed
a
meta‐analysis
using
random‐effects
model
assess
risk,
reversion,
probability.
Meta‐regressions
identified
sources
heterogeneity
guided
subgroup
analysis.
RESULTS
From
89
(mean
follow‐up:
5.2
years),
was
41.5%
(38.3%–44.7%)
in
clinical
27.0%
(22.0%–32.0%)
population‐based
studies,
Alzheimer's
as
most
common
outcome.
Stability
were
49.3%
(clinical)
49.8%
(population).
Reversion
8.7%
28.2%
DISCUSSION
Our
findings
highlight
higher
settings
30%
population
calling
sustainable
care
pathway
development.
Highlights
Prognosis
(MCI)
varies
by
setting;
is
lower
clinical‐based
studies.
In
both
settings,
≈50%.
A
reorganization
health
services
could
ensure
individuals
MCI.
Significant
impacts
data
interpretation;
follow‐up
length
crucial.
Long‐term
low‐
middle‐income
countries
are
urgently
needed.
Alzheimer s & Dementia,
Journal Year:
2023,
Volume and Issue:
20(3), P. 1550 - 1561
Published: Dec. 2, 2023
Abstract
INTRODUCTION
To
examine
the
burden
and
clusters
of
multimorbidity
in
association
with
mild
cognitive
impairment
(MCI),
dementia,
Alzheimer's
disease
(AD)‐related
plasma
biomarkers
among
older
adults.
METHODS
This
population‐based
study
included
5432
participants
(age
≥60
years);
these,
amyloid
beta
(Aβ),
total
tau,
neurofilament
light
chain
(NfL)
were
measured
a
subsample
(
n
=
1412).
We
used
hierarchical
clustering
to
generate
five
from
23
chronic
diseases.
diagnosed
dementia
MCI
following
international
criteria.
Data
analyzed
using
logistic
linear
regression
models.
RESULTS
The
number
diseases
was
associated
(multivariable‐adjusted
odds
ratio
1.22;
95%
confidence
interval
[CI]
1.11
1.33),
AD
(1.13;
1.01
1.26),
vascular
(VaD)
(1.44;
1.25
1.64),
non‐amnestic
(1.25;
1.13
1.37).
Metabolic
cluster
VaD
MCI,
whereas
degenerative
ocular
p
<
0.05).
increased
Aβ
NfL
DISCUSSION
Multimorbidity
are
differentially
subtypes
AD‐related
Highlights
multimorbidity.
presence
load
impairment.
biomarkers.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 6, 2024
The
global
prevalence
of
type
2
diabetes
mellitus
(T2DM)
and
Alzheimer’s
disease
(AD)
is
rapidly
increasing,
revealing
a
strong
association
between
these
two
diseases.
Currently,
there
are
no
curative
medication
available
for
the
comorbidity
T2DM
AD.
Ceramides
structural
components
cell
membrane
lipids
act
as
signal
molecules
regulating
homeostasis.
Their
synthesis
degradation
play
crucial
roles
in
maintaining
metabolic
balance
vivo
,
serving
important
mediators
development
neurodegenerative
disorders.
Abnormal
ceramide
metabolism
disrupts
intracellular
signaling,
induces
oxidative
stress,
activates
inflammatory
factors,
impacts
glucose
lipid
homeostasis
metabolism-related
tissues
like
liver,
skeletal
muscle,
adipose
tissue,
driving
occurrence
progression
T2DM.
connection
changes
levels
brain,
amyloid
β
accumulation,
tau
hyper-phosphorylation
evident.
Additionally,
regulates
survival
apoptosis
through
related
signaling
pathways,
actively
participating
Regulatory
enzymes,
their
metabolites,
pathways
impact
core
pathological
molecular
mechanisms
shared
by
AD,
such
insulin
resistance
response.
Consequently,
may
become
potential
therapeutic
target
intervention
paper
comprehensively
summarizes
discusses
role
its
metabolites
pathogenesis
well
latest
progress
treatment
with
Alzheimer s & Dementia,
Journal Year:
2024,
Volume and Issue:
20(9), P. 6133 - 6145
Published: July 9, 2024
Abstract
INTRODUCTION
Evidence
has
emerged
that
cardiometabolic
multimorbidity
(CMM)
is
associated
with
dementia,
but
the
underlying
mechanisms
are
poorly
understood.
METHODS
This
population‐based
study
included
5704
older
adults.
Of
these,
data
were
available
in
1439
persons
for
plasma
amyloid‐β
(Aβ),
total
tau,
and
neurofilament
light
chain
(NfL)
1809
serum
cytokines.
We
defined
CMM
following
two
common
definitions
used
previous
studies.
Data
analyzed
using
general
linear,
logistic,
mediation
models.
RESULTS
The
presence
of
was
significantly
an
increased
likelihood
Alzheimer's
disease
(AD),
vascular
dementia
(VaD)
(
p
<
0.05).
Aβ40,
Aβ42,
NfL,
whereas
visceral
obesity
analysis
suggested
NfL
mediated
association
AD.
DISCUSSION
AD,
VaD
neurodegenerative
pathway
involved
Highlights
likelihoods
AD‐related
biomarkers
inflammatory
Neurodegenerative
partly
Frontiers in Psychology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 3, 2025
Purpose
Despite
the
wealth
of
data
on
role
chronic
disease
comorbidity
in
shaping
cognitive
dysfunction
older
adults,
a
comprehensive
view
this
dynamic
interplay
remains
frontier.
This
study
will
reveal
intricate
interactions
between
number
diseases
and
function
elderly,
based
perspective
patients
with
multiple
diseases.
Methods
Our
was
from
2023
China
Psychological
Care
for
Elderly
Action
Survey,
SPSS
26.0
(IBM
Corp.,
Armonk,
NY,
United
States)
software
package
used
mediation
model
analysis.
The
approach
encompassed
descriptive
analysis
variables,
Spearman’s
correlation
analyses
to
explore
associations
moderated
Results
found
that
(
r
=
0.183,
p
<
0.001)
positively
correlated
function.
Anxiety
depression
partially
mediated
relationship
β
0.227,
0.235,
both
0.001).
Age
association
0.010,
Conclusion
provides
establishes
new
adults.
It
suggests
we
should
pay
attention
negative
impact
elderly
improve
their
psychological
coping
ability,
so
as
ensure
stable
development
healthy
aging.
Fluids and Barriers of the CNS,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: April 3, 2025
Abstract
Background
The
choroid
plexus
(ChP)
plays
an
important
role
in
producing
cerebrospinal
fluid
(CSF)
and
physical
dysfunction
has
been
associated
with
alterations
CSF
circulation.
However,
no
population-based
studies
have
thus
far
examined
the
association
of
ChP
function
older
people.
Methods
This
cross-sectional
study
included
1217
participants
(age
≥
60
years;
57.35%
women)
MRI
substudy
Multimodal
Interventions
to
delay
Dementia
disability
rural
China.
volume
was
automatically
segmented
using
three-dimensional
T1-weighted
sequences.
Physical
assessed
Short
Performance
Battery
(SPPB).
Data
were
analyzed
general
linear
regression
mediation
models.
Results
Controlling
for
demographic
characteristics,
cardiovascular
risk
factors,
stroke,
disproportionately
enlarged
subarachnoid-space
hydrocephalus
(DESH),
total
intracranial
volume,
per
1-ml
increase
β-coefficient
-0.24
(95%
confidence
interval:
-0.37
-0.11)
SPPB
summary
score,
being
stronger
females
(-0.40;
-0.60
-0.20)
than
males
(-0.17;
-0.33
-0.01)
(p
volume×sex
interaction
=
0.028).
associations
similar
across
three
domains
balance,
chair
stand,
walking
speed.
In
addition,
increased
ventricular
white
matter
hyperintensity
(WMH)
volume.
Mediation
analysis
suggested
that
lateral
periventricular
WMH
significantly
mediated
proportion
54.22%
14.48%,
respectively.
Conclusion
Larger
is
poorer
adults,
especially
women.
largely
by
volumes.
Graphical
