Umbrella review and Delphi study on modifiable factors for dementia risk reduction

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 20(3), P. 2223 - 2239

Published: Dec. 30, 2023

Abstract A 2013 systematic review and Delphi consensus study identified 12 modifiable risk protective factors for dementia, which were subsequently merged into the “LIfestyle BRAin health” (LIBRA) score. We systematically evaluated whether LIBRA requires revision based on new evidence. To identify suitable dementia reduction, we combined an umbrella of reviews meta‐analyses with a two‐round study. The 608 unique primary studies opinions 18 experts prioritized six factors: hearing impairment, social contact, sleep, life course inequalities, atrial fibrillation, psychological stress. Based expert ranking, sleep considered most candidates inclusion in updated scores. As such, current shows that scores need updates emerging Future will validate score different cohorts. Highlights An was experts. Various candidate targets reduction identified. Experts sleep. Re‐assessment is encouraged. work should evaluate predictive validity

Language: Английский

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A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults—study design and baseline characteristics of the FINGER-NL randomized controlled trial

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 13, 2024

Abstract Background Evidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without dementia is mixed. Embedded World-Wide FINGERS initiative, FINGER-NL aims investigate a 2-year intervention functioning Dutch at risk individuals. Methods Multi-center, randomized, controlled, trial with duration 24 months. 1210 adults between 60–79 years old presence ≥ 2 modifiable factors and 1 non-modifiable factor for were recruited January 2022 May 2023 via Brain Research Registry across five study sites Netherlands. Participants randomized either high-intensity or low-intensity group. The comprises combination 7 components (physical activity, training, cardiovascular management, nutritional counseling, sleep stress social activities) product (Souvenaid®) that could help maintain functioning. group receives personalized, supervised hybrid consisting meetings (on-site online) individual sessions guided by trained coach, access digital platform provides custom-made training materials selected apps. bi-monthly online lifestyle-related health advice platform. Primary outcome change composite score covering processing speed, executive function, memory. Results Within 17 months, participant recruitment has been successfully completed ( N = 1210; mean age: 67.7 (SD: 4.6); 64% female). Modifiable commonly present baseline physical inactivity (89%), low mental/cognitive activity (50%), engagement (39%), hypertension (39%) high alcohol consumption (39%). body mass index participants was 28.3 4.2) total serum cholesterol 5.4 mmol/L 1.2). Conclusions Baseline clinical measurements showed successful sufficient potential prevention. will provide further insight into efficacy adults. Trial registration ClinicalTrials.gov (ID: NCT05256199)/2022–01-11.

Language: Английский

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A Pilot Study of BRAIN BOOTCAMP, a Low-Intensity Intervention on Diet, Exercise, Cognitive Activity, and Social Interaction to Improve Older Adults’ Dementia Risk Scores

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Multimodal dementia identification using lifestyle and brain lesions, a machine learning approach

AIP Advances, Journal Year: 2024, Volume and Issue: 14(6)

Published: June 1, 2024

Dementia diagnosis often relies on expensive and invasive neuroimaging techniques that limit access to early screening. This study proposes an innovative approach for facilitating dementia screening by estimating diffusion tensor imaging (DTI) measures using accessible lifestyle brain factors. Conventional DTI analysis, though effective, is hindered high costs limited accessibility. To address this challenge, fuzzy subtractive clustering identified 14 influential variables from the Lifestyle Brain Health Atrophy Lesion Index frameworks, encompassing demographics, medical conditions, factors, structural markers. A multilayer perceptron (MLP) neural network was developed these selected predict fractional anisotropy (FA), a metric reflecting white matter integrity cognitive function. The MLP model achieved promising results, with mean squared error of 0.000 878 test set FA prediction, demonstrating its potential accurate estimation without costly techniques. values in dataset ranged 0 1, higher indicating greater integrity. Thus, suggests model’s predictions were highly compared observed values. multifactorial aligns current understanding dementia’s complex etiology influenced various biological, environmental, By integrating readily available data into predictive model, method enables widespread, cost-effective risk assessment. proposed tool could facilitate timely interventions, preventive strategies, efficient resource allocation public health programs, ultimately improving patient outcomes caregiver burden.

Language: Английский

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A Brief History of the Progress in Our Understanding of Genetics and Lifestyle, Especially Diet, in the Risk of Alzheimer’s Disease

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 100(s1), P. S165 - S178

Published: Aug. 6, 2024

The two major determining factors for Alzheimer's disease (AD) are genetics and lifestyle. Alleles of the apolipoprotein E (APOE) gene play important roles in development late-onset AD, with APOEɛ4 increasing risk, APOEɛ3 being neutral, APOEɛ2 reducing risk. Several modifiable lifestyle have been studied terms how they can modify risk AD. Among these dietary pattern, nutritional supplements such as omega-3 fatty acids, B vitamins, physical exercise, obesity, vitamin D. Western diet increases while patterns Mediterranean vegetarian/vegan diets reduce Foods associated reduced include coffee, fruits vegetables, whole grains legumes, fish, meat ultraprocessed foods increased especially when lead to obesity. In multi-country ecological studies, amount national has highest correlation history research regarding on AD is emphasized this review. be modified starting at least by mid-life. People greater genetic would benefit more choosing and/or delay incidence

Language: Английский

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Development and evaluation of a free e-learning program on dementia risk reduction for the general public: A pre-post study

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Background There is consistent evidence for the contribution of modifiable risk factors to dementia risk, offering opportunities primary prevention. Yet, most individuals are unaware these opportunities. Objective To investigate whether online education about reduction may be a low-level means increase knowledge and support self-management factors. Methods A pre-post study was conducted with Dutch community-dwelling who registered free e-learning course called “Keep your brain healthy”. The covers seven themes delivered week-by-week covering cognitive physical activity, diet, cardiovascular health, amongst others. Participants completed an survey before starting e-learning, immediately afterwards, three months later. covered user experience, on reduction, motivation for, engagement in, health behaviors. Results Of 477 participants (70.9% women, mean age = 63 years), 339 (71.1%) after 241 (50.5%) three-month follow-up survey. User experiences were positive weekly receiving average ratings between 7.9–8.1 out 10. Improvements over time seen in Mediterranean diet adherence, social contact satisfaction, activity. Cognitive activity levels alcohol consumption improved women. Moreover, improvements adherence remained present completion. Conclusions This program positively perceived, increased promoted brain-healthy lifestyles. can easily implemented as stand-alone tool or part larger initiatives.

Language: Английский

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Acceptability and fidelity of the multidomain ‘Brain Bootcamp’ dementia risk reduction program: a mixed-methods approach

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 14, 2025

Abstract Background Interventions targeting dementia prevention typically lack comprehensive exploration of feasibility, acceptability, and long-term translation factors prior to deployment. Our study aimed explore the fidelity participants’ experiences with Brain Bootcamp, a multi-domain behaviour change intervention reduced risk increased factor awareness for older adults. Methods Conducted in New South Wales, Australia, from January August 2021, our concurrent single-group mixed-methods feasibility involved post-intervention surveys qualitative interviews community-dwelling Descriptive statistics were used assess acceptability methods, outcome measures, program components. Thematic analysis semi-structured explored participant experiences, preferences, barriers, recommendations. Results Out 853 enrolled participants, only 355 completed (41.6%). Among these 79.1% agreed that improved their factors, 92.4% expressed intent continue maintaining brain healthy behaviours post- program. Participants set 2–4 modifiable lifestyle goals, which most often related physical activity (83.7%). A majority (91.5%) successfully achieved at least one health goal. Qualitative analyses ( n = 195) identified three overarching themes on role education modification (i.e., transformative enhancing knowledge about fostering behavioral modifications), psychological considerations (e.g., intrinsic versus extrinsic motivation engagement perception program) future directions sustainability concerns need tailored strategies specific demographics). Conclusions While Bootcamp had low completion rates, those who reported high acceptability. Future refinements, incorporating targeted enhanced support communication, will facilitate pragmatic initiatives. Clinical trial number ACTRN12621000165886.

Language: Английский

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Behaviour change techniques used in interventions targeting dementia risk factors amongst older adults in rural and remote areas: A systematic review and meta-analysis

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100093 - 100093

Published: Feb. 1, 2025

Language: Английский

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Midlife dementia risk scores in a multi-ethnic population in the Netherlands: the HELIUS study

Journal of Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Migrant populations in the Netherlands may face greater dementia risk factor burden than Dutch natives. To study whether midlife scores differ by ethnicity. We calculated three validated participants aged 40-70 years of (n = 2978), South-Asian Surinamese 2084), African 3135), Ghanaian 1699), Turkish 2000), and Moroccan 2025) background, from HELIUS (Amsterdam, Netherlands): Cardiovascular Risk Factors, Aging Incidence Dementia (CAIDE), LIfestyle for BRAin Health (LIBRA), Australian National University-Alzheimer's Disease Index (ANU-ADRI). cross-sectionally compared between ethnicities using linear regression. Ethnic minority groups had higher those with a background (CAIDE: +0.66-1.35; LIBRA: +0.66-1.43; ANU-ADRI: +2.75-7.25). CAIDE estimated an absolute 20-year incident 2.6% Dutch, 3.4% Surinamese, 3.6% Turkish, 3.7% Moroccan, 4.5% populations. Differences were when removing age (CAIDE +0.89-2.22; ANU-ADRI +3.03-8.20), implying that this score is independent age. Validation these migrant warranted. If replicated, ethnicity should be considered estimating developing preventive strategies high-risk

Language: Английский

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Associations of social isolation with memory and cognitive function in middle-aged and older Chinese adults

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 8, 2025

Abstract Background Although social isolation has been identified as a risk factor for cognitive impairment, its potential impact relative to other documented factors not comprehensively quantified, leading underestimation in public health strategies. We aimed address this gap by quantifying the contribution of decline context factors. Methods Social was evaluated using modified Network Index (SNI) and function through Delayed Word Recall Test (DWRT) Mini-Mental State Examination (MMSE). Linear logistic regression models were employed analyze associations between outcomes, adjusting demographic health-related Additionally, XGBoost algorithm with SHapley Additive exPlanations (SHAP) used quantify importance predictors. Results A total 25,981 participants recruited from 2003 2008. The mean age 62.0 years, 28.4% being men. Higher significantly associated lower DWRT (β=-0.15; 95% CI: -0.21 -0.09) MMSE scores (β=-0.34; -0.48 -0.19), higher odds memory impairment (OR = 1.27; 1.15 1.40) poor 1.56; 1.23 1.99). analysis ranked fifth most important predictor (SHAP value 0.175) eighth 0.0133). Subgroup analyses indicated stronger among older adults, individuals education or manual occupation. Conclusion Our findings showed that is an outcomes. This underscores urgent need targeted interventions addressing isolation, alongside key factors, preserve health.

Language: Английский

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