Brain structural associations of syntactic complexity and diversity across schizophrenia spectrum and major depressive disorders, and healthy controls DOI Creative Commons

Katharina Schneider,

Nina Alexander, Andreas Jansen

et al.

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 1, 2024

Deviations in syntax production have been well documented schizophrenia spectrum disorders (SSD). Recently, we shown evidence for transdiagnostic subtypes of syntactic complexity and diversity. However, there is a lack studies exploring brain structural correlates across diagnoses. We assessed diversity oral language using four Thematic Apperception Test pictures sample N = 87 subjects (n 24 major depressive disorder (MDD), n 30 SSD patients both diagnosed according to DSM-IV-TR, 33 healthy controls (HC)). General linear models were used investigate the association with gray matter volume (GMV), fractional anisotropy (FA), axial (AD), radial (RD), mean diffusivity (MD). Age, sex, total intracranial volume, group, interaction group covariates no interest. Syntactic was positively correlated GMV right medial pre- postcentral gyri FA left superior-longitudinal fasciculus (temporal part). Conversely, AD cingulum bundle forceps minor negatively The inferior-longitudinal complexity. Negative associations observed between bundle, fasciculus, uncinate fasciculus. Our study showed diagnoses HC. This contributes comprehensive understanding interplay linguistic neural substrates psychiatric

Language: Английский

Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study DOI Creative Commons

Y Chen,

Liling Chen, Li‐Yu Hu

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111213 - 111213

Published: Jan. 15, 2025

Language: Английский

Citations

1
Altered cerebellar and caudate gray‐matter volumes and structural covariance networks preceding dual cognitive and mobility impairments in older people DOI Creative Commons
Pei‐Lin Lee, Kun‐Hsien Chou, Wei‐Ju Lee

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(4), P. 2420 - 2433

Published: Feb. 1, 2024

Abstract INTRODUCTION The neuroanatomical changes driving both cognitive and mobility impairments, an emerging preclinical dementia syndrome, are not fully understood. We examined gray‐matter volumes (GMVs) structural covariance networks (SCNs) abnormalities in community‐based older people preceding the conversion to physio‐cognitive decline syndrome (PCDS). METHODS Voxel‐wise brain GMV established SCNs were compared between PCDS non‐PCDS converters. RESULTS study included 343 individuals (60.2 ± 6.9 years, 49.6% men) with intact functions. Over average 5.6‐year follow‐up, 116 transitioned PCDS. Identified regions abnormal GMVs converters over cerebellum caudate, which served as seeds for establishment. Significant differences cerebellum‐based (to right frontal pole left middle gyrus) caudate‐based caudate putamen, planum temporale, precentral gyrus, postcentral parietal operculum) nonconverters observed. DISCUSSION This reveals early neuroanatomic changes, emphasizing cerebellum's role, dual impairments. Highlights Neuroanatomic precursors of impairments identified. Cerebellar reductions increased precede onset Altered cerebellum‐ drive transformation. research establishes a foundation understanding specific syndrome.

Language: Английский

Citations

7
Association between oral health and physio-cognitive decline syndrome of older adults in China and its sex differences: a cross-sectional study DOI Creative Commons

Yaxin Li,

Min Guo, Fei Yang

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 28, 2025

Physio-Cognitive Decline Syndrome (PCDs) is characterized by the coexistence of MIND (mobility impairment, no disability) and CIND (cognitive dementia), which predicts dementia risk. Deteriorating oral health can contribute to malnutrition, cognitive decline, physical frailty, all may exacerbate PCDs symptoms. This study investigates association between PCDs, exploring sex differences in this relationship. A cross-sectional analysis baseline data from Nanjing Brain Health Cohort included 252 participants aged 60 older, assessing mobility (6-meter walk test, grip strength), function (MoCA), (natural teeth count, denture use, tongue lip motor function, masticatory swallowing ability, Oral Frailty Index). Logistic regression models were used examine associations PCDs. Among participants, 15.5% classified as having The odds lower with a higher number (OR = 0.939, 95% CI: 0.890–0.991, p 0.021), while impaired increased 3.811, 1.059–13.717, 0.041). In females, greater use. For males, frailty 5.202, 1.429–18.940, 0.012). Findings underscore significant among older adults, sex-specific effects. women, maintaining natural proper use are associated CIND, for men, linked Healthcare providers should consider incorporate strategies.

Language: Английский

Citations

0
The grip on healthspan: Handgrip strength as a vital sign of aging DOI
Liang‐Kung Chen

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 122, P. 105436 - 105436

Published: April 4, 2024

Language: Английский

Citations

3
Integrating precision health with multidomain interventions to advance strategies for healthy aging DOI Creative Commons
Liang‐Kung Chen

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(10), P. 100354 - 100354

Published: Sept. 5, 2024

Language: Английский

Citations

2
Proteo‐metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle–brain crosstalk DOI Creative Commons
Yi‐Long Huang, Wei‐Ju Chang, Chen‐Hua Huang

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

We employed an untargeted proteo-metabolomic approach to profile circulating biomarkers in plasma samples from the I-Lan Longitudinal Aging Study, aiming identify and pathways associated with physio-cognitive decline syndrome (PCDS). In 115 propensity score-matched PCDS case-control pairs, pathway analyses implicated dysregulation of fatty acid metabolism inflammation pathogenesis. Sex-specific associations were observed, disruptions central carbon (elevated PKM, MDH1, GAPDH; decreased MINPP1) tyrosine (decreased MIF, DBH; increased thyroxine) characterizing men. contrast, perturbations glutathione phenylalanine metabolism, including ANPEP, GSTP1, pyroglutamic acid, identified women. Results suggest that dysregulated energy redox homeostasis likely contribute development. Notably, MIF emerged as potential biomarkers, elucidating muscle-brain crosstalk framework. Our findings provide insights into molecular mechanisms underlying crosstalk, marking progress toward journey healthy aging.

Language: Английский

Citations

2
Brain structural associations of syntactic complexity and diversity across schizophrenia spectrum and major depressive disorders, and healthy controls DOI Creative Commons

Katharina Schneider,

Nina Alexander, Andreas Jansen

et al.

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 1, 2024

Deviations in syntax production have been well documented schizophrenia spectrum disorders (SSD). Recently, we shown evidence for transdiagnostic subtypes of syntactic complexity and diversity. However, there is a lack studies exploring brain structural correlates across diagnoses. We assessed diversity oral language using four Thematic Apperception Test pictures sample N = 87 subjects (n 24 major depressive disorder (MDD), n 30 SSD patients both diagnosed according to DSM-IV-TR, 33 healthy controls (HC)). General linear models were used investigate the association with gray matter volume (GMV), fractional anisotropy (FA), axial (AD), radial (RD), mean diffusivity (MD). Age, sex, total intracranial volume, group, interaction group covariates no interest. Syntactic was positively correlated GMV right medial pre- postcentral gyri FA left superior-longitudinal fasciculus (temporal part). Conversely, AD cingulum bundle forceps minor negatively The inferior-longitudinal complexity. Negative associations observed between bundle, fasciculus, uncinate fasciculus. Our study showed diagnoses HC. This contributes comprehensive understanding interplay linguistic neural substrates psychiatric

Language: Английский

Citations

1