Decreased water exchange rate across the blood–brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION Water exchange rate (Kw) across the blood–brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations Kw Alzheimer's disease (AD) continuum remain uncertain. METHODS The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A–), 30 (CN_A+), and 31 impaired (CI_A+) with positive biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, assays of plasma RESULTS Significantly lower was observed multiple brain regions throughout continuum. This alteration correlated neuropsychological performance. Elevated levels phosphorylated tau 217 intensified inverse relationship between integration Kw, volume, demonstrated potential distinguishing stages within DISCUSSION Consistently evident may act as a diagnostic tool for early screening. Highlights Observations revealed decline water continuum, notably hippocampus, parahippocampal gyrus, deep nuclei during preclinical stage AD. Strong correlations were established various biomarkers, well performance Interaction (p‐tau)217 hippocampus linked executive function, indicating combined detrimental impact on cognitive abilities stemming from both blood—brain p‐tau 217. use biomarkers—neurofilament light chain glial fibrillary acidic protein—demonstrated

Language: Английский

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Correlations between plasma markers and brain Aβ deposition across the AD continuum: Evidence from SILCODE

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 6170 - 6182

Published: July 10, 2024

Abstract BACKGROUND Previous studies have found that Alzheimer's disease (AD)‐related plasma markers are associated with amyloid beta (Aβ) deposition, but the change of this association in different Aβ pathological stages remains unclear. METHODS Data were obtained from SILCODE. According to standardized uptake value ratio (SUVR) and stage classification, correlation analysis was performed among biomarkers, voxel/SUVR values regions interest (ROI) clinical scale information, respectively. Mediation used study possible pathways. RESULTS The proportion cognitively normal (CN) subjective cognitive decline (SCD) highest A0 1, while A2 4, mild impairment (MCI) AD increased. Plasma phosphorylated tau (p‐tau)181 glial fibrillary acidic protein (GFAP) levels significantly lower compared later phases. Two pathways demonstrated fully mediated effects: positron emission tomography (PET) SUVR–plasma p‐tau181–Mini‐Mental State Examination (MMSE) PET GFAP–MMSE. DISCUSSION This role biomarkers early AD, especially SCD, both diagnosis dimensions. Highlights ptau181 GFAP level serve as indicators pathologic staging classification. A ceiling effect observed mid‐to‐late course. confirms promoting deposition at an stage, particularly females decline(SCD). overlapping brain p‐tau181, GFAP, neurofilament light for distributed across various regions, including posterior cingulate gyrus, rectus inferior temporal gyrus.

Language: Английский

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Insomnia and risk of all-cause dementia: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0318814 - e0318814

Published: April 9, 2025

Background The evidence on the relationship between insomnia and risk of dementia, Alzheimer’s disease (AD), Vascular dementia (VD) is not consistent. We conducted this meta-analysis to examine for developing AD, or VD in patients with all subtypes insomnia. Methods A comprehensive search PubMed, Embase, Cochrane Library was using following strings: ‘Insomnia OR Sleep initiation Maintenance disorders Early morning awakening’ AND ‘Dementia Disease Dementia’ ‘Risk’. Data extraction done independently by two researchers. Pooled odds ratio (OR) accompanied 95% confidence interval (CI) were calculated either a random-effects model fixed-effects model. Sensitivity analyses performed assess robustness findings. potential publication bias evaluated through Egger’s test Begg’s test. Results This included 16 studies combined sample size over 9 million individuals. revealed significant association (OR = 1.36; CI: 1.01-1.84), increased risks AD 1.52; 1.19-1.93) 2.10; CI 2.06-2.14). Subgroup showed no associations initial 1.01; 0.71-1.31), sleep-maintenance 0.88; 0.66-1.17), early awakening 0.94; 0.83-1.07) risk. Insomnia from Europe 1.24; 1.14-1.35), Asia 2.19; 2.06-2.32), Americas 1.05; 1.04-1.07) had varying dementia. Subgroups less than five years follow-up 2.16; 1.81-2.60) exhibited higher patients, while those more 1.17; 1.03-1.33) lower Conclusion Our reveals that linked VD. These findings suggest may significantly contribute all-cause highlighting importance intervention management Despite our efforts minimize explore sources heterogeneity, it still remained, therefore results should be interpreted caution.

Language: Английский

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A novel viscosity sensitive hemicyanine fluorescent dye for real-time imaging of amyloid-β aggregation

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 281, P. 117001 - 117001

Published: Oct. 30, 2024

Language: Английский

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