CIRCVMA21-RELATED PATHWAY ALLEVIATES LIPOPOLYSACCHARIDE-INDUCED HK-2 CELL INJURY DOI

Fuzhu Li,

Hongyun Fu,

Linna Zeng

et al.

Shock, Journal Year: 2024, Volume and Issue: 62(1), P. 119 - 126

Published: March 25, 2024

ABSTRACT Background : It is reported that circVMA21 has an inhibition effect on sepsis-induced acute kidney injury (AKI). Therefore, the underlying molecular mechanisms of in AKI are worthy further investigation. Material and Methods Lipopolysaccharide (LPS) was used to induce HK2 cell injury. CircVMA21, miR-337-3p ZEB2 expression tested by qRT-PCR. Cell growth detected CCK8 assay, EdU flow cytometry. Protein levels were examined western blot. The inflammatory factors oxidative stress markers measured evaluate response stress. RNA relationship as verified dual-luciferase reporter RIP pull-down assay. Results CircVMA21 had decreased patients. Overexpressed alleviated LPS-induced inflammation, apoptosis, Moreover, sponged miR-337-3p, targeted ZEB2. inhibitory reversed overexpression, overexpression abolished promotion Conclusions could inhibit via miR-337-3p/ZEB2 axis.

Language: Английский

Study the Expression of Two Circular RNAs, hsa_circ_0003227 and hsa_circ_0001666, in the Primary Breast Cancer Cell Line BT-20 and the Metastatic Breast Cancer Cell Line MCF-7 DOI

Safura Absalan,

Hamidreza Vaziri, Mahvash Hadavi

et al.

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

Citations

1
Ferroptosis and circular RNAs: new horizons in cancer therapy. DOI
Asif Ahmad Bhat,

Neelima Kukreti,

Muhammad Afzal

et al.

PubMed, Journal Year: 2024, Volume and Issue: 23, P. 570 - 599

Published: Jan. 1, 2024

Cancer poses intricate challenges to treatment due its complexity and diversity. Ferroptosis circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators pivotal influencers ferroptosis in cell lines. The results underscore significance modulating pathways that impact crucial aspects development, including survival, proliferation, metastasis. A detailed analysis delineates these pathways, shedding light on mechanisms through which influence ferroptosis. Building upon recent experimental findings, study evaluates potential targeting induce By identifying specific associated with etiology cancer, this paves way for development targeted therapeutics exploit vulnerabilities cells. This review consolidates existing understanding circRNAs, emphasizing role therapy providing impetus ongoing research dynamic field. See also graphical abstract(Fig. 1).

Language: Английский

Citations

7
Ferroptosis contributes to the progression of female-specific neoplasms, from breast cancer to gynecological malignancies in a manner regulated by non-coding RNAs: Mechanistic implications DOI Creative Commons
Kiavash Hushmandi, Daniel J. Klionsky, Amir Reza Aref

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1159 - 1177

Published: May 20, 2024

Ferroptosis, a recently identified type of non-apoptotic cell death, triggers the elimination cells in presence lipid peroxidation and an iron-dependent manner. Indeed, ferroptosis-stimulating factors have ability suppressing antioxidant capacity, leading to accumulation reactive oxygen species (ROS) subsequent oxidative death cells. Ferroptosis is involved pathophysiological basis different maladies, such as multiple cancers, among which female-oriented malignancies attracted much attention recent years. In this context, it has also been unveiled that non-coding RNA transcripts, including microRNAs, long RNAs, circular RNAs regulatory interconnections with ferroptotic flux, controls pathogenic development diseases. Furthermore, potential employing these transcripts therapeutic targets during onset female-specific neoplasms modulate ferroptosis become research hotspot; however, molecular mechanisms functional alterations still require further investigation. The current review comprehensively highlights its association focus on how crosstalk affects pathogenesis malignancies, from breast cancer ovarian, cervical, endometrial neoplasms, suggesting novel decelerate even block expansion tumors.

Language: Английский

Citations

5
CircRNA and ferroptosis in human disease: Insights for new treatments DOI Creative Commons

Ruoyu Liu,

Yun Zhou, Yongtong Cao

et al.

Animal Models and Experimental Medicine, Journal Year: 2023, Volume and Issue: 6(6), P. 508 - 517

Published: Dec. 1, 2023

Abstract Circular RNA (circRNA), classified as a type of non‐coding RNA, has gained significant attention in the field biology due to its distinctive ring structure and functional properties. Recent research provided evidence that specific circRNAs have ability modulate disease progression through diverse mechanisms, one which is by regulating cellular ferroptosis. Ferroptosis form regulated cell death driven iron dependency lipid peroxidation, extensive investigations revealed relationship between ferroptosis development. In addition both exert critical roles progression, also been shown actively mediate process The therefore influences offers novel targets for treatment. By directly or indirectly modulating expression regulate ferroptosis‐related proteins, it may be possible impact promoting inhibiting Current indicates such approaches hold value wide variety common diseases across physiological systems. This review comprehensively summarizes findings recent studies investigating regulation various diseases.

Language: Английский

Citations

13
Renal Tubular Epithelial Cell–Derived hsa_circ_0008925 From Urine Is Related to Chronic Renal Fibrosis DOI Creative Commons
Yuanhui Shi, Yuye Chen, Xiao Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(1)

Published: Jan. 1, 2025

ABSTRACT Renal fibrosis (RF) is a crucial pathological factor in the progression of chronic kidney disease (CKD) to end‐stage renal failure, and accurate noninvasive assays monitor are needed. Circular RNAs (circRNAs) noncoding that can be used as diagnostic biomarkers therapeutic targets for human diseases. In this study, we analysed expression hsa_circ_0008925 urinary tubular cells investigated its role fibrosis. Urinary samples were collected from CKD patients with varying degrees fibrosis; epithelial isolated using magnetic bead sorting. moderate–severe fibrosis, was elevated compared no mild Spearman correlation analysis indicated positively correlated serum creatinine (Scr, rs = 0.424, p 0.031). The TGF‐β1‐treated HK‐2 vitro. Silencing siRNA inhibited TGF‐β1‐induced HK2 cells. RNA pull‐down mass spectrometric analyses serine/arginine‐rich splicing 6 (SRSF6) downstream hsa_circ_0008925. mmu_circ_0002215 inhibiting SRSF6 alleviated UUO model vivo. Inhibiting hsa_circ_0008925/SRSF6 vitro These findings suggest targeting pathway could hold promise potential strategy treating

Language: Английский

Citations

0
Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer DOI Creative Commons
Xiang Pan, Kaiwen Chen, Wei Gao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Molecular epidemiological study of exosomes circZNF609, circPUM1, IGF2 with ischemic stroke DOI Creative Commons

Suhai Fei,

Miao Xu, Zhihong Liu

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 25, 2025

Ischemic stroke (IS) is a common cardiovascular disease (CVD). Insulin-like growth factor 2 (IGF2), circZNF609, and circPUM1 are involved in metabolic regulation, vascular health, neuroprotection, inflammation modulation relevant to IS mechanisms. This study investigated the effects of plasma exosomal expression circPUM1, IGF2 on IS. The mRNA exosomes was detected 145 patients with 290 controls using real-time qPCR cross-sectional study. Q1–Q4 represents quartile groups based target gene levels. There no significant difference levels circZNF609 between control (P > 0.05). However, nonlinear relationship group < Exosomal significantly lower than that = 0.043). multifactorial adjusted results showed case–control IS, associated reduced risk Q2 (adjusted OR: 0.565; P 0.035) compared Q1, low-expression group. In exosomes, Q4 Q1 0.654; 0.004) (low expression). Plasma high low 0.543; 0.042). suggests peripheral blood could pose potential for serve as biomarkers clinical treatment.

Language: Английский

Citations

0
Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential DOI
Thanyaporn Direksunthorn, Abdulrahman T. Ahmed,

Nakaraj Pluetrattanabha

et al.

Journal of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
Epigenetic and Post-Translational Modifications in Ferroptosis Regulation and Hepatocellular Carcinoma: New Frontiers in Therapeutic Targeting DOI

Soheil Bolandi,

Samaneh Dodge,

Zahra Zahed

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155991 - 155991

Published: April 1, 2025

Language: Английский

Citations

0
Inhibition of hsa_circ_0003314 contributes to trophoblast cell migration and invasion and inhibits pyroptosis in preeclampsia DOI
Yun Zhou, Yuqing Chen, Lihua Li

et al.

Histochemistry and Cell Biology, Journal Year: 2025, Volume and Issue: 163(1)

Published: May 16, 2025

Language: Английский

Citations

0