Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer DOI Creative Commons
Zhi Lin,

Chonglei Zhong,

Ming Shi

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: June 5, 2025

Abstract Ferroptosis, an iron-dependent form of programmed cell death, holds promise for cancer treatment. Circular RNAs (circRNAs), widely expressed across tumor types, modulate multiple cellular biological processes, including ferroptosis. However, the regulatory dynamics circRNAs in gastric (GC)-associated ferroptosis remain poorly understood. Here, circTFRC (circBase ID: hsa_circ_0068606), a novel circRNA, was identified as significantly upregulated GC tissues and lines, with its plasma levels strongly associated size metastatic status. Targeted suppression enhanced ferroptotic resulting reduced proliferation motility cells vitro. At molecular level, bound directly to SCD1 mRNAs, stabilizing enhancing their translation via recruiting RNA-binding protein ELAVL1. Elevated expression mitigated promoted oncogenic lipid metabolic reprogramming, thereby driving progression. In vivo studies further confirmed that silencing inhibited growth These results delineate circTFRC-mediated axis impairs vulnerability supports malignancy advancement. CircTFRC emerges biomarker diagnostic potential candidate therapeutic intervention targeting GC.

Language: Английский

Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration DOI
Riya Thapa, Asif Ahmad Bhat, Moyad Shahwan

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149202 - 149202

Published: Aug. 30, 2024

Language: Английский

Citations

10
Non-Coding RNAs as Key Regulators of Gasdermin-D Mediated Pyroptosis in Cancer Therapy DOI
Gaurav Gupta, Muhammad Afzal, Ehssan Moglad

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155490 - 155490

Published: July 26, 2024

Language: Английский

Citations

4
The paradox of autophagy in cancer: NEAT1's role in tumorigenesis and therapeutic resistance DOI
Salem Salman Almujri, Waleed Hassan Almalki

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155523 - 155523

Published: Aug. 13, 2024

Language: Английский

Citations

4
MicroRNA-21 (miR-21) in Breast Cancer: From Apoptosis Dysregulation to Therapeutic Opportunities DOI
Rahamat Unissa Syed,

Humera Banu,

Alia Alshammrani

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155572 - 155572

Published: Aug. 30, 2024

Language: Английский

Citations

4
The Impact of NF-κB on Inflammatory and Angiogenic Processes in Age-Related Macular Degeneration DOI
Waleed Hassan Almalki, Salem Salman Almujri

Experimental Eye Research, Journal Year: 2024, Volume and Issue: 248, P. 110111 - 110111

Published: Sept. 24, 2024

Language: Английский

Citations

4
CRBN‐PROTACs in Cancer Therapy: From Mechanistic Insights to Clinical Applications DOI Open Access
Riya Thapa, Asif Ahmad Bhat, Gaurav Gupta

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 104(5)

Published: Nov. 1, 2024

Cereblon (CRBN), a member of the E3 ubiquitin ligase complex, has gained significant attention as therapeutic target in cancer. CRBN regulates degradation various proteins cancer progression, including transcription factors and signaling molecules. PROTACs (proteolysis-targeting chimeras) are novel approach that uses cell's system to remove disease-causing selectively. CRBN-dependent work by tagging harmful for destruction through ubiquitin-proteasome system. This strategy offers several advantages over traditional protein inhibition methods, potential overcome drug resistance. Recent progress developing CRBN-based shown promising preclinical results both hematologic malignancies solid tumors. Additionally, have enhanced our understanding CRBN's role cancer, potentially serving biomarkers patient stratification predicting responses. In this review, we delineate mechanisms action (CRBN-PROTACs), summarize recent advances clinical applications, provide perspective on future development.

Language: Английский

Citations

4
Tau proteins and senescent Cells: Targeting aging pathways in Alzheimer’s disease DOI
Mahaveer Singh,

Haider Ali,

S. Renuka Jyothi

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1844, P. 149165 - 149165

Published: Aug. 22, 2024

Language: Английский

Citations

3
Ionizing and nonionizing radiation linked to lung cancer DOI
Asif Ahmad Bhat, Muhammad Afzal, Riya Thapa

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 237 - 255

Published: Jan. 1, 2025

Citations

0
Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer DOI Creative Commons
Zhi Lin,

Chonglei Zhong,

Ming Shi

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: June 5, 2025

Abstract Ferroptosis, an iron-dependent form of programmed cell death, holds promise for cancer treatment. Circular RNAs (circRNAs), widely expressed across tumor types, modulate multiple cellular biological processes, including ferroptosis. However, the regulatory dynamics circRNAs in gastric (GC)-associated ferroptosis remain poorly understood. Here, circTFRC (circBase ID: hsa_circ_0068606), a novel circRNA, was identified as significantly upregulated GC tissues and lines, with its plasma levels strongly associated size metastatic status. Targeted suppression enhanced ferroptotic resulting reduced proliferation motility cells vitro. At molecular level, bound directly to SCD1 mRNAs, stabilizing enhancing their translation via recruiting RNA-binding protein ELAVL1. Elevated expression mitigated promoted oncogenic lipid metabolic reprogramming, thereby driving progression. In vivo studies further confirmed that silencing inhibited growth These results delineate circTFRC-mediated axis impairs vulnerability supports malignancy advancement. CircTFRC emerges biomarker diagnostic potential candidate therapeutic intervention targeting GC.

Language: Английский

Citations

0