Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

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The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 20, 2024

Abstract Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel (CSVD) the most common pathogenesis We hypothesize that AD and CSVD could be associated glymphatic dysfunction, contributing to cognitive impairment. Method Participants completed amyloid PET, diffusion tensor imaging (DTI), T2 fluid-attenuated inversion-recovery (FLAIR) sequences were included from Disease Neuroimaging Initiative (ADNI). White matter hyperintensities (WMH), marker, was evaluated T2FLAIR images represented burden of CSVD. Amyloid PET used assess Aβ aggregation in brain. image analysis along perivascular space (DTI-ALPS) index, enlarged spaces (PVS), choroid plexus volume reflect function. The relationships between WMH burden/Aβ these markers as well correlations function investigated. Furthermore, we conducted mediation analyses explore potential mediating effects relationship cognition. Results One hundred thirty-three participants continuum included, consisting 40 CN − , 48 + 26 MCI 19 participants. Our findings revealed there negative associations whole-brain ( r = 0.249, p 0.022) 0.458, < 0.001) DTI-ALPS. Additionally, 0.223, 0.041) 0.294, 0.006) both positively volume. However, did not observe significant PVS enlargement severity. DTI-ALPS memory 0.470, FDR- 0.001), executive 0.358, visual-spatial 0.040), language 0.419, 0.001). Conversely, showed 0.315, 0.007), 0.321, 0.233, 0.031), 0.261, 0.021). There no severity performance. In analysis, found acted mediator accumulation performances. Conclusion study provided evidence pathology (Aβ) which further related These results may provide theoretical basis new targets treating AD.

Language: Английский

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The Association of the Glymphatic Function with Parkinson's Disease Symptoms: Neuroimaging Evidence from Longitudinal and Cross‐Sectional Studies

Annals of Neurology, Journal Year: 2023, Volume and Issue: 94(4), P. 672 - 683

Published: June 28, 2023

Emerging pathological evidence suggests that there is an association between glymphatic dysfunction and the progression of Parkinson's disease (PD). However, clinical this remains lacking.In study, index for diffusion tensor image analysis along perivascular space (ALPS index) was calculated to evaluate function.Overall, 289 patients with PD were enrolled in cross-sectional study. The ALPS found be negatively correlated age, severity, dyskinesia. In longitudinal information on a total 95 5-year follow-up examinations collected from Progression Marker Initiative, 33 which classified into low group, all others mid-high group based first tertile baseline index. results regression indicated significant main effect autonomic dysfunction, as well activities daily living. addition, had faster deterioration MDS-UPDRS part III II, Symbol Digit Modalities Test Hopkins Verbal Learning Test. Path showed acted mediator tTau/ Aβ1-42 cognitive change score at year 4 5.The index, neuroimaging marker function, motor symptoms, predictive symptoms function. Additionally, function may mediate role toxic protein decline. ANN NEUROL 2023;94:672-683.

Language: Английский

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Choroid plexus enlargement in mild cognitive impairment on MRI: a large cohort study

European Radiology, Journal Year: 2024, Volume and Issue: 34(8), P. 5297 - 5304

Published: Jan. 15, 2024

Language: Английский

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Enlarged choroid plexus in relapsing-remitting multiple sclerosis may lead to brain structural changes through the glymphatic impairment

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 85, P. 105550 - 105550

Published: March 11, 2024

Language: Английский

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Association between choroid plexus volume and cognition in Parkinson disease

European Journal of Neurology, Journal Year: 2023, Volume and Issue: 30(10), P. 3114 - 3123

Published: July 27, 2023

Abstract Background and purpose The choroid plexus (CP) clears harmful metabolites from the central nervous system as part of glymphatic system. We investigated association CP volume (CPV) with baseline longitudinal cognitive decline in patients Parkinson disease (PD). Methods retrospectively reviewed medical records 240 newly diagnosed PD who had undergone detailed neuropsychological tests high‐resolution T1‐weighted structural magnetic resonance imaging during initial assessment. CPV each patient was automatically segmented, intracranial ratio used subsequent analyses. relationship between composite scores domain assessed using multivariate linear regression A Cox proportional hazards model to compare risk dementia conversion CPV. Results negatively correlated frontal/executive function (β = −0.375, p 0.002) after adjusting for age, sex, years education, parkinsonian symptom duration. revealed that a larger associated higher (hazard [HR] 1.509, 0.038), which no longer significant domain. mediation analysis demonstrated effect on completely mediated by (direct effect: HR 1.203, 0.396; indirect 1.400, 0.015). Conclusions Baseline is function, subsequently influences PD.

Language: Английский

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Choroid plexus volume is increased in mood disorders and associates with circulating inflammatory cytokines

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 116, P. 52 - 61

Published: Nov. 27, 2023

Language: Английский

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In vivo imaging markers of glymphatic dysfunction in amyotrophic lateral sclerosis: Analysis of ALPS index and choroid plexus volume

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: 469, P. 123393 - 123393

Published: Jan. 11, 2025

Language: Английский

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MR Imaging Indices for Brain Interstitial Fluid Dynamics and the Effects of Orexin Antagonists on Sleep

Magnetic Resonance in Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The purpose of this study was to assess the extent which improvement in sleep with lemborexant contributed changes interstitial fluid dynamics. 3 methods including diffusion tensor image analysis along perivascular space (DTI-ALPS), dynamic contrast-enhanced method tissue vascular permeability (Ktrans), and choroid plexus volume (CPV) were used. Correlations between these imaging indices parameters (latency persistent [LPS], wake after onset [WASO], total time [TST], efficiency [SE]) evaluated using Pearson correlation analysis. Additionally, multiple regression linear mixed model employed relationship baseline status parameter changes. MRI assessments performed before treatment initiation (week 0, w0) at 12 weeks administration 12, w12). ALPS-index inversely correlated LPS positively TST SE w0. In analysis, lower when other than poor A suggested that w0 may have an effect on greater ALPS-index. evaluation Ktrans measurement, single showed a statistically significant reduction shortening LPS. Examination CPV negative w12. Multiple also w12 had Our results is related change be part improvement.

Language: Английский

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White matter injuries mediate brain age effects on cognitive function in cerebral small vessel disease

Neuroradiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

This study aims to investigate the potential effect of compromised structural integrity on cerebral aging and cognitive function in small vessel disease (CSVD). Fifty-five CSVD patients 42 controls underwent three-dimensional T1-weighted imaging diffusion tensor imaging. Relative brain age (RBA) was computed assess aging. Variables included cortical thickness, volume, white matter hyperintensity (WMH) peak width skeletonized mean diffusivity (PSMD), ventricular choroid plexus volume. Mini-Mental State Examination (MMSE) conducted general cognition. Trail Making Test (TMT) Auditory Verbal Learning were administered evaluate executive episodic memory, respectively. Mediation analysis multivariate linear regression with interaction terms performed explore differential impacts RBA between controls. significantly increased compared (p < 0.001). White injuries as assessed PSMD (mediation magnitude: 41.1%) WMH volume 56.9%) mediated relationship pathologies Higher correlated poorer scores MMSE, TMT-A, TMT-B 0.01). Additionally, 57.8% 48.3% 28.8% TMT-B) 55.1% MMSE) 0.05). play a critical role decline patients.

Language: Английский

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