Retinal Vascular Morphology Reflects and Predicts Cerebral Small Vessel Disease: Evidences from Eye-Brain Imaging Analysis

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Cerebral small vessel disease (SVD) involves ischemic white matter damage and choroid plexus (CP) dysfunction for cerebrospinal fluid (CSF) production. Given the vascular CSF links between eye brain, this study explored whether retinal morphology can indicate cerebrovascular injury CP in SVD. We assessed SVD burden using imaging phenotypes like hyperintensities (WMH), perivascular spaces, lacunes, microbleeds. Cerebrovascular was quantified by WMH volume peak width of skeletonized mean diffusivity (PSMD), while measured its dysfunction. Retinal markers were derived from fundus images, with associations analyzed generalized linear models Pearson correlations. Path analysis contributions to changes. Support vector machine developed predict severity demographic data. Among 815 participants, 578 underwent ocular imaging. Increased markedly correlated both cerebral biomarkers, alterations equally influenced enlargement. Machine learning showed robust predictive power severe (AUC 0.82), PSMD (0.81), (0.77), (0.80). These findings suggest that could serve as a cost-effective, noninvasive tool screening based on connections.

Language: Английский

---

Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 3, 2025

Abstract Background The choroid plexus (ChP) plays an important role in producing cerebrospinal fluid (CSF) and physical dysfunction has been associated with alterations CSF circulation. However, no population-based studies have thus far examined the association of ChP function older people. Methods This cross-sectional study included 1217 participants (age ≥ 60 years; 57.35% women) MRI substudy Multimodal Interventions to delay Dementia disability rural China. volume was automatically segmented using three-dimensional T1-weighted sequences. Physical assessed Short Performance Battery (SPPB). Data were analyzed general linear regression mediation models. Results Controlling for demographic characteristics, cardiovascular risk factors, stroke, disproportionately enlarged subarachnoid-space hydrocephalus (DESH), total intracranial volume, per 1-ml increase β-coefficient -0.24 (95% confidence interval: -0.37 -0.11) SPPB summary score, being stronger females (-0.40; -0.60 -0.20) than males (-0.17; -0.33 -0.01) (p volume×sex interaction = 0.028). associations similar across three domains balance, chair stand, walking speed. In addition, increased ventricular white matter hyperintensity (WMH) volume. Mediation analysis suggested that lateral periventricular WMH significantly mediated proportion 54.22% 14.48%, respectively. Conclusion Larger is poorer adults, especially women. largely by volumes. Graphical

Language: Английский

---

The emerging role of the circadian rhythm in the blood-brain barrier dysfunction associated with cerebral small vessel disease

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

The relationship between circadian rhythm and cerebrovascular disease has recently emerged as a fascinating area of research. It been found that the could affect development exacerbation cerebral small vessel (CSVD). Dysfunction blood-brain barrier (BBB) is one key players in mechanisms CSVD. This thought to be regulated by oscillations clock genes, which control transporter function, regulating permeability BBB endothelial cells, tight junction proteins, pericytes. Understanding interaction genes components may contribute promising treatments for

Language: Английский

---

New Imaging Markers in Multiple Sclerosis and Related Disorders

Neuroimaging Clinics of North America, Journal Year: 2024, Volume and Issue: 34(3), P. 359 - 373

Published: April 23, 2024

Concepts of multiple sclerosis (MS) biology continue to evolve, with observations such as "progression independent disease activity" challenging traditional phenotypic categorization. Iron-sensitive, susceptibility-based imaging techniques are emerging highly translatable MR sequences that allow for visualization at least 2 clinically useful biomarkers: the central vein sign and paramagnetic rim lesion (PRL). Both biomarkers demonstrate high specificity in discrimination MS from other mimics can be seen 1.5 T 3 field strengths. Additionally, PRLs represent a subset chronic active lesions engaged "smoldering" compartmentalized inflammation behind an intact blood-brain barrier.

Language: Английский

---

Choroid plexus enlargement in patients with obstructive sleep apnea

Sleep Medicine, Journal Year: 2024, Volume and Issue: 121, P. 179 - 183

Published: July 10, 2024

Language: Английский

---