Functional near-infrared spectroscopy and vagus somatosensory evoked potentials add to the power of established parameters such as poor cognitive performance, dsyosmia and APOe genotype to predict cognitive decline over 8 years in the elderly DOI Creative Commons
Martin J. Herrmann,

Alexandra Wuttke,

Linda Breuninger

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Alzheimer’s dementia is the main cause of cognitive impairment in people over age 65, with disease starting presumably 10–15 years before onset clinical symptoms. It therefore important to recognize at an early stage and identify possible predictors. The existing methods, like different parameters ß-Amyloid Tau quantification cerebrospinal fluid (CSF) or living brain by measure PET, are invasive expensive. Therefore, present study investigates predictive value a battery clinical, neuropsychological, blood as well two neurophysiological methods (functional near-infrared spectroscopy [fNIRS] vagus somatosensory evoked potentials [VSEP]) which easy perform, less cost-efficient, for developing impairments elderly. In this longitudinal, prospective study, we enrolled 604 healthy participants between 70 77 age. were invited back after mean time interval 3 11 months, 7 8 their determined. Here show that development approximately can be predicted not only previously known risk factors such ApoE4 alleles, dysosmia, poor performance baseline but latency prolongation VSEP altered functional activation patterns measured NIRS also provide additional value. We suggest both parameters, NIRS, should included future studies, investigating prediction dementia. Dementia ClinicalTrials.gov Identifier: NCT02224326.

Language: Английский

Differences in the cerebral amyloid angiopathy proteome in Alzheimer’s disease and mild cognitive impairment DOI Creative Commons
Dominique Leitner, Tomas Kavanagh, Evgeny Kanshin

et al.

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 148(1)

Published: July 22, 2024

Abstract Cerebral amyloid angiopathy (CAA) is characterized by beta (Aβ) deposition in cerebrovasculature. It prevalent with aging and Alzheimer’s disease (AD), associated intracerebral hemorrhage, contributes to cognitive deficits. To better understand molecular mechanisms, CAA(+) CAA(−) vessels were microdissected from paraffin-embedded autopsy temporal cortex of age-matched Control ( n = 10), mild impairment (MCI; 4), sporadic AD 6) cases, followed label-free quantitative mass spectrometry. 257 proteins differentially abundant compared neighboring MCI, 289 p < 0.05, fold-change > 1.5). 84 changed the same direction both groups, many among significant at least one group 0.0001, R 2 0.62). In vessels, significantly increased MCI particularly collagen-containing extracellular matrix, while ribonucleoprotein complex decreased MCI. 61 112 when cases. Increased external encapsulating structure, matrix MCI; collagen trimer AD. Twenty two Comparison CAA proteome published amyloid-plaque proteomic datasets identified similarly enriched plaques, as well a protein subset hypothesized preferentially plaques. SEMA3G emerged specific marker, validated immunohistochemically correlation pathology levels 0.0001; 0.90). Overall, vessel proteomes indicated changes integrity absence Aβ, was similar AD, which vascular reorganization, translation deficits, blood brain barrier breakdown.

Language: Английский

Citations

6
Association of small vessel disease progression with longitudinal cognitive decline across mild cognitive impairment DOI Creative Commons
Jingru Wang,

Asta Debora,

Lixuan Chen

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Background Cerebral small vessel disease (SVD) is the leading cause of vascular dementia. However, it unclear whether individual SVD or global progression correlates with cognitive decline across mild impairment (MCI) subjects. Objective To investigate association longitudinal MCI. Methods We included 432 participants from Alzheimer's Disease Neuroimaging Initiative (ADNI) database, 151 in cognitively normal (CN) group and 281 MCI group. evaluated magnetic resonance imaging–based markers both CN groups explored their associations 12-and 24-month using linear mixing effect (LME) models. Results In group, cerebral microbleed (CMB) was associated language function (p < 0.05), deep white matter hyperintensity (WMH) a memory 0.05). CMB 0.05) lacunes executive whereas score not related to function. Conclusions The WMH had an impact on groups, only Our study suggested that may have higher predictive value cognition compared burden.

Language: Английский

Citations

0
Exploring the Potential of Precision Medicine in Neuropsychiatry: A Commentary on New Insights for Tailored Treatments Based on Genetic, Environmental, and Lifestyle Factors DOI Open Access
Jelena Milić, Milica Vučurović, Dragana Jović

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 371 - 371

Published: March 24, 2025

Neuropsychiatric disorders are complex conditions with multifactorial etiologies, in which genetics play a pivotal role. Despite significant advancements psychiatric research, traditional treatment options remain largely symptomatic, focusing on clinical signs without fully addressing the underlying biological causes. However, recent developments precision medicine—an approach that tailors treatments based genetic, environmental, and lifestyle factors—hold great promise for transforming of these disorders. By identifying specific genetic markers understanding gene–environment interactions, medicine can offer more personalized effective treatments, leading to better patient outcomes. Our primary aim was explore how integrating data environmental factors could enhance neuropsychiatric such as schizophrenia, bipolar disorder, depression. The secondary examine potential pharmacogenomics gene therapy improving therapeutic strategies. results indicate while progress has been made, challenges remain, including complexity interactions need granular phenotypic data. In conclusion, revolutionize by providing individualized care considers makeup, influences, factors, paving way therapies improved

Language: Английский

Citations

0
Multiple Chronic Conditions and Polypharmacy in Cognitively Unimpaired Older Adults are Associated with Subsequent Cognitive Decline: Results from the National Alzheimer's Coordinating Center Data DOI
Chooza Moon,

Meina Zhang,

Boxiang Wang

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 134, P. 105846 - 105846

Published: April 6, 2025

Language: Английский

Citations

0
Navigating Alzheimer’s Disease Mouse Models: Age-Related Pathology and Cognitive Deficits DOI Creative Commons
Laura M. De Plano,

Alessandra Saitta,

Salvatore Oddo

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1405 - 1405

Published: Nov. 5, 2024

Since the mid-1990s, scientists have been generating mouse models of Alzheimer's disease to elucidate key mechanisms underlying onset and progression aid in developing potential therapeutic approaches. The first successful model was reported 1995 with generation PDAPP mice, which were obtained by overexpression gene coding for amyloid precursor protein (APP). then, used different approaches develop other APP mice overexpressing tau, or a combination them. More recently, Saito colleagues generated knocking mutations associated familial into gene. In this review, we will describe most animal provide practical guide disease's age progression. We believe that be valuable planning experimental design studies utilizing these models.

Language: Английский

Citations

3
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience DOI Creative Commons
Keenan A. Walker,

Yang An,

Abhay Moghekar

et al.

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: Oct. 31, 2024

Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine biological mechanisms that allow some APOEε4 carriers maintain normal cognitive functioning in older adulthood.

Language: Английский

Citations

2
Dementia. Specifics of its manifestations. Clinical patterns of dementia in Alzheimer's disease DOI Creative Commons

R.К. Shiralieva

Cifra. Клиническая медицина., Journal Year: 2024, Volume and Issue: 2

Published: Oct. 23, 2024

Современная медицина часто сталкивается с различными видами деменции, связанными болезнью Альцгеймера, лобно-височными расстройствами и образованием телец Леви в головном мозге, а также развивающимися на фоне болезни Паркинсона.В данной статье рассмотрены особенности заболевания, вызывающие нарушение поведения, эмоций взаимоотношений, влияющее снижение мышления способностей больного. В представлен обзорный анализ научных статей, статистических показателей, связанных клиническими, лабораторными, инструментально-диагностическими проявлениями деменции. Исследование носит описательный характер основано результатах ранее опубликованных работ. Представленные данные основном сосредоточены особенностях проявлений деменции при различных заболеваниях, ее причин возникновения, видов, стадий применяемых мер для лечения. Была использована литература как зарубежная, так национальном языке.В результате было выявлено, что исследователи добились значительного прогресса разработке, тестировании проверке многих аспектов этого том числе касающихся биологических маркеров, которые обнаруживают признаки патологического процесса.В итоге выяснилось, все виды, не исключая деменцию скорее всего, потребуют комплексного лечения, индивидуально подобранного каждого человека, старение остается наиболее важным фактором риска его развития.

Language: Русский

Citations

0
Functional near-infrared spectroscopy and vagus somatosensory evoked potentials add to the power of established parameters such as poor cognitive performance, dsyosmia and APOe genotype to predict cognitive decline over 8 years in the elderly DOI Creative Commons
Martin J. Herrmann,

Alexandra Wuttke,

Linda Breuninger

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Alzheimer’s dementia is the main cause of cognitive impairment in people over age 65, with disease starting presumably 10–15 years before onset clinical symptoms. It therefore important to recognize at an early stage and identify possible predictors. The existing methods, like different parameters ß-Amyloid Tau quantification cerebrospinal fluid (CSF) or living brain by measure PET, are invasive expensive. Therefore, present study investigates predictive value a battery clinical, neuropsychological, blood as well two neurophysiological methods (functional near-infrared spectroscopy [fNIRS] vagus somatosensory evoked potentials [VSEP]) which easy perform, less cost-efficient, for developing impairments elderly. In this longitudinal, prospective study, we enrolled 604 healthy participants between 70 77 age. were invited back after mean time interval 3 11 months, 7 8 their determined. Here show that development approximately can be predicted not only previously known risk factors such ApoE4 alleles, dysosmia, poor performance baseline but latency prolongation VSEP altered functional activation patterns measured NIRS also provide additional value. We suggest both parameters, NIRS, should included future studies, investigating prediction dementia. Dementia ClinicalTrials.gov Identifier: NCT02224326.

Language: Английский

Citations

0